MAPK/NF-κB signaling mediates atrazine-induced cardiorenal syndrome and antagonism of lycopene DOI
Fuwei Jiang, Jianying Guo,

Jia Lin

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 922, P. 171015 - 171015

Published: Feb. 16, 2024

Language: Английский

Ferroptosis is critical for phthalates driving the blood-testis barrier dysfunction via targeting transferrin receptor DOI Creative Commons
Yi Zhao,

Hao Zhang,

Jia-Gen Cui

et al.

Redox Biology, Journal Year: 2022, Volume and Issue: 59, P. 102584 - 102584

Published: Dec. 22, 2022

The global rate of human male infertility is rising at an alarming owing to environmental and lifestyle changes. Phthalates are the most hazardous chemical additives in plastics have apparently negative impact on function reproductive system. Ferroptosis a recently described form iron-dependent cell death has been linked several diseases. Transferrin receptor (TfRC), specific ferroptosis marker, universal iron importer for all cells using extracellular transferrin. We aim investigate potential involvement during toxicity, provide means drawing conclusions effect phthalates-induced disease. In this study, we found that di (2-ethylhexyl) phthalate (DEHP) triggered blood-testis barrier (BTB) dysfunction mouse testicular tissues. DEHP also induced mitochondrial morphological changes lipid peroxidation, which manifestations ferroptosis. As primary metabolite DEHP, mono-2-ethylhexyl (MEHP) by inhibiting glutathione defense network increasing peroxidation. TfRC knockdown blocked MEHP-induced decreasing intracellular levels Fe2+. Our findings indicate can regulate Sertoli therefore novel therapeutic molecule disorders patients with infertility.

Language: Английский

Citations

99
Phthalate-induced testosterone/androgen receptor pathway disorder on spermatogenesis and antagonism of lycopene DOI
Yi Zhao,

Xue‐Nan Li,

Hao Zhang

et al.

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 439, P. 129689 - 129689

Published: July 27, 2022

Language: Английский

Citations

85
Di-2-ethylhexyl phthalate (DEHP) induced lipid metabolism disorder in liver via activating the LXR/SREBP-1c/PPARα/γ and NF-κB signaling pathway DOI Open Access

Yue-Qiang Huang,

Yi-Xi Tang,

Bai-Hao Qiu

et al.

Food and Chemical Toxicology, Journal Year: 2022, Volume and Issue: 165, P. 113119 - 113119

Published: May 7, 2022

Language: Английский

Citations

79
Lycopene prevents Di-(2-ethylhexyl) phthalate-induced mitophagy and oxidative stress in mice heart via modulating mitochondrial homeostasis DOI
Yue Shen,

Lin Liu,

Muzi Li

et al.

The Journal of Nutritional Biochemistry, Journal Year: 2023, Volume and Issue: 115, P. 109285 - 109285

Published: Feb. 14, 2023

Language: Английский

Citations

42
Phthalates Induce Neurotoxicity by Disrupting the Mfn2-PERK Axis-Mediated Endoplasmic Reticulum–Mitochondria Interaction DOI
Yi Zhao, Yuan‐Hang Chang,

Hao-Ran Ren

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(13), P. 7411 - 7422

Published: Feb. 23, 2024

Di-(2-ethylhexyl) phthalate (DEHP), as the most common phthalate, has been extensively used a plasticizer to improve plasticity of agricultural products, which pose severe harm human health. Mitochondrial dynamics and endoplasmic reticulum (ER) homeostasis are indispensable for maintaining mitochondria-associated ER membrane (MAM) integrity. In this study, we aimed explore effect DEHP on nervous system its association with ER-mitochondria interaction. Here, showed that caused morphological changes, motor deficits, cognitive impairments, blood-brain barrier disruption in brain. triggered stress, is mainly mediated by protein kinase R-like (PERK) signaling. Moreover, DEHP-induced mitofusin-2 (Mfn2) downregulation results imbalance mitochondrial dynamics. Interestingly, exposure impaired MAMs inhibiting Mfn2-PERK Above all, study elucidates axis-mediated interaction phthalate-induced neurotoxicity could be potentially developed novel therapy neurological diseases.

Language: Английский

Citations

26
Lycopene mitigates DEHP-induced hepatic mitochondrial quality control disorder via regulating SIRT1/PINK1/mitophagy axis and mitochondrial unfolded protein response DOI
Yi Zhao, Huixin Li, Yu Luo

et al.

Environmental Pollution, Journal Year: 2021, Volume and Issue: 292, P. 118390 - 118390

Published: Oct. 25, 2021

Language: Английский

Citations

77
DEHP-induced mitophagy and mitochondrial damage in the heart are associated with dysregulated mitochondrial biogenesis DOI
Hao Zhang, Yi Zhao,

Jia-Gen Cui

et al.

Food and Chemical Toxicology, Journal Year: 2022, Volume and Issue: 161, P. 112818 - 112818

Published: Jan. 13, 2022

Language: Английский

Citations

49
Lycopene alleviates di(2-ethylhexyl) phthalate-induced splenic injury by activating P62-Keap1-NRF2 signaling DOI
Xueyan Dai,

Shi‐Yong Zhu,

Jian Chen

et al.

Food and Chemical Toxicology, Journal Year: 2022, Volume and Issue: 168, P. 113324 - 113324

Published: July 31, 2022

Language: Английский

Citations

48
Comparison of antagonistic effects of nanoparticle-selenium, selenium-enriched yeast and sodium selenite against cadmium-induced cardiotoxicity via AHR/CAR/PXR/Nrf2 pathways activation DOI
Jing Ge, Kai Guo, Yan Huang

et al.

The Journal of Nutritional Biochemistry, Journal Year: 2022, Volume and Issue: 105, P. 108992 - 108992

Published: March 22, 2022

Language: Английский

Citations

45
Di-(2-ethyl hexyl) phthalate induced oxidative stress promotes microplastics mediated apoptosis and necroptosis in mice skeletal muscle by inhibiting PI3K/AKT/mTOR pathway DOI
Xiaojing Liu, Yilei Zhang, Xinyue Sun

et al.

Toxicology, Journal Year: 2022, Volume and Issue: 474, P. 153226 - 153226

Published: May 1, 2022

Language: Английский

Citations

39