Epilepsy: Mitochondrial connections to the ‘Sacred’ disease DOI Creative Commons
Walter H. Moos, Douglas V. Faller,

Ioannis P. Glavas

et al.

Mitochondrion, Journal Year: 2023, Volume and Issue: 72, P. 84 - 101

Published: Aug. 13, 2023

Over 65 million people suffer from recurrent, unprovoked seizures. The lack of validated biomarkers specific for myriad forms epilepsy makes diagnosis challenging. Diagnosis and monitoring childhood add to the need non-invasive biomarkers, especially when evaluating antiseizure medications. Although underlying mechanisms epileptogenesis are not fully understood, evidence mitochondrial involvement is substantial. Seizures affect 35%-60% patients diagnosed with diseases. Mitochondrial dysfunction pathophysiological in various epilepsies, including those non-mitochondrial origin. Decreased ATP production caused by malfunctioning brain cell mitochondria leads altered neuronal bioenergetics, metabolism neurological complications, Iron-dependent lipid peroxidation initiates ferroptosis, a death pathway that aligns morphology found neurodegenerative diseases (NDDs). Studies mouse genetic models seizure phenotypes where function an essential selenoprotein (GPX4) targeted suggest roles ferroptosis epilepsy. GPX4 pivotal NDDs, selenium protects interneurons ferroptosis. Selenium central nervous system micronutrient trace element. Low serum concentrations other elements minerals, iron, noted diagnosing supplements alleviate intractable seizures children reduced GPX activity. Copper cuproptosis, like iron link NDDs. Connecting these mechanistic pathways selenoproteins provides new insights into treating seizures, pointing using medicines prodrugs lipoic acid treat potential alternative therapeutic approaches transcranial magnetic stimulation (transcranial), photobiomodulation vagus nerve stimulation.

Language: Английский

A lysosome-targeted fluorescent probe for fluorescence imaging of hypochlorous acid in living cells and in vivo DOI
Ke An, Jiaxin Fan, Bin Lin

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2024, Volume and Issue: 316, P. 124316 - 124316

Published: April 19, 2024

Language: Английский

Citations

8
Butyrylcholinesterase-Activated Near-Infrared Fluorogenic Probe for In Vivo Theranostics of Alzheimer’s Disease DOI
Lei Wang, Tianyu Sun,

Tengfei Zhen

et al.

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(8), P. 6793 - 6809

Published: March 28, 2024

Butyrylcholinesterase (BChE) is a promising biomarker and effective therapeutic target for Alzheimer's disease (AD). Herein, we designed BChE-activated near-infrared (NIR) probe,

Language: Английский

Citations

7
Rational design of cascade reaction-assisted trinal-site fluorescent probe for simultaneous discrimination of Cys, Hcy, GSH, and H2S in living cells and zebrafish DOI
Qian Wang, Wenting Zhang,

Mingzhe Cai

et al.

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 418, P. 136151 - 136151

Published: July 4, 2024

Language: Английский

Citations

7
Targeting Tumor Microenvironment by Metal Peroxide Nanoparticles in Cancer Therapy DOI Creative Commons
Simon N. Mbugua

Bioinorganic Chemistry and Applications, Journal Year: 2022, Volume and Issue: 2022(1)

Published: Jan. 1, 2022

Solid tumors have a unique tumor microenvironment (TME), which includes hypoxia, low acidity, and high hydrogen peroxide glutathione (GSH) levels, among others. These factors, offer favourable microenvironments nourishment for development spread, also serve as gateway specific successful cancer therapies. A good example is metal structures been synthesized utilized to enhance oxygen supply they shown great promise in the alleviation of hypoxia. In hypoxic environment, certain oxygen‐dependent treatments such photodynamic therapy radiotherapy fail respond therefore modulating has found antitumor impact drugs. Under acidic environments, produced by reaction peroxides with water not only induces oxidative stress but produces additional oxygen. This achieved since acts reactive substrate molecules catalyse enzymes, alleviating hypoxia observed microenvironment. Metal ions released process can distinct bioactivity their own right. used anticancer are rapidly evolving field, there evidence that option regulating therapy. this regard, synthesis mechanisms behind application specifically target highlighted review. Various characteristics TME angiogenesis, inflammation, acidity ion homeostasis addressed together forms synergistic combination treatments.

Language: Английский

Citations

26
Epilepsy: Mitochondrial connections to the ‘Sacred’ disease DOI Creative Commons
Walter H. Moos, Douglas V. Faller,

Ioannis P. Glavas

et al.

Mitochondrion, Journal Year: 2023, Volume and Issue: 72, P. 84 - 101

Published: Aug. 13, 2023

Over 65 million people suffer from recurrent, unprovoked seizures. The lack of validated biomarkers specific for myriad forms epilepsy makes diagnosis challenging. Diagnosis and monitoring childhood add to the need non-invasive biomarkers, especially when evaluating antiseizure medications. Although underlying mechanisms epileptogenesis are not fully understood, evidence mitochondrial involvement is substantial. Seizures affect 35%-60% patients diagnosed with diseases. Mitochondrial dysfunction pathophysiological in various epilepsies, including those non-mitochondrial origin. Decreased ATP production caused by malfunctioning brain cell mitochondria leads altered neuronal bioenergetics, metabolism neurological complications, Iron-dependent lipid peroxidation initiates ferroptosis, a death pathway that aligns morphology found neurodegenerative diseases (NDDs). Studies mouse genetic models seizure phenotypes where function an essential selenoprotein (GPX4) targeted suggest roles ferroptosis epilepsy. GPX4 pivotal NDDs, selenium protects interneurons ferroptosis. Selenium central nervous system micronutrient trace element. Low serum concentrations other elements minerals, iron, noted diagnosing supplements alleviate intractable seizures children reduced GPX activity. Copper cuproptosis, like iron link NDDs. Connecting these mechanistic pathways selenoproteins provides new insights into treating seizures, pointing using medicines prodrugs lipoic acid treat potential alternative therapeutic approaches transcranial magnetic stimulation (transcranial), photobiomodulation vagus nerve stimulation.

Language: Английский

Citations

16