MXenes Antibacterial Properties and Applications: A Review and Perspective

Small, Journal Year: 2023, Volume and Issue: 19(14)

Published: Jan. 5, 2023

The mutations of bacteria due to the excessive use antibiotics, and generation antibiotic-resistant have made development new antibacterial compounds a necessity. MXenes emerged as biocompatible transition metal carbide structures with extensive biomedical applications. This is related MXenes' unique combination properties, including multifarious elemental compositions, 2D-layered structure, large surface area, abundant terminations, excellent photothermal photoelectronic properties. focus this review application MXenes, which has attracted attention researchers since 2016. A quick overview synthesis strategies provided then summarizes effect various factors (including structural optical charges, flake size, dispersibility) on biocidal activity MXenes. main mechanisms for deactivating by are discussed in detail rupturing bacterial membrane sharp edges nanoflakes, generating reactive oxygen species (ROS), bacteria. Hybridization other organic inorganic materials can result improved activities different applications such wound dressings water purification. Finally, challenges perspectives MXene nanomaterials agents presented.

Language: Английский

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Advances and challenges in conductive hydrogels: From properties to applications

European Polymer Journal, Journal Year: 2022, Volume and Issue: 177, P. 111454 - 111454

Published: July 30, 2022

Language: Английский

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Recent advances in engineered polymeric materials for efficient photodynamic inactivation of bacterial pathogens

Bioactive Materials, Journal Year: 2022, Volume and Issue: 21, P. 157 - 174

Published: Aug. 21, 2022

Nowadays, infectious diseases persist as a global crisis by causing significant destruction to public health and the economic stability of countries worldwide. Especially bacterial infections remain most severe concern due prevalence emergence multi-drug resistance (MDR) limitations with existing therapeutic options. Antibacterial photodynamic therapy (APDT) is potential modality that involves systematic administration photosensitizers (PSs), light, molecular oxygen (O2) for coping infections. Although porphyrin non-porphyrin PSs were effective in APDT, poor solubility, limited efficacy against Gram-negative bacteria, non-specific distribution hinder their clinical applications. Accordingly, promote efficiency conventional PSs, various polymer-driven modification functionalization strategies have been adopted engineer multifunctional hybrid phototherapeutics. This review assesses recent advancements state-of-the-art research polymer-PSs materials developed APDT Further, key findings following aspects are considered in-depth constructive discussions: i) PSs-integrated/functionalized polymeric composites through interactions; ii) PSs-deposited coatings on different substrates devices eliminate healthcare-associated infections; iii) PSs-embedded films, scaffolds, hydrogels regenerative medicine

Language: Английский

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Novel bi-layered dressing patches constructed with radially-oriented nanofibrous pattern and herbal compound-loaded hydrogel for accelerated diabetic wound healing

Applied Materials Today, Journal Year: 2022, Volume and Issue: 28, P. 101542 - 101542

Published: June 4, 2022

Language: Английский

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Biomimetic Asymmetric Composite Dressing by Electrospinning with Aligned Nanofibrous and Micropatterned Structures for Severe Burn Wound Healing

ACS Applied Materials & Interfaces, Journal Year: 2022, Volume and Issue: 14(29), P. 32799 - 32812

Published: July 15, 2022

The surface structure and topography of biomaterials play a crucial role in directing cell behaviors fates. Meanwhile, asymmetric dressings that mimic the natural skin have been identified as an effective strategy for enhancing wound healing. Inspired by superhydrophobic lotus leaf, composite dressing was obtained constructing wettability modification on both sides sponge based electrospinning. Among them, collagen quaternized chitosan fabricated freeze-drying, followed aligned poly(ε-caprolactone) (PCL)/gelatin nanofiber hydrophilic inner layer hierarchical micronanostructure PCL/polystyrene microsphere highly hydrophobic outer constructed each side sponge. proposed combines topological morphology with material's properties to effectively prevent bacterial colonization/infection promote healing cellular behavior. In vitro experimental results confirmed promotes adhesion, proliferation, directed growth, migration. has good water absorption antibacterial properties, while biomimetic exhibits strong mechanical resistance adhesion. vivo showed can reduce inflammatory response, infection, accelerate angiogenesis epithelial regeneration, significantly severe burns. Thus, bionic is expected be promising candidate burn

