Natural products target pyroptosis for ameliorating neuroinflammation: A novel antidepressant strategy

Phytomedicine, Journal Year: 2025, Volume and Issue: 138, P. 156394 - 156394

Published: Jan. 14, 2025

Language: Английский

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Effects of Lutjanus erythropterus Protein on Depression-like Behavior and Gut Microbiota in Stressed Juvenile Mice

Foods, Journal Year: 2025, Volume and Issue: 14(2), P. 330 - 330

Published: Jan. 20, 2025

Lutjanus erythropterus protein (Lep) exhibits anti-inflammatory effects, but its antidepressant activity is unknown. This study used a 44-day chronic unpredictable mild stress (CUMS) model to determine whether Lep has beneficial effect through the gut–brain axis in 3-week-old male C57BL/6 mice. Gavaging with solution alleviated depression-like behavior and anxiety symptoms CUMS growing Administration of decreased serum IL-1β, IL-2, IL-6, TNF-α levels restored colonic mucosal damage. In addition, improved disturbance 5-hydroxytryptamine (5-HT) secretion axis. Pearson analysis revealed that gut short-chain fatty acid (SCFAs) concentration significantly (p < 0.05) correlated damage scores index. was able prevent SCFA enrichment. upregulated Muribaculaceae downregulated SCFA-producing bacteria by replenishing deficient amino (AA) (tryptophan, alanine, aspartate, glutamate) 0.01) gene abundance AA metabolism pathway bacteria, thereby preventing enrichment alleviating associated behavior. These findings indicate could attenuate depression juvenile mice via microbiota-SCFA–brain

Language: Английский

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Effects of tea polyphenols and tea polysaccharides on improving nonylphenol-induced depression-like behavior, monoamine neurotransmitter disorder, and neuronal pyroptosis

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 295, P. 118166 - 118166

Published: April 1, 2025

Exposure to nonylphenol (NP) has been linked depressive-like behaviors, while tea consumption is associated with a reduced risk of depression. This study investigates and compares the effects polyphenols (TPs) polysaccharides (TPSs) in alleviating NP-induced focusing on neuronal apoptosis disrupted monoamine neurotransmitter secretion. Thirty-two specific-pathogen-free male, Sprague-Dawley rats (age: 4 weeks) were randomly assigned four groups: control (5 mL/kg corn oil), NP (40 mg/kg NP), NP+TPS (25 TPS), NP+TP (50 TP) groups. The group exhibited shorter latency period feeding test than group. Both groups showed immobility time tail suspension forced swimming tests. accumulation midbrain cortical tissues was lower these two Additionally, an increased number "pear-shaped" neurons higher serum levels. also demonstrated expression estrogen receptor β (ERβ), tryptophan hydroxylase (TPH1), hydroxylase-2 (TPH2), 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid (5-HIAA) at both protein gene These progressive increase neuron counts, more organized arrangement, nuclear staining intensity compared Moreover, their IL-1β IL-18 levels lower, along reduction Iba-1-positive microglia. rate, apoptotic cells, apoptosis-related inflammatory proteins (NLRP3, GSDMD, Caspase-1) decreased TP TPS mitigate behaviors by significantly reducing apoptosis, normalizing secretion, neuroinflammation. findings highlight potential components as neuroprotective agents against environmental endocrine disruptor-induced

Language: Английский

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Efficacy of paeoniflorin on models of depression: A systematic review and meta-analysis of rodent studies

Journal of Ethnopharmacology, Journal Year: 2022, Volume and Issue: 290, P. 115067 - 115067

Published: Feb. 8, 2022

Language: Английский

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Lavender essential oil alleviates depressive-like behavior in alcohol-withdrawn rats: Insights from gut metabolites and hippocampal transcriptome analysis

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 176, P. 116835 - 116835

Published: May 28, 2024

Lavender, an aromatic plant with a history dating back to ancient Egypt and Greece, is consumed because of its diverse pharmacological properties, including sedation, sleep aid, antidepressant effects. However, the mechanisms underlying these properties remain unclear. In this study, we explored impact lavender essential oil (LEO) inhalation on diversity gut microbiota, metabolites, differential gene expression in hippocampus alcohol-withdrawn depressive rats. Additionally, examined alterations hippocampal transient receptor potential (TRP) channel-mediated inflammatory regulation within brain-gut axis The results demonstrated significant decrease sucrose preference, diminished activity central zone open field test, prolonged immobility time forced swim test rats, indicating amelioration states following inhalation. 16 S rDNA sequencing analysis revealed reduction Bacteroidota Muribaculaceae whereas significantly increased relative abundance other bacterial species. Metabolomic identified 646 distinct metabolites as highly correlated biomarkers between model groups. Furthermore, attenuated factors IL-2, IL-6, IL-1β, TNF-α. This study elevated Trpv4 Calml4 region depressed rats showed that regulated aberrantly expressed genes. Our research suggests downregulates Trpv4, modulates factors, alleviates depressive-like behavior alcohol withdrawal

