RSC Advances,
Journal Year:
2020,
Volume and Issue:
10(70), P. 42644 - 42681
Published: Jan. 1, 2020
Multicomponent
reactions
(MCRs)
are
powerful
synthetic
tools
in
which
more
than
two
starting
materials
couple
with
each
other
to
form
multi-functionalized
compounds
a
one-pot
process,
the
so-called
"tandem",
"domino"
or
"cascade"
reaction,
utilizing
an
additional
step
without
changing
solvent,
sequential-addition
procedure,
limit
number
of
steps,
while
increasing
complexity
and
molecular
diversity,
highly
step-economical
reactions.
The
Ugi
one
most
common
multicomponent
reactions,
has
recently
fascinated
chemists
high
diversity
brought
by
its
four-
three-component-based
isonitrile.
reaction
been
introduced
organic
synthesis
as
novel,
efficient
useful
tool
for
preparation
libraries
multifunctional
peptides,
natural
products,
heterocyclic
stereochemistry
control.
In
this
review,
we
highlight
recent
advances
last
decades
from
2000-2019,
mainly
linear
cyclic
versatile
ring
sizes,
well
enantioselective
Meanwhile,
applications
these
pharmaceutical
trials
also
discussed.
RSC Advances,
Journal Year:
2025,
Volume and Issue:
15(5), P. 3928 - 3953
Published: Jan. 1, 2025
This
review
studies
magnetically
recoverable
catalysts
designed
for
the
efficient
multicomponent
synthesis
of
organosulfur
compounds.
These
enhance
process
by
combining
efficiency
with
environmental
sustainability.
Molecules,
Journal Year:
2021,
Volume and Issue:
27(1), P. 132 - 132
Published: Dec. 27, 2021
In
this
review,
we
comprehensively
describe
catalyzed
multicomponent
reactions
(MCRs)
and
the
multiple
roles
of
catalysis
combined
with
key
parameters
to
perform
these
transformations.
Besides
improving
yields
shortening
reaction
times,
is
vital
achieving
greener
protocols
furthering
MCR
field
research.
Considering
that
MCRs
typically
have
two
or
more
possible
pathways
explain
transformation,
essential
for
selecting
a
route
avoiding
byproduct
formation.
Key
parameters,
such
as
temperature,
catalyst
amounts
reagent
quantities,
were
analyzed.
Solvent
effects,
which
are
likely
most
neglected
topic
in
MCRs,
well
their
catalysis,
critically
discussed.
Stereocontrolled
rarely
observed
without
presence
catalytic
system,
also
presented
discussed
review.
Perspectives
on
use
systems
improved
finally
presented.
ACS Catalysis,
Journal Year:
2022,
Volume and Issue:
12(9), P. 5510 - 5516
Published: April 25, 2022
We
developed
an
efficient
visible-light-mediated
formal
carbene
insertion
reaction
of
1,3-diketones
with
diazoesters
for
the
construction
enantioenriched
1,4-dicarbonyl
compounds
a
quaternary
carbon
center.
Combining
visible
light
and
Brønsted
acid
catalyst,
chiral
were
achieved
in
good
yields
high
enantioselectivities
by
photochemical
transfer
protocol.
Scientific Reports,
Journal Year:
2022,
Volume and Issue:
12(1)
Published: May 23, 2022
Abstract
In
this
research,
cellulose
grafted
to
chitosan
by
EDTA
(Cs-EDTA-Cell)
bio-based
material
is
reported
and
characterized
a
series
of
various
methods
techniques
such
as
FTIR,
DRS-UV–Vis,
TGA,
FESEM,
XRD
EDX
analysis.
fact,
the
Cs-EDTA-Cell
network
more
thermally
stable
than
pristine
or
chitosan.
There
plenty
both
acidic
basic
sites
on
surface
biodegradable
network,
multifunctional
organocatalyst,
proceed
three-component
synthesis
2-amino-4
H
-pyran
derivatives
at
room
temperature
in
EtOH.
The
nanocatalyst
can
be
easily
recovered
from
reaction
mixture
using
filtration
reused
for
least
five
times
without
significant
decrease
its
catalytic
activity.
general,
heterogeneous
catalyst,
demonstrated
excellent
activity
an
environmentally-benign
solvent
afford
desired
products
short
required
simple
experimental
work-up
procedure
compared
many
protocols
similar
systems.
Organic & Biomolecular Chemistry,
Journal Year:
2023,
Volume and Issue:
21(17), P. 3477 - 3502
Published: Jan. 1, 2023
This
review
article
presents
an
in-depth
analysis
of
the
strategies
and
methodologies
for
using
chiral
phosphoric
acids
as
organocatalysts
in
asymmetric
syntheses
from
recent
literature.
ACS Catalysis,
Journal Year:
2021,
Volume and Issue:
11(19), P. 11938 - 11944
Published: Sept. 13, 2021
Catalytic
enantioselective
C–H
functionalization
has
recently
become
a
tool
for
the
creation
of
stereogenic
centers.
The
steep
increase
in
molecular
complexity
multicomponent
reactions
matches
very
well
with
asymmetric
functionalizations,
but
realization
such
processes
remains
large
challenge.
We
describe
diastereoselective
and
highly
three-component
catalyzed
by
an
earth-abundant
Co(III)
complex
equipped
chiral
cyclopentadienyl
ligand
(Cpx).
transformation
provides
rapid
access
to
substituted
β-hydroxyketones
using
three
readily
accessible
starting
materials.
outlined
reactivity
CpxCo(III)
catalysis
shows
higher
exploitable
propensity
selective
additions
across
carbonyls
contrast
chemistry
Rh(III).
ACS Catalysis,
Journal Year:
2022,
Volume and Issue:
12(7), P. 4046 - 4053
Published: March 16, 2022
Gold(I)
complexes
of
a
chiral
phosphoric
acid-functionalized
phosphine
the
CPA-Phos
series
enable
enantioselective
multicomponent
reactions
between
aldehydes,
hydroxylamines
and
cyclic
yne-enones,
leading
to
3,4-dihydro-1H-furo[3,4-d][1,2]oxazines.
This
represents
rare
example
highly
reaction
in
gold(I)
catalysis.
The
proceed
at
low
catalyst
loading
provide
high
yields,
total
diastereoselectivity,
enantiomeric
excesses
up
99%.
Silver-free
conditions
can
be
applied.
method
has
very
broad
scope
as
it
applies
both
aliphatic
aromatic
aldehydes
hydroxylamines,
variety
yne-enone-derived
oximes.
DFT
calculations
complement
this
study
enlighten
reactivity
issues
mechanistic
pathways.
ChemCatChem,
Journal Year:
2023,
Volume and Issue:
15(18)
Published: Aug. 3, 2023
Abstract
Asymmetric
multicomponent
reactions
are
considered
as
efficient
protocols
for
constructing
complex
chiral
molecules
because
of
their
step‐
and
atom‐economy.
Nickel‐catalyzed
asymmetric
three‐component
dicarbofunctionalization
alkenes
has
been
well
developed
in
recent
years,
which
is
used
the
area
total
synthesis
natural
products
late‐stage
modification
drugs
rapid
incorporation
sp
3
‐enriched
carbon
centers.
In
this
concept,
significant
breakthroughs
field
summarized,
together
with
related
mechanisms.
Moreover,
remaining
challenges
potential
opportunities
also
highlighted.
