Supported Metal Catalysts for the Synthesis of N-Heterocycles

Catalysts, Journal Year: 2022, Volume and Issue: 12(1), P. 68 - 68

Published: Jan. 9, 2022

Nitrogen-containing heterocycles are important scaffolds for a large number of compounds with biological, pharmaceutical, industrial and optoelectronic applications. A wide range different methodologies the preparation N-heterocycles based on metal-catalyzed cyclization suitable substrates. Due to growing interest in Green Chemistry criteria over past two decades, use supported metal catalysts has become central topic Organic Chemistry. Here we will give critical overview all solid applied synthesis N-heterocycles, following systematic approach as function type support: (i) inorganic matrices; (ii) organic (iii) hybrid inorganic-organic matrices. In particular, try emphasize effective heterogeneity recyclability described catalysts, specifying which studies were carried out order evaluate these aspects.

Language: Английский

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Oxidative Dehydrogenative Coupling of Arylamines with N-allyl and N-vinylamines for the Synthesis of Quinolines and 2-Methylquinoline Derivatives

Tetrahedron, Journal Year: 2025, Volume and Issue: unknown, P. 134450 - 134450

Published: Jan. 1, 2025

Language: Английский

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Metal-free three-component assemblies of anilines, α-keto acids and alkyl lactates for quinoline synthesis and their anti-inflammatory activity

Organic & Biomolecular Chemistry, Journal Year: 2022, Volume and Issue: 20(21), P. 4385 - 4390

Published: Jan. 1, 2022

A metal-free three-component protocol for quinoline synthesis is developed by using alkyl lactates, anilines and α-keto acids. In vitro experiments disclose the attractive anti-inflammatory activity of these compounds.

Language: Английский

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Schiff‐base Polymer Immobilized Ruthenium for Efficient Catalytic Cross‐coupling of Secondary Alcohols with 2‐amino‐ and γ‐aminobenzyl Alcohols to Give Quinolines and Pyridines

Chemistry - An Asian Journal, Journal Year: 2024, Volume and Issue: 19(7)

Published: Feb. 1, 2024

A Schiff-base porous polymer has been impregnated with ruthenium trichloride for acceptor-free dehydrogenation coupling (ADC) of secondary alcohols γ-amino- and 2-aminobenzyl to give pyridines quinolines. This heterogenous catalyst exhibited high catalytic efficiency over repeated cycles wide functional group tolerance.

Language: Английский

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Heterogeneous Pd-Catalyzed Efficient Synthesis of Imidazolones via Dehydrogenative Condensation between Ureas and 1,2-Diols

ACS Catalysis, Journal Year: 2022, Volume and Issue: 12(12), P. 6906 - 6922

Published: May 26, 2022

A heterogeneously catalyzed protocol for the acceptorless dehydrogenative condensation between N,N′-disubstituted ureas and 1,2-diols to afford imidazolones was developed. Palladium nanoaggregates stabilized onto an alumina matrix with suitable acidic properties, namely, [Pd/Al2O3], designed successfully applied as efficient reusable heterogeneous nanocatalyst this relevant transformation. The methodology developed showed its wide applicability through synthesis of more than 25 moderate good yields, reaching a turnover number (TON) up 19444 initial frequency (TOF0) > 290 h–1. active nanostructured catalyst fully characterized [X-ray diffraction (XRD), high-resolution transmission electron microscopy (HR-TEM), scanning (HR-STEM), energy-dispersive X-ray (EDX), Raman spectroscopy, temperature-programmed reduction (TPR), desorption (TPD)-NH3, TPD-CO2, photoelectron spectroscopy (XPS), Brunauer–Emmett–Teller (BET) area], mechanistic studies were performed. Moreover, other related Pd-based nanomaterials composed different or basic inorganic supports synthesized extensively compared in reaction. These revealed that presence Pd nanoparticles range sizes (average particle size 2.8 nm) over metal oxide support high density acid sites is key point activity material, γ-Al2O3 being optimum support. Furthermore, Pd–Zn cooperation effect described unactivated 1,2-diols, including ethylene glycol, ureas. Two bimetallic materials ([Pd/ZnO] [Pd(5%)–Zn(5%)/Al2O3]) also properly. materials, well [Pd/Al2O3] system combination catalytic amounts ZnO, selectivity 1,2-diols. nature all systems demonstrated, reusability catalysts proven.

Language: Английский

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Sustainable synthesis of azobenzenes, quinolines and quinoxalines via oxidative dehydrogenative couplings catalysed by reusable transition metal oxide–Bi(iii) cooperative catalysts

Catalysis Science & Technology, Journal Year: 2023, Volume and Issue: 13(10), P. 3069 - 3083

Published: Jan. 1, 2023

Heterogeneous catalytic oxidative dehydrogenative processes for N-heterocycles are presented, which enable waste-minimized (additive-, oxidant-, base-free), efficient cyclisations/couplings via transition metal oxide–Bi( iii ) cooperative catalysis.

Language: Английский

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Synthesis of indoles by dehydrodehydration and dehydration of aniline and ethylene glycol over Pt-based alumina catalysts

Journal of Organometallic Chemistry, Journal Year: 2024, Volume and Issue: 1011, P. 123112 - 123112

Published: March 23, 2024

Language: Английский

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Zinc Oxide (ZnO): an Amphoteric Metal Oxide with Dehydrogenating Activity

SynOpen, Journal Year: 2023, Volume and Issue: 07(02), P. 142 - 144

Published: March 28, 2023

Abstract

Language: Английский

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6-Amino-7-Azaindoles synthesis from 2,6-diamino pyridine and diols

Tetrahedron Letters, Journal Year: 2021, Volume and Issue: 84, P. 153460 - 153460

Published: Oct. 7, 2021

Language: Английский

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Polycyclic Aromatic N-Heterocycles (PANHs) from Naphthyl and Anthracenyl Amines and Diols

Synthesis, Journal Year: 2022, Volume and Issue: 54(23), P. 5226 - 5232

Published: June 7, 2022

Abstract Nitrogen-containing polyaromatic compounds have been prepared in one step by combining diols and anthracenyl or naphthyl amines via acceptorless dehydrogenative condensation with ZnO Pt/Al2O3 as heterogeneous catalysts.

Language: Английский

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