Language: Английский

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Study on the antidepressive effects and mechanism of raw and fried Ziziphi Spinosae Semen via metabolomics and gut microbiota analysis

Biomedical Chromatography, Journal Year: 2024, Volume and Issue: 38(7)

Published: April 8, 2024

Abstract Ziziphi Spinosae Semen (ZSS) and fried ZSS (FZSS) have been used for treating insomnia depression in China. However, the potential influence of chemical variations on their efficacy remains unclear. This study demonstrated that compared with ZSS, FZSS exhibited an increase content seven compounds, while fatty oil decreased. Both antidepressive effects a chronic unpredictable mild stress rat model, indicating synergistic regulation deficiencies 5‐hydroxytryptamine brain hyperactivation severe peripheral inflammation. superior modulatory effect FZSS, as indicated by integrated pharmacodynamic index, metabolic profile, relative distance value. The mechanism underlying involved modulation gut microbiota structure to alleviate excessive inflammatory responses imbalanced tryptophan metabolism. Correlation analysis higher contents should be comprehensively considered main reason ZSS's effects, achieved through pyroglutamic acid levels.

Language: Английский

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Adenosine regulates depressive behavior in mice with chronic social defeat stress through gut microbiota

Neuropharmacology, Journal Year: 2024, Volume and Issue: 262, P. 110209 - 110209

Published: Nov. 6, 2024

Language: Английский

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Hyperactivity in the Hypothalamic-Pituitary-Adrenal Axis: An Invisible Killer for Anxiety and/or Depression in Coronary Artherosclerotic Heart Disease

Journal of Integrative Neuroscience, Journal Year: 2024, Volume and Issue: 23(12)

Published: Dec. 24, 2024

The coexistence of anxiety or depression with coronary heart disease (CHD) is a significant clinical challenge in cardiovascular medicine. Recent studies have indicated that hypothalamic-pituitary-adrenal (HPA) axis activity could be promising focus understanding and addressing the development treatments for comorbid CHD depression. HPA helps to regulate levels inflammatory factors, thereby reducing oxidative stress damage, promoting platelet activation, stabilizing gut microbiota, which enhance survival regeneration neurons, endothelial cells, other cell types, leading neuroprotective cardioprotective benefits. This review addresses relevance nervous systems, as well latest research advancements regarding its mechanisms action. discussion includes detailed function regulating processes mentioned. Above all, it summarizes therapeutic potential biomarker atherosclerotic combined

Language: Английский

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Nutraceuticals and Physical Activity as Antidepressants: The Central Role of the Gut Microbiota

Antioxidants, Journal Year: 2022, Volume and Issue: 11(2), P. 236 - 236

Published: Jan. 26, 2022

Major depressive disorder (MDD) is a common mental illness. Evidence suggests that the gut microbiota play an essential role in regulating brain functions and pathogenesis of neuropsychiatric diseases, including MDD. There are numerous mechanisms through which can exchange information continuous, bidirectional communication. Current research emphasizes interexchange signals influenced by detected transduced from to nervous system involving neural, endocrine, inflammatory mechanisms, suggesting relationship between oxidative stress pathophysiology MDD via hyperactivation responses. Potential sources inflammation plasma hippocampus depressed individuals could stem increases intestinal permeability. Some nutraceuticals, such as specific probiotics, namely psychobiotics, polyphenols, carotenoids, butyrate, prebiotics, have been demonstrated exert antidepressant activity, but most them need be metabolized activated microorganisms. By inducing changes composition, physical exercise might also alleviating depression-like symptoms. The mutual relationships among exercise, depression will discussed, potential therapeutic target treat explored.

Language: Английский

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Amelioration impact of gut-brain communication on obesity control by regulating gut microbiota composition through the ingestion of animal-plant-derived peptides and dietary fiber: can food reward effect as a hidden regulator?

Critical Reviews in Food Science and Nutrition, Journal Year: 2023, Volume and Issue: 64(31), P. 11575 - 11589

Published: Aug. 1, 2023

Various roles of intestinal flora in the gut-brain axis response pathway have received enormous attention because their unique position flora-derived metabolites regulating hormones, inducing appetite, and modulating energy metabolism. Reward pathways brain play a crucial role communications, but mechanisms not been methodically understood. This review outlined by which leptin, ghrelin, insulin are influenced to regulate appetite body weight, focused on significance paraventricular nucleus ventromedial prefrontal cortex food reward. The vagus nerve mitochondria essential involved modulation neurotransmitters, neural signaling, neurotransmission communications. dynamic nutrient intake changes characteristics feeding activity requires participation transmit messages be completed. SCFAs, Bas, BCAAs, induced hormones mediate sensory information reward signaling host complex regulatory mechanism selection, composition significantly impacts this process. Food process obesity based communications expands new ideas for prevention treatment obesity.

Language: Английский

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