Chemical Communications,
Journal Year:
2022,
Volume and Issue:
58(95), P. 13230 - 13233
Published: Jan. 1, 2022
A
regioselective
Rh(III)-catalyzed
C-H
bond
naphthylation
and
cascade
directing
group
(DG)
transformation
has
been
realized
with
aryl
imidates
oxa
bicyclic
alkenes.
Diverse
naphthalene-substituted
aromatic
esters
were
synthesized
fruitfully.
The
DG
into
ester
endows
the
strategy
chances
of
further
functionalization
derivatization.
Preliminary
mechanistic
studies
demonstrate
that
carbonyl
oxygen
possibly
originates
from
corresponding
alkene.
ChemistrySelect,
Journal Year:
2022,
Volume and Issue:
7(22)
Published: June 9, 2022
Abstract
Five
membered
N
‐heterocycles
are
significant
targets
in
organic
synthesis
because
of
their
ubiquitous
existence
bioactive
natural
products
and
pharmaceuticals.
Over
the
past
decade
a
compelling
attractiveness
has
grown
to
develop
rhodium
complex
catalysed
efficient
atom‐economic
chemistry
access
structurally
diverse
‐heterocyclic
frameworks.
This
present
review
enlightens
notable
progresses
advances
5‐membered
via
cascade
reactions
(annulations,
C−H/C−C
activation,
cycloaddition,
rearrangement,
cyclization,
metathesis)
from
2018–2021.
Organic & Biomolecular Chemistry,
Journal Year:
2022,
Volume and Issue:
20(38), P. 7554 - 7576
Published: Jan. 1, 2022
With
respect
to
the
excellent
catalytic
performance,
directing-group
strategies
in
C–H
amination
catalyzed
by
rhodium
are
discussed
relation
types
of
aminating
reagent,
as
well
challenges
and
future
development
prospects.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(11), P. 1839 - 1844
Published: March 13, 2023
N-Heterocycle-assisted
C-H
activation/annulation
reactions
have
provided
new
concepts
for
the
construction
and
transformation
of
azacycles.
In
this
work,
we
disclose
a
[5+1]
annulation
reaction
using
novel
transformable
pyridazine
directing
group
(DG).
The
DG-transformable
mode
led
to
heterocyclic
ring
accompanied
by
original
via
activation/1,4-Rh
migration/double
bond
shift
pathway,
affording
skeleton
pyridazino[6,1-b]quinazolines
with
good
substrate
scope
under
mild
conditions.
Diverse
fused
cyclic
compounds
can
be
achieved
derivatization
product.
asymmetric
synthesis
was
also
realized
afford
enantiomeric
products
stereoselectivity.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 12, 2024
We
developed
a
cascade
C–H
activation/[3
+
2]
annulation
for
enaminones
and
vinylene
carbonate,
employing
the
catalyst
[Cp*RhCl
2
]
oxidants.
This
reaction
allows
efficient
synthesis
of
3-carbonylpyrroles.
The Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
87(15), P. 9988 - 10002
Published: July 13, 2022
We
report
an
atom-economic
Rh(III)-catalyzed
[3
+
2]-spiroannulation
reaction
between
cyclic
ketimines
and
α,β-unsaturated
carbonyl
compounds,
allowing
the
synthesis
of
novel
spirocycles
with
concomitant
generation
three
stereogenic
centers
in
one
pot.
The
does
not
require
any
silver
additives
or
external
oxidants
is
believed
to
proceed
a
redox-neutral
manner.
A
broad
substrate
scope
good
functional
group
tolerance
permitted
vast
spectrum
spirocyclic
1,4-benzoxazine
derivatives
containing
polysubstituted
α-aroyl-indanamines
excellent
yields
high
diastereoselectivity.
The Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
87(19), P. 12608 - 12621
Published: Sept. 9, 2022
An
external
oxidant
free
Ru(II)-catalyzed
C–H
functionalization/annulation
of
primary
benzylamines
with
sulfoxonium
ylides
has
been
developed
for
the
synthesis
isoquinolines.
The
reaction
utilizes
amine
as
a
directing
group,
which
is
generally
considered
to
be
poor
group.
This
work
presents
first
example
Ru-catalyzed
functionalization
under
redox-neutral
conditions.
detection
amine-directed
ruthenacyclic
intermediate
using
high-resolution
mass
spectrometry
corroborated
involvement
Organic & Biomolecular Chemistry,
Journal Year:
2022,
Volume and Issue:
20(11), P. 2293 - 2299
Published: Jan. 1, 2022
A
new
rhodium(
iii
)-catalyzed
multistep
cascade
spirocyclization
approach
was
developed
to
synthesize
a
novel
N
-acetyl
chain
of
spiropyrroloisoquinoline
derivatives
using
oxadiazoles
as
the
directing
group.
Organic Chemistry Frontiers,
Journal Year:
2022,
Volume and Issue:
9(11), P. 2939 - 2943
Published: Jan. 1, 2022
DTBP-mediated
oxidative
[4
+
2]/[3
2]
annulation
between
2-alkynylbenzaldehydes
and
arylalkenes
toward
benzo[
a
]fluoren-5-ones
under
metal-/solvent-free
conditions
is
presented.
