Nanomaterial-based contrast agents

Nature Reviews Methods Primers, Journal Year: 2023, Volume and Issue: 3(1)

Published: April 13, 2023

Language: Английский

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Oxidative stress modulating nanomaterials and their biochemical roles in nanomedicine

Nanoscale Horizons, Journal Year: 2024, Volume and Issue: 9(10), P. 1630 - 1682

Published: Jan. 1, 2024

Many pathological conditions are predominantly associated with oxidative stress, arising from reactive oxygen species (ROS); therefore, the modulation of redox activities has been a key strategy to restore normal tissue functions. Current approaches involve establishing favorable cellular environment through administration therapeutic drugs and redox-active nanomaterials (RANs). In particular, RANs not only provide stable reliable means delivery but also possess capacity finely tune various interconnected components, including radicals, enzymes, proteins, transcription factors, metabolites. Here, we discuss roles that engineered play in spectrum conditions, such as cancer, neurodegenerative diseases, infections, inflammation. We visualize dual functions both generator scavenger ROS, emphasizing their profound impact on diverse The focus this review is solely inorganic (inorganic RANs). Additionally, deliberate challenges current RANs-based propose potential research directions for future clinical translation.

Language: Английский

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Boosting room-temperature NO2 detection via in-situ interfacial engineering on Ag2S/SnS2 heterostructures

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 434, P. 128782 - 128782

Published: March 26, 2022

Language: Английский

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CT and X-ray contrast agents: Current clinical challenges and the future of contrast

Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 171, P. 19 - 36

Published: Sept. 20, 2023

Language: Английский

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Mesoporous materials 2.0: innovations in metals and chalcogenides for future applications

Bulletin of the Chemical Society of Japan, Journal Year: 2025, Volume and Issue: 98(1)

Published: Jan. 1, 2025

Abstract Incorporating mesoporous structures into various materials can provide abundant active sites and facilitate smooth diffusion, their effectiveness has been demonstrated across a range of material types. However, despite the development numerous materials, first-generation (e.g., silica-based compositions) have limited applications due to poor electrical conductivity compositional diversity, necessitating additional processing for widespread utilization. Our group first proposed synthesis metals using solution-based soft-templating method based on self-assembly micelles, marking significant advancement in materials. This effective process recently extended chalcogenides. Chalcogenides garnered attention intriguing optical, electrical, electrochemical properties arising from distinctive electronic structures. Mesoporous chalcogenides found effectively enhance these properties. paper provides comprehensive review chalcogenides—representing second-generation (mesoporous 2.0)—with specific examples. goal is inform readers about insights further research.

Language: Английский

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Advances on chalcogenide quantum dots-based sensors for environmental pollutants monitoring

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 931, P. 172848 - 172848

Published: May 3, 2024

Water contamination represents a significant ecological impact with global consequences, contributing to water scarcity worldwide. The presence of several pollutants, including heavy metals, pharmaceuticals, pesticides, and pathogens, in resources underscores pressing concern, prompting the European Union (EU) establish Watch List monitor level these substances. Nowadays, standard methods used detect quantify contaminants are mainly liquid or gas chromatography coupled mass spectrometry (LC/GC–MS). While methodologies offer precision accuracy, they require expensive equipment experienced technicians, cannot be on field. In this context, chalcogenide quantum dots (QDs)-based sensors have emerged as promising, user-friendly, practical, portable tools for environmental monitoring. QDs semiconductor nanocrystals that possess excellent properties, demonstrated versatility across various sensor types, such fluorescent, electrochemical, plasmonic, colorimetric ones. This review summarizes recent advances (2019–2023) use sensing, highlighting development capable efficiently anions, endocrine disrupting compounds, organic dyes, toxic gases, nitroaromatics, pathogens.

