Exploring the Application of Micellar Drug Delivery Systems in Cancer Nanomedicine

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(3), P. 433 - 433

Published: March 12, 2023

Various formulations of polymeric micelles, tiny spherical structures made materials, are currently being investigated in preclinical and clinical settings for their potential as nanomedicines. They target specific tissues prolong circulation the body, making them promising cancer treatment options. This review focuses on different types materials available to synthesize well ways that micelles can be tailored responsive stimuli. The selection stimuli-sensitive polymers used micelle preparation is based conditions found tumor microenvironment. Additionally, trends using treat presented, including what happens after they administered. Finally, various drug delivery applications involving discussed along with regulatory aspects future outlooks. As part this discussion, we will examine current research development field. challenges barriers may have overcome before widely adopted clinics also discussed.

Language: Английский

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Targeting Hypoxia-Inducible Factor-1 (HIF-1) in Cancer: Emerging Therapeutic Strategies and Pathway Regulation

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(2), P. 195 - 195

Published: Feb. 1, 2024

Hypoxia-inducible factor-1 (HIF-1) is a key regulator for balancing oxygen in the cells. It transcription factor that regulates expression of target genes involved homeostasis response to hypoxia. Recently, research has demonstrated multiple roles HIF-1 pathophysiology various diseases, including cancer. crucial mediator hypoxic and metabolism, thus contributing tumor development progression. Studies showed HIF-1α subunit significantly upregulated cancer cells promotes survival by mechanisms. In addition, potential progression, cell division, survival, proliferation, angiogenesis, metastasis. Moreover, role regulating cellular metabolic pathways, particularly anaerobic metabolism glucose. Given its significant it been an intriguing therapeutic research. Several compounds targeting HIF-1-associated processes are now being used treat different types This review outlines emerging strategies as well relevance regulation pathways addresses employment nanotechnology developing these promising strategies.

Language: Английский

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Gender Differences in Oxidative Stress in Relation to Cancer Susceptibility and Survival

Antioxidants, Journal Year: 2023, Volume and Issue: 12(6), P. 1255 - 1255

Published: June 11, 2023

Genetic, developmental, biochemical, and environmental variables interact intricately to produce sex differences. The significance of differences in cancer susceptibility is being clarified by numerous studies. Epidemiological research registries have revealed over the past few years that there are definite variations incidence, progression, survival. However, oxidative stress mitochondrial dysfunction also a significant impact on response treatment neoplastic diseases. Young women may be more protected from than men because most proteins implicated regulation redox state function under control sexual hormones. In this review, we describe how hormones activity antioxidant enzymes mitochondria, as well they affect several molecular pathways underlie gender-related discrepancies been identified better understood, which lead effective precision medicine vital information options for both males females with illnesses.

Language: Английский

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Stimuli responsiveness of recent biomacromolecular systems (concept to market): A review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 261, P. 129901 - 129901

Published: Feb. 3, 2024

Language: Английский

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Generation of Hydrogen Peroxide in Cancer Cells: Advancing Therapeutic Approaches for Cancer Treatment

Cancers, Journal Year: 2024, Volume and Issue: 16(12), P. 2171 - 2171

Published: June 7, 2024

Cancer cells show altered antioxidant defense systems, dysregulated redox signaling, and increased generation of reactive oxygen species (ROS). Targeting cancer through ROS-mediated mechanisms has emerged as a significant therapeutic strategy due to its implications in progression, survival, resistance. Extensive research focused on selective H2O2 for cell killing by employing various strategies such metal-based prodrugs, photodynamic therapy, enzyme-based nano-particle mediated approaches, chemical modulators, combination therapies. Many these H2O2-amplifying approaches have demonstrated promising anticancer effects selectivity preclinical investigations. They selectively induce cytotoxicity while sparing normal cells, sensitize resistant modulate the tumor microenvironment. However, challenges remain achieving selectivity, addressing heterogeneity, ensuring efficient delivery, managing safety toxicity. To address those issues, H2O2-generating agents been combined with other treatments leading optimized This review focuses agents/approaches that kill via H2O2-mediated mechanisms. Different categories compounds generate are summarized, their underlying function elucidated, clinical studies well recent advancements discussed, prospects targeted utility explored. By understanding potential compounds, researchers can pave way development effective personalized treatments.

