Functional Hydrogels as Wound Dressing to Enhance Wound Healing

ACS Nano, Journal Year: 2021, Volume and Issue: 15(8), P. 12687 - 12722

Published: Aug. 10, 2021

Hydrogels, due to their excellent biochemical and mechnical property, have shown attractive advantages in the field of wound dressings. However, a comprehensive review functional hydrogel as dressing is still lacking. This work first summarizes skin healing process relates evaluation parameters then reviews advanced functions dressings such antimicrobial adhesion hemostasis, anti-inflammatory anti-oxidation, substance delivery, self-healing, stimulus response, conductivity, recently emerged monitoring feature, strategies adopted achieve these are all classified discussed. Furthermore, applications for treatment different types wounds incisional excisional summarized. Chronic also mentioned, focus attention on infected wounds, burn diabetic Finally, future directions further proposed.

Language: Английский

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Conductive Biomaterials as Bioactive Wound Dressing for Wound Healing and Skin Tissue Engineering

Nano-Micro Letters, Journal Year: 2021, Volume and Issue: 14(1)

Published: Dec. 2, 2021

Abstract Conductive biomaterials based on conductive polymers, carbon nanomaterials, or inorganic nanomaterials demonstrate great potential in wound healing and skin tissue engineering, owing to the similar conductivity human skin, good antioxidant antibacterial activities, electrically controlled drug delivery, photothermal effect. However, a review highlights design application of for engineering is lacking. In this review, fabrication methods with various structural forms including film, nanofiber, membrane, hydrogel, sponge, foam, acellular dermal matrix applications corresponding mechanism promoting process were summarized. The approaches that realize their value wounds via three main strategies (electrotherapy, dressing, assessment) reviewed. as dressing when facing different acute chronic (infected diabetic wound) monitoring discussed detail. challenges perspectives designing developing multifunctional are proposed well.

Language: Английский

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pH/Glucose Dual Responsive Metformin Release Hydrogel Dressings with Adhesion and Self-Healing via Dual-Dynamic Bonding for Athletic Diabetic Foot Wound Healing

ACS Nano, Journal Year: 2022, Volume and Issue: 16(2), P. 3194 - 3207

Published: Jan. 31, 2022

In view of the lack a specific drug-sustained release system that is responsive to chronic wounds type II diabetic foot, and demands for frequent movement at foot wound, pH/glucose dual-responsive metformin-released adhesion-enhanced self-healing easy-removable antibacterial antioxidant conductive hemostasis multifunctional phenylboronic acid benzaldehyde bifunctional polyethylene glycol-co-poly(glycerol sebacic acid)/dihydrocaffeic l-arginine cografted chitosan (PEGS-PBA-BA/CS-DA-LAG, denoted as PC) hydrogel dressings were constructed based on double dynamic bond Schiff-base phenylboronate ester. It was further demonstrated PC promotes wound healing by reducing inflammation enhancing angiogenesis in rat model. addition, addition metformin (Met) graphene oxide (GO), well their synergy, confirmed better promote repair vivo. summary, PC/GO/Met hydrogels with stimuli-responsive ability easy removability have shown promoting effect athletic provide local-specific drug dual-response strategy treatment feet.

Language: Английский

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Hydrogel‐Based Flexible Electronics

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(14)

Published: Aug. 29, 2022

Abstract Flexible electronics is an emerging field of research involving multiple disciplines, which include but not limited to physics, chemistry, materials science, electronic engineering, and biology. However, the broad applications flexible are still restricted due several limitations, including high Young's modulus, poor biocompatibility, responsiveness. Innovative aiming for overcoming these drawbacks boost its practical application highly desirable. Hydrogel a class 3D crosslinked hydrated polymer networks, exceptional material properties render it as promising candidate next generation electronics. Here, latest methods synthesizing advanced functional hydrogels state‐of‐art hydrogel‐based in various fields reviewed. More importantly, correlation between hydrogel device performance discussed here, have better understanding development by using environmentally responsive hydrogels. Last, perspectives on current challenges future directions multifunctional provided.

Language: Английский

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Multifunctional Photoactive Hydrogels for Wound Healing Acceleration

ACS Nano, Journal Year: 2021, Volume and Issue: 15(12), P. 18895 - 18930

Published: Dec. 6, 2021

Light is an attractive tool that has a profound impact on modern medicine. Particularly, light-based photothermal therapy (PTT) and photodynamic (PDT) show great application prospects in the prevention of wound infection promoting healing. In addition, hydrogels have shown advantages field dressings due to their excellent biochemical effects. Therefore, multifunctional photoresponsive (MPRHs) integrate light are increasingly used biomedicine, especially repair. However, comprehensive review MPRHs for regeneration still lacking. This first focuses various types prepared by diverse photosensitizers, agents (PHTAs) including transition metal sulfide/oxides nanomaterials, nanostructure-based PHTAs, carbon-based conjugated polymer or complex-based and/or (PHDAs) such as ZnO-based, black-phosphorus-based, TiO2-based, small organic molecule-based PHDAs. We also then discuss how PTT, PDT, photothermal/photodynamic synergistic can modulate microenvironments bacteria inhibit infection. Overall, with both therapeutic tissue capabilities been discussed existing challenges, well future research directions management argued.

