Asian Journal of Organic Chemistry,
Journal Year:
2021,
Volume and Issue:
10(11), P. 2820 - 2847
Published: Aug. 30, 2021
Abstract
Electro‐organic
reactions
are
now
considered
as
one
of
the
most
efficient
and
environmentally
benign
methodologies
to
synthesize
highly
functionalized
motifs
like
difunctionalized
unsaturated
compounds
from
readily
available
substrates.
Excellent
regioselectivity,
functional
group
tolerance
broad
range
substrates
main
advantages
electrochemical
difunctionalization
reactions.
Alkenes
alkynes
accept
radical
or
ionic
derivatives
which
makes
it
vital
precursors
for
synthesis
industrially
relevant
biologically
active
molecules
through
difunctionalization.
This
review
aims
provide
readers
an
excellent
coverage
different
alkenes
such
1,2‐homodifunctionalization,
1,2‐heterodifunctionalization,
rearrangement,
ipso
‐migration,
cyclization
dehydrogenative
annulation
ACS Sustainable Chemistry & Engineering,
Journal Year:
2021,
Volume and Issue:
9(18), P. 6148 - 6169
Published: April 27, 2021
Paired
electrolysis
is
highly
valuable
from
the
viewpoint
of
efficiency
as
well
atom
and
energy
economies.
In
order
to
optimize
latter
two
for
chemical
reactions,
development
paired
electrochemical
processes
necessary.
When
both
electrodes
in
an
cell
(divided
undivided)
are
applied
working
electrodes,
sides
(oxidation
reduction)
yield
compounds,
this
ideal
phenomena
defined
electrosynthesis.
This
offers
opportunity
reduce
spent
time,
when
compared
with
a
single
system
that
only
used
achieve
product
interest,
while
ignoring
other
side
(anodic
or
cathodic).
case,
200%
current
could
be
achieved
during
electrosynthesis
using
cathodic
anodic
provide
same
product.
efficient
green
process
and,
therefore,
beneficial
preserving
resources
minimizing
waste.
However,
beneficial,
oxidation
reduction
must
compatible
counter
losses
equally
ease
separation
purification
electrode
products.
Greater
efforts
required
perform
more
systematic
rational
approach
optimal
products
under
conditions.
Nevertheless,
new
computational
tools
assistance
matter.
There
considerable
level
adventure
designing
electrosynthetic
accompanying
opportunities
design
innovative
powerful
synthetic
strategies.
Herein,
overview
several
examples
electrosyntheses
their
advantages
summarized
will
aid
researchers
develop
greater
understanding
subject
subsequently
employ
sustainable
synthesis
organic
molecules.
Chemical Science,
Journal Year:
2021,
Volume and Issue:
12(29), P. 10092 - 10096
Published: Jan. 1, 2021
Radical
spirocyclization
via
dearomatization
has
emerged
as
an
attractive
strategy
for
the
rapid
synthesis
of
structurally
diverse
spiro
molecules.
We
report
use
electrochemistry
to
perform
oxidative
biaryls
leading
tri-
and
difluoromethylated
spiro[5.5]trienones
in
a
user
friendly
undivided
cell
set-up
constant
current
mode.
The
catalyst-
chemical
oxidant-free
procedure
features
ample
scope,
employs
electricity
green
sole
oxidant.
Organic Chemistry Frontiers,
Journal Year:
2021,
Volume and Issue:
8(11), P. 2710 - 2771
Published: Jan. 1, 2021
This
review
presents
a
critical
and
authoritative
analysis
of
several
exciting
benzannulation
approaches
developed
in
the
past
decade
for
construction
carbazoles,
indolocarbazoles,
benzocarbazoles,
carbolines.
The Chemical Record,
Journal Year:
2021,
Volume and Issue:
21(9), P. 2585 - 2600
Published: April 8, 2021
Progress
in
electroorganic
synthesis
is
linked
to
innovation
of
new
synthetic
reactions
with
impact
on
medicinal
chemistry
and
drug
discovery
the
desire
minimise
waste
provide
energy-efficient
chemical
transformations
for
future
industrial
processes.
Paired
electrosynthetic
processes
that
combine
use
both
anode
cathode
(convergent
or
divergent)
minimal
(or
without)
intentionally
added
electrolyte
need
additional
reagents
are
growing
interest.
In
this
overview,
recent
progress
developing
paired
electrolytic
surveyed.
The
discussion
focuses
electrosynthesis
technology
proven
value
preparation
small
molecules.
Reactor
types
contrasted
concept
translating
light-energy
driven
photoredox
into
highlighted
as
a
newly
emerging
trend.
Green Chemistry,
Journal Year:
2022,
Volume and Issue:
24(13), P. 5058 - 5063
Published: Jan. 1, 2022
The
electrochemical
annulation
of
enaminones/analogous
enamines
and
thioureas
providing
2-aminothiazoles
has
been
realized.
Modulating
the
electrolyte
enables
diastereoselective
synthesis
4,5-dialkoxyl
thiazolines
by
dearomatization.
Chemistry - An Asian Journal,
Journal Year:
2023,
Volume and Issue:
18(9)
Published: March 15, 2023
Electrochemical
dearomative
spirocyclization
serves
as
a
green
and
sustainable
approach
to
convert
the
flat,
two-dimension
aromatic
feedstock
into
value-added
three-dimension
spirocyclic
architectures.
This
review
highlights
recent
advances,
emphasizes
mechanistic
discussions,
showcases
synthetic
applications
of
this
emerging
versatile
powerful
transformation.
Asian Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
12(8)
Published: July 20, 2023
Abstract
In
terms
of
pharmaceuticals
and
biological
applications,
synthesis
complex
organic
molecules
is
a
significant
fast‐developing
area.
this
context,
electrosynthesis
an
alternative
way
to
the
traditional
methods
for
chemo‐,
regio‐,
stereoselective
syntheses.
Electro‐organic
reactions
occur
at
room
temperature
normal
pressure,
through
transferring
electrons.
It
has
been
found
that
mild
approach
preparing
electrophilic
substrates,
bases,
nucleophiles
in
situ
,
from
highly
stable
low‐level
reagents;
which
can
be
further
applied
make
heterocycles
more
accessible.
While
several
promising
exist,
multi‐component
(MCRs)
have
drawn
much
attention
both
academia
industry
worldwide,
since
they
are
cost‐efficient
environmentally
friendly.
Combining
MCRs
produced
great
strategy
field
research.
This
review
focuses
on
recent
advances
electrochemical
heterocyclic
compounds
via
reactions,
reported
between
2015
March
2023.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(24), P. 3226 - 3239
Published: Jan. 1, 2024
This
feature
article
presents
an
overview
of
continuous
flow
chemistry,
including
photoflow
and
electroflow
technologies
in
the
preparation
active
pharmaceutical
ingredients
(APIs)
fine
chemical
intermediates.