Language: Английский

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Zinc‐Based ROS Amplifiers Trigger Cancer Chemodynamic/Ion Interference Therapy Through Self‐Cascade Catalysis

Small, Journal Year: 2024, Volume and Issue: unknown

Published: June 16, 2024

Abstract Nanozyme‐mediated chemodynamic therapy has emerged as a promising strategy due to its tumor specificity and controlled catalytic activity. However, the poor efficacy caused by low hydrogen peroxide (H 2 O ) levels in microenvironment (TME) poses challenges. Herein, an H self‐supplying nanozyme is constructed through loading peroxide‐like active platinum nanoparticles (Pt NPs) on zinc (ZnO (denoted ZnO @Pt). releases response acidic TME. Pt NPs catalyze hydroxyl radical generation from while reducing mitigation of oxidative stress glutathione, serving reactive oxygen (ROS) amplifier self‐cascade catalysis. In addition, Zn 2+ released interferes with cell energy supply metabolism, enabling ion interference synergize therapy. vitro studies demonstrate that @Pt induces cellular injury enhanced ROS release, downregulating ATP NAD + levels. vivo assessment anticancer effects showed could generate at sites induce apoptosis downregulate pathways associated glycolysis, resulting 89.7% reduction growth. This study presents TME‐responsive capable self‐supply therapy, providing paradigm for tumor‐specific design.

Language: Английский

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Tumor microenvironment responsive metal nanoparticles in cancer immunotherapy

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: July 27, 2023

Malignant tumors have a unique tumor microenvironment (TME), which includes mild acidity, hypoxia, overexpressed reactive oxygen species (ROS), and high glutathione (GSH) levels, among others. Recently, TME regulation approaches attracted widespread attention in cancer immunotherapy. Nanoparticles as drug delivery systems ability to modulate the hydrophilicity of drugs affect uptake efflux tumor. Especially, metal nanoparticles been extensive applied for immunotherapy due their physical properties elaborate design. However, potential deficiencies low biodegradability, toxicity treatment side effects restrict clinical application. In this review, we briefly introduce feature characteristics recent advances responsive addition, could be combined with other treatments, such chemotherapy, radiotherapy photodynamic therapy also is presented. Finally, challenges outlook improving antitumor efficiency, effect risks has discussed.

Language: Английский

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Advances in Nanodelivery Systems Based on Metabolism Reprogramming Strategies for Enhanced Tumor Therapy

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(6), P. 6689 - 6708

Published: Feb. 1, 2024

Tumor development and metastasis are closely related to the complexity of metabolism network. Recently, reprogramming strategies have attracted much attention in tumor therapy. Although there is preliminary success therapy agents, their therapeutic effects been restricted by effective reaching sites drugs. Nanodelivery systems with unique physical properties elaborate designs can specifically deliver tumors. In this review, we first summarize research progress nanodelivery based on enhance therapies depleting glucose, inhibiting glycolysis, lactic acid, lipid metabolism, glutamine glutathione, disrupting metal metabolisms combined other therapies, including chemotherapy, radiotherapy, photodynamic therapy, etc. We further discuss detail advantages for As well as opportunities challenges integrating into analyze outlook these emerging areas. This review expected improve our understanding modulating enhanced

Language: Английский

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MXenes as theranostics: Diagnosis and therapy including in vitro and in vivo applications

Applied Materials Today, Journal Year: 2023, Volume and Issue: 35, P. 102002 - 102002

Published: Nov. 25, 2023

Language: Английский

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Improved photocatalytic disinfection performance of graphitic carbon nitride through hybridization with humic acid /zinc peroxide: A synergistic generation of antimicrobial reactive oxygen species

Journal of Photochemistry and Photobiology A Chemistry, Journal Year: 2024, Volume and Issue: 452, P. 115577 - 115577

Published: March 4, 2024

Language: Английский

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