Language: Английский

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Recent advances in conductive hydrogels: classifications, properties, and applications

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 52(2), P. 473 - 509

Published: Dec. 9, 2022

Hydrogel-based conductive materials for smart wearable devices have attracted increasing attention due to their excellent flexibility, versatility, and outstanding biocompatibility. This review presents the recent advances in multifunctional hydrogels electronic devices. First, with different components are discussed, including pure single network based on polymers, additional additives (i.e., nanoparticles, nanowires, nanosheets), double additives. Second, a variety of functionalities, self-healing, super toughness, self-growing, adhesive, anti-swelling, antibacterial, structural color, hydrophobic, anti-freezing, shape memory external stimulus responsiveness introduced detail. Third, applications flexible illustrated strain sensors, supercapacitors, touch panels, triboelectric nanogenerator, bioelectronic devices, robot). Next, current challenges facing summarized. Finally, an imaginative but reasonable outlook is given, which aims drive further development future.

Language: Английский

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Antibacterial biomaterials for skin wound dressing

Asian Journal of Pharmaceutical Sciences, Journal Year: 2022, Volume and Issue: 17(3), P. 353 - 384

Published: Jan. 24, 2022

Bacterial infection and the ever-increasing bacterial resistance have imposed severe threat to human health. And contamination could significantly menace wound healing process. Considering sophisticated process, novel strategies for skin tissue engineering are focused on integration of bioactive ingredients, antibacterial agents included, into biomaterials with different morphologies improve cell behaviors promote healing. However, a comprehensive review anti-bacterial dressing enhance has not been reported. In this review, various as dressings will be discussed. Different kinds agents, including antibiotics, nanoparticles (metal metallic oxides, light-induced agents), cationic organic others, their recent advances summarized. Biomaterial selection fabrication structures forms, films, hydrogel, electrospun nanofibers, sponge, foam three-dimension (3D) printed scaffold regeneration, elaborated Current challenges future perspectives presented in multidisciplinary field. We envision that provide general insight elegant design further refinement dressing.

Language: Английский

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Recent Progress in External‐Stimulus‐Responsive 2D Covalent Organic Frameworks

Advanced Materials, Journal Year: 2021, Volume and Issue: 34(22)

Published: July 8, 2021

Recently, smart 2D covalent organic frameworks (COFs), combining the advantages of both inherent structure features and functional building blocks, have been demonstrated to show reversible changes in conformation, color, luminescence response external stimuli. This review provides a summary on recent progress COFs that are responsive stimuli such as metal ions, gas molecules, pH values, temperature, electricity, light, etc. Moreover, mechanisms design strategies, along with applications these stimulus-responsive chemical sensors photoelectronic devices also discussed. It is believed this would provide some guidelines for designing novel single-/multistimulus-responsive controllable behaviors advanced applications.

Language: Английский

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Engineering Smart Composite Hydrogels for Wearable Disease Monitoring

Nano-Micro Letters, Journal Year: 2023, Volume and Issue: 15(1)

Published: April 15, 2023

Growing health awareness triggers the public's concern about problems. People want a timely and comprehensive picture of their condition without frequent trips to hospital for costly cumbersome general check-ups. The wearable technique provides continuous measurement method monitoring by tracking person's physiological data analyzing it locally or remotely. During process, different kinds sensors convert signals into electrical optical that can be recorded transmitted, consequently playing crucial role in techniques. Wearable application scenarios usually require possess excellent flexibility stretchability. Thus, designing flexible stretchable with reliable performance is key technology. Smart composite hydrogels, which have tunable properties, mechanical biocompatibility, multi-stimulus sensitivity, are one best sensitive materials monitoring. This review summarizes common synthetic optimization strategies smart hydrogels focuses on current field

Language: Английский

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Supramolecular Thermo‐Contracting Adhesive Hydrogel with Self‐Removability Simultaneously Enhancing Noninvasive Wound Closure and MRSA‐Infected Wound Healing

Advanced Healthcare Materials, Journal Year: 2022, Volume and Issue: 11(13)

Published: April 15, 2022

Conventional wound closure and dressing are two crucial, time-consuming but isolated principles in care. Even though tissue adhesive opens a new era for closure, the method biomaterial that can simultaneously achieve noninvasive promote healing highly appreciated. Herein, novel supramolecular poly(N-isopropylacrylamide) hybrid hydrogel composed of quaternized chitosan-graft-β-cyclodextrin, adenine, polypyrrole nanotubes via host-guest interaction hydrogen bonds is developed. The demonstrates thermal contraction 47% remaining area after 2 h at 37 ℃ adhesion 5.74 kPa, which essential multiple mechanical biological properties including suitable properties, self-healing, on-demand removal, antioxidant, hemostasis, photothermal/intrinsic antibacterial activity (higher 99% killing ratio within 5 min irradiation). In both full-thickness skin incision excision models, reveals significant 24 post-surgery. acute methicillin-resistant Staphylococcus aureus-infected assays, wounds treated with demonstrate enhanced rapid rate, mild inflammatory response, advanced angiogenesis, well-arranged collagen fibers. Altogether, results indicate promising synchronously healing.

Language: Английский

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