Gut microbiota-SCFAs-brain axis associated with the antidepressant activity of berberine in CUMS rats

Journal of Affective Disorders, Journal Year: 2023, Volume and Issue: 325, P. 141 - 150

Published: Jan. 5, 2023

Language: Английский

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Direct and indirect effects of pathogenic bacteria on the integrity of intestinal barrier

Therapeutic Advances in Gastroenterology, Journal Year: 2023, Volume and Issue: 16

Published: Jan. 1, 2023

Bacterial translocation is a pathological process involving migration of pathogenic bacteria across the intestinal barrier to enter systemic circulation and gain access distant organs. This phenomenon has been linked diverse range diseases including inflammatory bowel disease, pancreatitis, cancer. The an innate structure that maintains homeostasis. Pathogenic infections dysbiosis can disrupt integrity barrier, increasing its permeability, thereby facilitating pathogen translocation. As represents essential step in pathogenesis, clear understanding how disrupted this disruption facilitates bacterial could identify new routes effective prophylaxis therapy. In comprehensive review, we provide in-depth analysis function. We discuss currently understood mechanisms bacterial-enterocyte interactions, with focus on tight junctions endocytosis. also emerging concept bidirectional communication between microbiota other body systems. tract established 'axes' various Among our regulatory systems, nervous, immune, endocrine systems have shown play pivotal roles regulation. A mechanistic regulation crucial for development personalized management strategies patients translocation-related disorders. Advancing knowledge will pave way future research field novel clinical intervention strategies.

Language: Английский

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Synergistic effects of plant polysaccharides and exercise on depression alleviation from the microbiota-gut-brain axis

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 105967 - 105967

Published: Jan. 1, 2025

Language: Английский

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A comprehensive review on bioavailability, safety and antidepressant potential of natural bioactive components from tea

Food Research International, Journal Year: 2022, Volume and Issue: 158, P. 111540 - 111540

Published: June 21, 2022

Language: Английский

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Possible Effects and Mechanisms of Dietary Natural Products and Nutrients on Depression and Anxiety: A Narrative Review

Antioxidants, Journal Year: 2022, Volume and Issue: 11(11), P. 2132 - 2132

Published: Oct. 28, 2022

Depression and anxiety are severe public health problems have attracted more attention from researchers of food science nutrition. Dietary natural products nutrients, such as fish, coffee, tea, n-3 PUFA, lycopene, dietary fiber, could play a vital role in the prevention management these diseases. The potential mechanisms action mainly include inhibiting inflammation, ameliorating oxidative stress, modulating microbiota–gut–brain axis, suppressing hypothalamic–pituitary–adrenal axis hyperactivity, regulating levels monoamine neurotransmitters. In this narrative review, we summarize most recent advancements regarding effects nutrients on depression anxiety, their underlying discussed. We hope that paper can provide better understanding anti-depressive anxiolytic products, it is also helpful for developing functional food, supplements, or auxiliary agents

Language: Английский

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Relationship between Dietary Polyphenols and Gut Microbiota: New Clues to Improve Cognitive Disorders, Mood Disorders and Circadian Rhythms

Foods, Journal Year: 2023, Volume and Issue: 12(6), P. 1309 - 1309

Published: March 19, 2023

Cognitive, mood and sleep disorders are common intractable of the central nervous system, causing great inconvenience to lives those affected. The gut–brain axis plays a vital role in studying neurological such as neurodegenerative diseases by acting channel for bidirectional information exchange between gut microbiota system. Dietary polyphenols have received widespread attention because their excellent biological activity wide range sources, structural diversity low toxicity. intervention through increased intake dietary is an emerging strategy improving circadian rhythms treating metabolic disorders. been shown play essential regulating intestinal flora, mainly maintaining balance flora enhancing host immunity, thereby suppressing pathologies. This paper reviewed interactions brain effects on focusing that regulate maintain health system axis.

Language: Английский

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Cryptotanshinone regulates gut microbiota and PI3K-AKT pathway in rats to alleviate CUMS induced depressive symptoms

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 169, P. 115921 - 115921

Published: Nov. 26, 2023

Cryptotanshinone (CPT), a bioactive compound derived from the traditional Chinese herb Salvia miltiorrhiza, exhibits promising antidepressant properties. Employing rat model subjected to Chronic Unpredictable Mild Stress (CUMS), behavioral analyses (open field experiment, elevated cross maze sugar water preference forced swimming experiment) and inflammatory factor assessments were conducted assess efficacy of CPT in alleviating depressive symptoms responses induced by CUMS. Moreover, 16 S rDNA analysis revealed alterations gut microbiota rats exposed both CUMS administration. Notably, administration was found mitigate harmful bacterial shifts associated with depression. Preliminary exploration molecular mechanism underlying CPT's effects via transcriptomics docking indicated that might exert its influence regulating PI3K-AKT pathway. This study sheds light on potential therapeutic role managing disorders, offering comprehensive understanding impact behavior, inflammation, microbiota, pathways.

Language: Английский

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Effects of chronic unpredictable mild stress on gut microbiota and fecal amino acid and short-chain fatty acid pathways in mice

Behavioural Brain Research, Journal Year: 2024, Volume and Issue: 464, P. 114930 - 114930

Published: March 2, 2024

Language: Английский

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Uncovering the effects and mechanisms of tea and its components on depression, anxiety, and sleep disorders: A comprehensive review

Food Research International, Journal Year: 2024, Volume and Issue: 197, P. 115191 - 115191

Published: Oct. 18, 2024

Language: Английский

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The Intervention of Prebiotics on Depression via the Gut–Brain Axis

Molecules, Journal Year: 2022, Volume and Issue: 27(12), P. 3671 - 3671

Published: June 7, 2022

The imbalance of intestinal microbiota can cause the accumulation endotoxin in main circulation system human body, which has a great impact on health. Increased work and life pressure have led to rise number people falling into depression, also reduced their quality life. gut–brain axis (GBA) is closely related pathological basis improve depressive symptoms through GBA. Previous studies proven that prebiotics modulate thus participate health regulation. We reviewed regulatory mechanism depression GBA, discussed effects prebiotics, including plant polysaccharides polyphenols regulation microbiota, providing new clues for prevention treatment depression.

Language: Английский

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