Bioactive Compounds of Citrus Fruits: A Review of Composition and Health Benefits of Carotenoids, Flavonoids, Limonoids, and Terpenes

Antioxidants, Journal Year: 2022, Volume and Issue: 11(2), P. 239 - 239

Published: Jan. 26, 2022

The increased consumption of fruits, vegetables, and whole grains contributes to the reduced risk many diseases related metabolic syndrome, including neurodegenerative diseases, cardiovascular disease (CVD), diabetes, cancer. Citrus, genus Citrus L., is one most important fruit crops, rich in carotenoids, flavonoids, terpenes, limonoids, other bioactive compounds nutritional nutraceutical value. Moreover, polymethoxylated flavones (PMFs), a unique class abundantly occur citrus fruits. In addition, essential oil, limonoids an economically product due its potent antioxidant, antimicrobial, flavoring properties. Mechanistic, observational, intervention studies have demonstrated health benefits bioactives minimizing syndrome. This review provides comprehensive view composition fruits their associated benefits.

Language: Английский

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Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids

Pharmaceutics, Journal Year: 2021, Volume and Issue: 13(5), P. 660 - 660

Published: May 5, 2021

Flavonoids are among the most abundant natural bioactive compounds produced by plants. Many different activities have been reported for these secondary metabolites against numerous cells and systems. One of interesting is certainly antimicrobial, which stimulated through various molecular mechanisms. In fact, flavonoids effective both in directly damaging envelope Gram-negative Gram-positive bacteria but also acting toward specific targets essential survival microorganisms. The purpose this paper to present an overview results obtained research focused on study interactions between bacterial proteins. Despite great structural heterogeneity plant metabolites, it observe that many affect same cellular pathways. Furthermore, evident some interact with more than one target, producing multiple effects. Taken together, data demonstrate potential developing innovative systems, can help address increasingly serious problem antibiotic resistance.

Language: Английский

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Bioaccessibility and bioavailability of phytochemicals: Influencing factors, improvements, and evaluations

Food Hydrocolloids, Journal Year: 2022, Volume and Issue: 135, P. 108165 - 108165

Published: Sept. 23, 2022

Language: Английский

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Unique roles in health promotion of dietary flavonoids through gut microbiota regulation: Current understanding and future perspectives

Food Chemistry, Journal Year: 2022, Volume and Issue: 399, P. 133959 - 133959

Published: Aug. 18, 2022

Language: Английский

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Improving the stability and bioavailability of tea polyphenols by encapsulations: a review

Food Science and Human Wellness, Journal Year: 2022, Volume and Issue: 11(3), P. 537 - 556

Published: Feb. 4, 2022

Tea polyphenols (TPPs) have attracted significant research interest due to their health benefits. However, TPPs are sensitive certain environmental and gastrointestinal conditions oral bioavailability was found be very low. Delivery systems made of food-grade materials been reported improve the shelf-life, bioefficacy TPPs. This review discusses chemistry TPPs; setbacks for application; strategies counteract application limitations by rationally designing delivery systems. An overview different formulations used encapsulate is provided in this study, such as emulsion-based (liposome, nanoemulsion, double emulsion, Pickering emulsion) nano/microparticles-based (protein-based, carbohydrate-based, bi-polymer based). In addition, stability, bioactivities encapsulated evaluated various vitro vivo models. The current findings provide scientific insights encapsulation approaches TPPs, which can great value TPPs-fortified food products. Further explorations needed terms applications real industry well biological fate functional pathways vivo.

Language: Английский

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Modulation of redox-sensitive transcription factors with polyphenols as pathogenetically grounded approach in therapy of systemic inflammatory response

Heliyon, Journal Year: 2023, Volume and Issue: 9(5), P. e15551 - e15551

Published: April 16, 2023

One of the adverse outcomes acute inflammatory response is progressing to chronic stage or transforming into an aggressive process, which can develop rapidly and result in multiple organ dysfunction syndrome. The leading role this process played by Systemic Inflammatory Response that accompanied production pro- anti-inflammatory cytokines, phase proteins, reactive oxygen nitrogen species.The purpose review highlights both recent reports results authors' own research encourage scientists new approaches differentiated therapy various SIR manifestations (low- high-grade systemic phenotypes) modulating redox-sensitive transcription factors with polyphenols evaluate saturation pharmaceutical market appropriate dosage forms tailored for targeted delivery these compounds.Redox-sensitive such as NFκB, STAT3, AP1 Nrf2 have a mechanisms formation low- phenotypes variants SIR. These phenotypic underlie pathogenesis most dangerous diseases internal organs, endocrine nervous systems, surgical pathologies, post-traumatic disorders.The use individual chemical compounds class polyphenols, their combinations be effective technology Administering natural oral very beneficial management number low-grade phenotype. associated phenotype requires medicinal phenol preparations manufactured parenteral administration.

