Fortschritte der Chemie Organischer Naturstoffe/Fortschritte der Chemie organischer Naturstoffe/Progress in the chemistry of organic natural products,
Journal Year:
2022,
Volume and Issue:
unknown, P. 101 - 130
Bioorganic Chemistry,
Journal Year:
2023,
Volume and Issue:
138, P. 106600 - 106600
Published: May 11, 2023
Guanidines
are
fascinating
small
nitrogen-rich
organic
compounds,
which
have
been
frequently
associated
with
a
wide
range
of
biological
activities.
This
is
mainly
due
to
their
interesting
chemical
features.
For
these
reasons,
for
the
past
decades,
researchers
synthesizing
and
evaluating
guanidine
derivatives.
In
fact,
there
currently
on
market
several
guanidine-bearing
drugs.
Given
broad
panoply
pharmacological
activities
displayed
by
in
this
review,
we
chose
focus
antitumor,
antibacterial,
antiviral,
antifungal,
antiprotozoal
presented
natural
synthetic
derivatives,
undergoing
preclinical
clinical
studies
from
January
2010
2023.
Moreover,
also
present
guanidine-containing
drugs
treatment
cancer
infectious
diseases.
setting,
most
synthesized
derivatives
being
evaluated
as
antitumor
antibacterial
agents.
Even
though
DNA
known
target
type
cytotoxicity
involves
other
different
mechanisms,
such
interference
bacterial
cell
membranes,
reactive
oxygen
species
(ROS)
formation,
mitochondrial-mediated
apoptosis,
mediated-Rac1
inhibition,
among
others.
As
compounds
already
used
drugs,
main
application
types
cancer,
breast,
lung,
prostate,
leukemia.
Guanidine-containing
bacterial,
antiprotozoal,
antiviral
infections
and,
recently,
proposed
COVID-19.
To
conclude,
group
privileged
scaffold
drug
design.
Its
remarkable
cytotoxic
activities,
especially
field
oncology,
still
make
it
suitable
deeper
investigation
afford
more
efficient
target-specific
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 11, 2025
A
one-pot
synthesis
of
a
tricyclic
guanidine
scaffold
is
developed.
The
azido-bearing
[3
+
2]
adducts
are
used
for
cascade
azide-isocyanide
cross-coupling/nucleophilic
cyclization/lactamization
to
afford
highly
condensed
polyheterocycles.
wide
range
azido-containing
and
isocyanides
tolerated
in
the
sequential
reactions.
Natural Product Reports,
Journal Year:
2021,
Volume and Issue:
39(3), P. 596 - 669
Published: Oct. 14, 2021
The
isolation
of
water-soluble
metabolites
significantly
diminished
during
the
last
decades.
A
comprehensive
analysis
on
hydrophilic
natural
products
is
discussed
with
a
perspective
for
future
product
sciences.
Molecules,
Journal Year:
2022,
Volume and Issue:
27(3), P. 734 - 734
Published: Jan. 23, 2022
Kirenol,
a
potential
natural
diterpenoid
molecule,
is
mainly
found
in
Sigesbeckia
species.
Kirenol
has
received
lot
of
interest
recent
years
due
to
its
wide
range
pharmacological
actions.
In
particular,
it
significant
ability
interact
with
molecular
targets
associated
inflammation.
this
review,
we
summarise
the
efficacy
and
safety
kirenol
reducing
inflammation,
as
well
mechanisms
action
opportunities
future
drug
development.
Based
on
preclinical
studies
reported
earlier,
good
therapeutic
against
inflammation
involved
multiple
sclerosis,
inflammatory
bowel
disorders,
diabetic
wounds,
arthritis,
cardiovascular
disease,
bone
damage,
joint
disorders.
We
also
address
physicochemical
drug-like
features
kirenol,
structurally
modified
kirenol-derived
molecules.
The
inhibition
pro-inflammatory
cytokines,
reduction
nuclear
factor
kappa-B
(NF-κB),
attenuation
antioxidant
enzymes,
stimulation
heme-oxygenase-1
(HO-1)
expression,
erythroid
2-related
2
(Nrf2)
phosphorylation
are
among
contributing
kirenol's
anti-inflammatory
Furthermore,
review
highlights
challenges
improve
delivery
for
treating
According
findings
an
active
molecule
numerous
models,
indicating
path
using
new
discovery
development
treatment
inflammations.
The Chemical Record,
Journal Year:
2023,
Volume and Issue:
23(7)
Published: March 22, 2023
Abstract
This
account
describes
our
recent
work
on
developing
guanidinium
hypoiodite‐
catalysts
for
oxidative
carbon‐nitrogen
and
carbon‐carbon
bond‐forming
reactions.
These
reactions
proceeded
smoothly
using
hypoiodite
generated
in
situ
by
treating
1,3,4,6,7‐hexahydro‐2H‐pyrimido[1,2‐a]pyrimidine
hydroiodide
salts
with
an
oxidant.
In
this
approach,
the
ionic
interaction
hydrogen
bonding
ability
of
cations
enable
that
have
been
difficult
conventional
methods.
Enantioselective
reaction
was
also
achieved
a
chiral
organocatalyst.
