Engineering Robust Ag‐Decorated Polydopamine Nano‐Photothermal Platforms to Combat Bacterial Infection and Prompt Wound Healing

Advanced Science, Journal Year: 2022, Volume and Issue: 9(11)

Published: Feb. 22, 2022

Polydopamine (PDA) nanoparticles have emerged as an attractive biomimetic photothermal agent in antibacterial therapy due to their ease of synthesis, good biodegradability, long-term safety, and excellent photostability. However, the therapeutic effects PDA are generally limited by low conversion efficiency (PCE). Herein, PDA@Ag synthesized via growing Ag on surface then encapsulated into a cationic guar gum (CG) hydrogel network. The optimized CG/PDA@Ag platform exhibits high PCE (38.2%), which is more than two times higher that pure (16.6%). More importantly, formulated with many active groups can capture kill bacteria through effective interactions between bacteria, thereby benefiting effect. As anticipated, designed system combined advantages (high PCE) (preventing aggregation possessing inherent ability) demonstrated superior efficacy both vitro vivo. This study develops facile approach boost for therapy, providing significant step forward advancing application nano-photothermal agents.

Language: Английский

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Structural and biological engineering of 3D hydrogels for wound healing

Bioactive Materials, Journal Year: 2022, Volume and Issue: 24, P. 197 - 235

Published: Dec. 23, 2022

Chronic wounds have become one of the most important issues for healthcare systems and are a leading cause death worldwide. Wound dressings necessary to facilitate wound treatment. Engineering may substantially reduce healing time, risk recurrent infections, disability costs associated. In path engineering an ideal dressing, hydrogels played role. Hydrogels 3D hydrophilic polymeric structures that can provide protective barrier, mimic native extracellular matrix (ECM), humid environment. Due their advantages, (with different architectural, physical, mechanical, biological properties) been extensively explored as dressing platforms. Here we describe recent studies on applications with strong focus interplay between fabrication method used performance achieved. Moreover, review categories additives which enhance regeneration using hydrogel dressings. Hydrogel promises generation smart solutions solve this pressing problem, enabling key functionalities such bacterial growth inhibition, enhanced re-epithelialization, vascularization, improved recovery tissue functionality, overall, accelerated effective healing.

Language: Английский

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All-in-one: Harnessing multifunctional injectable natural hydrogels for ordered therapy of bacteria-infected diabetic wounds

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 439, P. 135691 - 135691

Published: March 9, 2022

Language: Английский

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Injectable Self‐Healing Hydrogel Wound Dressing with Cysteine‐Specific On‐Demand Dissolution Property Based on Tandem Dynamic Covalent Bonds

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(19)

Published: March 3, 2021

Rapid gelation and on-demand dissolution are key characteristics governing the effectiveness of clinic hydrogel wound dressings. Here, an injectable self-healing with rapid cysteine-specific is designed to be used as The prepared based on formation tandem dynamic covalent bonds comprised CC double produced through catalysis-free Knoevenagel condensation reaction boronate ester linkages. displays excellent injectability ability, showing cysteine-triggered owing thiazolidino complex. When dressings for healing full-thickness wounds, shows favorable biocompatibility, achieves closure in seconds, fast dressing changes. These data highlight utility bonds-based promising applications.

Language: Английский

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Hydrogel Combined with Phototherapy in Wound Healing

Advanced Healthcare Materials, Journal Year: 2022, Volume and Issue: 11(16)

Published: June 25, 2022

Abstract Wound healing is a complex biological process that involves tissue regeneration. Traditional wound dressings are dry, cannot provide moist environment for healing, and do not have high antibacterial properties. Hydrogels, which capable of retaining large amounts water, can create environment. Currently, phototherapies exhibited potential the treatment bacterial infections. Therefore, combining hydrogels with phototherapy adequately overcome shortcomings traditional methods show great owing to their efficiency, low irritation, good performance. In this review, application combined in summarized. First, basic principles photodynamic therapy photothermal briefly introduced. addition, progress hydrogel systematically investigated. Finally, challenges prospects discussed.

Language: Английский

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Collagen-based formulations for wound healing: A literature review

Life Sciences, Journal Year: 2021, Volume and Issue: 290, P. 120096 - 120096

Published: Oct. 27, 2021

Language: Английский

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Biomimetic Hydrogels to Promote Wound Healing

Frontiers in Bioengineering and Biotechnology, Journal Year: 2021, Volume and Issue: 9

Published: Sept. 20, 2021

Wound healing is a common physiological process which consists of sequence molecular and cellular events that occur following the onset tissue lesion in order to reconstitute barrier between body external environment. The inherent properties hydrogels allow damaged heal by supporting hydrated environment has long been explored wound management aid autolytic debridement. However, chronic non-healing wounds require added therapeutic features can be achieved incorporation biomolecules cells promote faster better outcomes. In recent decades, numerous have developed modified match time scale for distinct stages healing. This review will discuss effects various types on pathophysiology, as well ideal characteristics healing, crosslinking mechanism, fabrication techniques design considerations hydrogel engineering. Finally, several challenges related adopting future perspectives are discussed.

Language: Английский

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Recent trends on burn wound care: hydrogel dressings and scaffolds

Biomaterials Science, Journal Year: 2021, Volume and Issue: 9(13), P. 4523 - 4540

Published: Jan. 1, 2021

Biomaterial -based therapy in burn wound care and the roles advantages of hydrogels.

Language: Английский

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Anti-inflammation biomaterial platforms for chronic wound healing

Biomaterials Science, Journal Year: 2021, Volume and Issue: 9(12), P. 4388 - 4409

Published: Jan. 1, 2021

Chronic wound has developed into one of the most serious health problems worldwide; rate-limiting stage chronic healing is inflammation stage; we reviewed advances and impact various anti-inflammatory biomaterial platforms.

Language: Английский

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Multifunctional Hydrogels for the Healing of Diabetic Wounds

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 13(1)

Published: Sept. 13, 2023

Abstract The healing of diabetic wounds is hindered by various factors, including bacterial infection, macrophage dysfunction, excess proinflammatory cytokines, high levels reactive oxygen species, and sustained hypoxia. These factors collectively impede cellular behaviors the process. Consequently, this review presents intelligent hydrogels equipped with multifunctional capacities, which enable them to dynamically respond microenvironment accelerate wound in ways, stimuli ‐responsiveness, injectable self‐healing, shape ‐memory, conductive real‐time monitoring properties. relationship between multiple functions also discussed. Based on wounds, antibacterial, anti‐inflammatory, immunomodulatory, antioxidant, pro‐angiogenic strategies are combined hydrogels. application repair systematically discussed, aiming provide guidelines for fabricating exploring role therapeutic processes.

Language: Английский

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