Language: Английский

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Noninvasive Gastrointestinal Tract Imaging Using BSA-Ag₂Te Quantum Dots as a CT/NIR-II Fluorescence Dual-Modal Imaging Probe in Vivo

ACS Biomaterials Science & Engineering, Journal Year: 2022, Volume and Issue: 9(1), P. 449 - 457

Published: Dec. 8, 2022

The combination of high-resolution computed tomography (CT) and the real-time sensitive second near-infrared window (NIR-II) fluorescence bioimaging can provide complementary information for diagnosis, progression prognosis gastrointestinal disorders. Ag2Te quantum dots (QDs) are a kind promising CT/NIR-II dual-modal imaging probe due to their high atomic number narrow bandgap. However, conventional QDs synthesized by oil phase approaches often suffer from complicated steps, harsh reaction conditions, toxic organic solvents. Herein, we report synthesis bovine serum albumin (BSA)-Ag2Te using biomineralization approach tract. BSA-Ag2Te fabricated in facile one-pot under mild conditions exhibit homogeneous size, favorable monodispersity, admirable aqueous solubility, excellent X-ray attenuation properties, outstanding NIR-II performance. In vivo experiments show that be used tract with spatiotemporal resolution sensitivity. addition, an intestinal obstruction mouse model, accurate lesion positioning imaging-guided relief surgery successfully realized based on QDs. Besides, have biocompatibility vitro vivo. This study presents high-performance biosafe visualizing

Language: Английский

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Cannabidiol and its application in the treatment of oral diseases: therapeutic potentials, routes of administration and prospects

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 176, P. 116271 - 116271

Published: May 24, 2024

Cannabidiol (CBD), one of the most important active ingredients in cannabis, has been reported to have some pharmacological effects such as antibacterial and analgesic effects, therapeutic potential treatment oral diseases cancer, gingivitis periodontal diseases. However, there is a lack relevant systematic research reviews. Therefore, based on etiology clinical symptoms several common diseases, this paper focuses CBD pulp mucosal cancer temporomandibular joint The distribution function its receptors cavity are also summarized. In order provide reference for future further application CBD, we summarize possible routes administration corresponding characteristics. Finally, challenges faced while applying clinically solutions discussed, look future.

Language: Английский

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Synthesis and antibacterial effects of silver nanoparticles (AgNPs) against multi-drug resistant bacteria

Bio-Medical Materials and Engineering, Journal Year: 2024, Volume and Issue: 35(5), P. 451 - 463

Published: July 12, 2024

BACKGROUND: The emergence of the global problem multi-drug resistant bacteria (MDR) is closely related to improper use antibiotics, which gives birth an urgent need for antimicrobial innovation in medical and health field. Silver nanoparticles (AgNPs) show significant antibacterial potential because their unique physical chemical properties. By accurately regulating morphology, size surface properties AgNPs, AgNPs can be effectively enhanced become a next generation material with great development potential. OBJECTIVE: detection inhibitory effect on MDR provides more possibilities research new agents. METHODS: Promote formation by redox reaction; determine minimum concentration (MIC) broth microdilution method; evaluate killing efficacy against multi-drug-resistant plate counting; biofilm construction crystal violet staining; study drug resistance gradually increasing AgNPs; detect toxicity cells CCK-8 method. RESULTS: has bactericidal variety drug-resistant bacteria. After exposure solution 12 hours, number E. coli decreased sharply, S. aureus was basically eliminated after 16 hours. In particular, showed stronger inhibition Gram-negative addition, hinder bacterial biofilm, its increases increase concentration. When used long time, it slow. From point view safety, no harmful effects organisms biosafety. CONCLUSION: inhibit MDR, bacteriostatic ability higher than that Gram-positive It also avoid reduce cytotoxicity.

Language: Английский

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Silver Nanoparticles: A Versatile Tool Against Infectious and Non-Infectious Diseases

Antibiotics, Journal Year: 2025, Volume and Issue: 14(3), P. 289 - 289

Published: March 11, 2025

Silver nanoparticles possess remarkable properties that render them highly beneficial for medical applications in both infectious and non-infectious diseases. Among their most renowned attributes is antimicrobial activity. They have demonstrated efficacy against a wide range of bacteria, fungi, protozoa, viruses. Additionally, the antitumor anti-diabetic silver nanoparticles, along with ability to promote wound healing application as biosensors, underscore therapeutic potential various conditions. As are employed purposes, toxicity must be considered. While present promising alternative domain, further research needed elucidate precise mechanisms action, optimize efficacy, mitigate any health risks associated use.

Language: Английский

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