Language: Английский

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Bioinspired multifunctional injectable hydrogel for hemostasis and infected wound management

Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 161, P. 50 - 66

Published: Jan. 12, 2023

Language: Английский

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Recent Advances in Biodegradable and Biocompatible Synthetic Polymers Used in Skin Wound Healing

Materials, Journal Year: 2023, Volume and Issue: 16(15), P. 5459 - 5459

Published: Aug. 3, 2023

The treatment of skin wounds caused by trauma and pathophysiological disorders has been a growing healthcare challenge, posing great economic burden worldwide. use appropriate wound dressings can help to facilitate the repair healing rate defective skin. Natural polymer biomaterials such as collagen hyaluronic acid with excellent biocompatibility have shown promote restoration However, low mechanical properties fast degradation limited their applications. Skin based on biodegradable biocompatible synthetic polymers not only overcome shortcomings natural but also possess favorable for applications in wounds. Herein, we listed several used dressing materials, PVA, PCL, PLA, PLGA, PU, PEO/PEG, focusing composition, fabrication techniques, functions promoting healing. Additionally, future development prospects polymer-based are put forward. Our review aims provide new insights further using polymers.

Language: Английский

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Chitosan-based self-healing hydrogel dressing for wound healing

Advances in Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 332, P. 103267 - 103267

Published: Aug. 3, 2024

Language: Английский

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Click‐hydrogel delivered aggregation‐induced emissive nanovesicles for simultaneous remodeling and antibiosis of deep burn wounds

Aggregate, Journal Year: 2023, Volume and Issue: 5(1)

Published: Aug. 17, 2023

Abstract As a high‐risk trauma, deep burns are always hindered in their repair process by decreased tissue regeneration capacity and persistent infections. In this study, we developed simultaneous strategy for burn wounds treatment using functional nanovesicles with antibacterial remodeling properties, delivered via click‐chemistry hydrogel. An aggregation‐induced emission photosensitizer of 4‐(2‐(5‐(4‐(diphenylamino)phenyl)thiophen‐2‐yl)vinyl)‐1‐(2‐hydroxyethyl) pyridin‐1‐ium bromide (THB) excellent photodynamic properties was first prepared, then combined readily accessible adipose stem cells‐derived to generate the THB functionalized (THB@ANVs). The THB@ANVs showed strong activity against Gram‐positive bacteria (up 100% killing rate), also beneficial effects on remodeling, including promoting cell migration, proliferation, regulating immunity. addition, prepared click‐hydrogel carboxymethyl chitosan effective delivery wounds. This hydrogel could be injected conform wound morphology while responding acidic microenvironment. vivo evaluations healing revealed that dressing efficiently accelerated second‐degree reducing bacterial growth, inflammation, early angiogenesis, collagen deposition. study provides promising candidate diverse functions repair.

Language: Английский

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Design Considerations, Formulation Approaches, and Strategic Advances of Hydrogel Dressings for Chronic Wound Management

ACS Omega, Journal Year: 2023, Volume and Issue: 8(9), P. 8172 - 8189

Published: Feb. 20, 2023

Wound healing is a complex and dynamic physiological process consisting of series cellular molecular events that initiate immediately after tissue lesion, to reconstruct the skin layer. It indubitable patients with chronic wounds, severely infected or any metabolic disorder wound microenvironment always endure severe pain discomfort affect their quality life. essential treat wounds for conserving physical as well mental well-being affected convalescing improve For supporting augmenting process, selection pertinent dressing essential. A substantial reduction in duration, disability, associated cost, risk recurrent infections can be achieved via engineering dressings. Hydrogels play leading role path ideal Hydrogels, comprising water large extent, providing moist environment, being comfortable patients, having biocompatible biodegradable properties, have found success suitable dressings market. The exploitation hydrogels increasing perpetually substantiation broader therapeutic actions owing resemblance dermal tissues, capability stimulate partial regeneration, ability incorporate moieties promoting healing. This review entails properties hydrogel healing, types hydrogels, cross-linking mechanisms, design considerations, formulation strategies engineering. Various categories fabricated recently are discussed based on gel network composition, degradability, chemical which provide an outlook regarding importance tailoring physicochemical hydrogels. examples marketed also incorporated along future perspectives challenges them.

Language: Английский

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