Language: Английский

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Effects of several flavonoids on human gut microbiota and its metabolism by in vitro simulated fermentation

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 2, 2023

Flavonoids have antiviral, antitumor, anti-inflammatory, and other biological activities. They high market value are widely used in food medicine fields. also can regulate gut microbiota promote human health. However, only a few flavonoids been reported for their regulatory effects on microbiota. The of hesperidin, hesperetin-7-O-glucoside, hesperetin, naringin, prunin, naringenin, rutin, isoquercitrin, quercetin structural metabolic differences healthy subjects were studied by means vitro simulated fermentation technology. Results showed that the nine kinds mentioned above, especially found to more effect structure microbiota, they could significantly enhance Bifidobacterium (p < 0.05). After 24 h fermentation, relative abundance intestinal probiotics (e.g., Lactobacillus) was increased three rutin. Furthermore, potential pathogenic bacteria decreased addition isoquercitrin Lachnoclostridium Bilophila). Notably, prunin markedly decrease content H2S, NH3, short-chain fatty acids. This performance fully demonstrated its broad-spectrum antibacterial activity. study demonstrates imbalance some observed due different structures. work provides theoretical basis wide application medicine.

Language: Английский

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The Potential of Flavonoids and Flavonoid Metabolites in the Treatment of Neurodegenerative Pathology in Disorders of Cognitive Decline

Antioxidants, Journal Year: 2023, Volume and Issue: 12(3), P. 663 - 663

Published: March 7, 2023

Flavonoids are a biodiverse family of dietary compounds that have antioxidant, anti-inflammatory, antiviral, and antibacterial cell protective profiles. They received considerable attention as potential therapeutic agents in biomedicine been widely used traditional complimentary medicine for generations. Such medical herbal formulations extremely complex mixtures many pharmacologically active provide outcome through network pharmacological effects complexity. Methods emerging to determine the components their targets decipher complexities how pharmacology provides such effects. The gut microbiome has important roles play generation bioactive flavonoid metabolites retaining or exceeding antioxidative anti-inflammatory properties intact and, some cases, new antitumor antineurodegenerative bioactivities. Certain food items identified with high prebiotic profiles suggesting neutraceutical supplementation may be beneficially employed preserve healthy population bacterial symbiont species minimize establishment harmful pathogenic organisms. Gut health is an consideration effecting overall wellbeing linked organ systems. Bioconversion generates can also transported by vagus nerve systemic circulation brain populations exert beneficial effect. This particularly number neurological disorders (autism, bipolar disorder, AD, PD) characterized on moods, resulting depression anxiety, impaired motor function, long-term cognitive decline. Native flavonoids alleviation inflammation tissues, however, concerns raised levels not achieved, thus allowing them display optimal Dietary manipulation vagal stimulation both yielded responses treatment autism spectrum disorders, depression, establishing route communication gut-brain axis established disease intervention. While native known penetrate blood–brain barrier, microbiome-generated (e.g., protocatechuic acid, urolithins, γ-valerolactones), which retain antioxidant potency addition promote mitochondrial cerebrovascular microcapillary should considered biotherapeutic agents. Studies warranted experimentally examine efficacy directly, they emerge novel options.

Language: Английский

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Main drivers of (poly)phenol effects on human health: metabolite production and/or gut microbiota-associated metabotypes?

Food & Function, Journal Year: 2021, Volume and Issue: 12(21), P. 10324 - 10355

Published: Jan. 1, 2021

The final drivers for the health effects of (poly)phenol consumption have not been fully identified. Specific associations between and circulating-excreted metabolites and(or) gut microbial ecologies do prove a causal role.

Language: Английский

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Therapeutic Effects of Citrus Flavonoids Neohesperidin, Hesperidin and Its Aglycone, Hesperetin on Bone Health

Biomolecules, Journal Year: 2022, Volume and Issue: 12(5), P. 626 - 626

Published: April 23, 2022

Flavonoids are natural phytochemicals that have therapeutic effects and act in the prevention of several pathologies. These can be found seeds, grains, tea, coffee, wine, chocolate, cocoa, vegetables and, mainly, citrus fruits. Neohesperidin, hesperidin hesperetin flavonoids from flavanones subclass anti-inflammatory antioxidant potential. form neohesperidin dihydrochalcone (NHDC), also has dietary properties as a sweetener. In general, these been investigated strategy to control bone diseases, such osteoporosis osteoarthritis. this literature review, we compiled studies neohesperidin, its aglycone, hesperetin, on health. vitro showed exerted an antiosteoclastic anti- inflammatory effects, inhibiting expression osteoclastic markers reducing levels reactive oxygen species, proinflammatory cytokines matrix metalloproteinase levels. Similarly, favored osteogenic potential preosteoblastic cells induced overexpression markers. vivo, regeneration defects minimized inflammation arthritis- periodontitis-induced models. Additionally, they significant anticatabolic effect ovariectomy models, trabecular loss increasing mineral density. Although research should advance clinical field, may for controlling progression metabolic, autoimmune or diseases.

Language: Английский

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