Journal of Food Science,
Journal Year:
2023,
Volume and Issue:
88(9), P. 3967 - 3983
Published: Aug. 7, 2023
Accumulating
evidence
suggests
that
specific
probiotic
strains
exert
hypoglycemic
effects
on
type
2
diabetes
mellitus
(T2DM),
and
within
Bifidobacterium
exhibit
potential
beneficial
T2DM.
In
this
study,
α-glucosidase
inhibitory
activities
of
14
were
assessed
in
vitro.
The
longum
WHH2270
with
high
activity
(42.03%)
then
investigated
a
high-fat
diet/streptozotocin-induced
T2DM
rat
model.
Oral
administration
(4
×
109
CFU/kg/day)
for
8
weeks
significantly
reversed
the
reduced
body
weight
ameliorated
levels
fasting
blood
glucose,
serum
triglyceride,
total
cholesterol,
glucose
tolerance,
insulin
resistance
rats.
Using
16S
rRNA
high-throughput
sequencing
feces,
was
revealed
to
reshape
gut
microbiome
composition
by
increasing
abundances
Lactobacillus
decreasing
UCG_005,
Clostridium,
Faecalibacterium
Besides,
fecal
short-chain
fatty
acids
(SCFAs)
including
acetate,
propionate,
butyrate
also
elevated
after
administration.
Moreover,
gene
expressions
SCFA
receptors
FFAR2
FFAR3
colon
pancreas
rats
restored
administration,
accompanied
increased
acetate.
summary,
these
results
provide
has
improve
symptoms
alleviating
hyperglycemia,
which
associated
changes
production.
PRACTICAL
APPLICATION:
may
serve
as
promising
agent
treatment
Pharmacological Research,
Journal Year:
2024,
Volume and Issue:
208, P. 107373 - 107373
Published: Aug. 26, 2024
Gastrointestinal
cancer
is
a
worldwide
health
challenge
due
to
its
dramatically
increasing
prevalence
and
as
leading
cause
of
cancer-related
mortality.
Increasing
evidence
has
illustrated
the
vital
role
gut
microbes-derived
metabolites
in
gastrointestinal
progression
treatment.
Microbial
are
produced
by
microbiota
that
utilizes
both
extrinsic
dietary
components
intrinsic
host-generated
compounds.
Meanwhile,
certain
categories
such
short-chain
fatty
acids,
bile
tryptophan,
indole
derivatives,
linked
malignancy.
In
this
review,
major
classes
microbial
their
impacts
on
various
cancers
including
colorectal
cancer,
gastric
hepatocellular
carcinoma,
have
been
introduced.
The
application
predictive
biomarkers
for
early
diagnosis
prognosis
also
explored.
addition,
therapeutic
potential
strategies
target
against
further
evaluated.
Frontiers in Nutrition,
Journal Year:
2022,
Volume and Issue:
9
Published: Sept. 30, 2022
Hyperuricemia
is
the
main
cause
of
gout
and
involved
in
occurrence
multiple
diseases,
such
as
hypertension,
metabolic
disorders
chronic
kidney
disease.
Emerging
evidence
suggests
that
lactic
acid
bacteria
(LAB)
have
shown
beneficial
effects
on
prevention
or
treatment
hyperuricemia.
In
this
study,
urate-lowering
effect
two
LAB
strains,
Lacticaseibacillus
rhamnosus
1155
(LR1155)
Limosilactobacillus
fermentum
2644
(LF2644)
hyperuricemic
rats
were
investigated.
A
rat
model
was
induced
by
intragastric
potassium
oxonate,
combined
with
a
high
purine
diet.
The
oral
administration
LR1155,
LF2644,
combination
LR1155
LF2644
for
4
weeks
significantly
prevented
rise
serum
uric
(UA)
elevated
fecal
UA
levels,
increased
content
up-regulated
gene
expression
transporter,
ATP-binding
cassette
subfamily
G-2
(ABCG2),
colon
jejunum
tissues,
suggesting
accelerated
excretion
from
intestine.
Besides,
inhibited
activity
xanthine
oxidase
(XOD)
liver
serum,
benefited
reduce
production.
addition,
strengthened
gut
barrier
functions
through
an
up-regulation
expressions
occluding
mucin2,
accompanied
reduced
inflammatory
indicators
lipopolysaccharide
(LPS)
interleukin-1β
(IL-1β)
rat.
Moreover,
using
16s
rDNA
high-throughput
sequencing
feces,
to
improve
hyperuricemia
microbial
dysbiosis.
genera
Roseburia,
Butyricicoccus,
Prevotella,
Oscillibacter,
Bifidobacterium
may
associate
microbiota
rats.
Collectively,
results
indicated
exhibit
could
be
used
alone
new
adjuvant
Microorganisms,
Journal Year:
2023,
Volume and Issue:
11(7), P. 1787 - 1787
Published: July 11, 2023
This
literature
review
aimed
to
collect
investigations
on
the
in
vivo
evidence
for
bacteria
associated
with
fermented
dairy
foods
behave
as
probiotics
beneficial
effects
prevention
and
treatment
of
various
diseases.
All
main
bacterial
groups
commonly
present
high
numbers
milks
or
cheeses
were
taken
into
account,
namely
starter
lactic
acid
(SLAB)
Lactobacillus
delbrueckii
subsp.
bulgaricus
lactis,
L.
helveticus,
Lactococcus
Streptococcus
thermophilus,
non-starter
LAB
(NSLAB)
Lacticaseibacillus
spp.,
Lactiplantibacillus
plantarum,
propionibacteria,
other
less
frequently
encountered
species.
Only
studies
regarding
strains
proven
origin
considered.
Studies
animal
models
clinical
showed
that
ameliorate
symptoms
inflammatory
bowel
disease
(IBD),
mucositis,
metabolic
syndrome,
aging
oxidative
stress,
cancer,
bone
diseases,
atopic
dermatitis,
allergies,
infections
damage
caused
by
pollutants,
mild
depression.
Immunomodulation
changes
intestinal
microbiota
mechanisms
most
often
involved
observed
effects.
The
results
considered
indicated
milk
products
are
a
rich
source
should
be
further
exploited
advantage
human
health.
Journal of Food Science,
Journal Year:
2023,
Volume and Issue:
88(9), P. 3967 - 3983
Published: Aug. 7, 2023
Accumulating
evidence
suggests
that
specific
probiotic
strains
exert
hypoglycemic
effects
on
type
2
diabetes
mellitus
(T2DM),
and
within
Bifidobacterium
exhibit
potential
beneficial
T2DM.
In
this
study,
α-glucosidase
inhibitory
activities
of
14
were
assessed
in
vitro.
The
longum
WHH2270
with
high
activity
(42.03%)
then
investigated
a
high-fat
diet/streptozotocin-induced
T2DM
rat
model.
Oral
administration
(4
×
109
CFU/kg/day)
for
8
weeks
significantly
reversed
the
reduced
body
weight
ameliorated
levels
fasting
blood
glucose,
serum
triglyceride,
total
cholesterol,
glucose
tolerance,
insulin
resistance
rats.
Using
16S
rRNA
high-throughput
sequencing
feces,
was
revealed
to
reshape
gut
microbiome
composition
by
increasing
abundances
Lactobacillus
decreasing
UCG_005,
Clostridium,
Faecalibacterium
Besides,
fecal
short-chain
fatty
acids
(SCFAs)
including
acetate,
propionate,
butyrate
also
elevated
after
administration.
Moreover,
gene
expressions
SCFA
receptors
FFAR2
FFAR3
colon
pancreas
rats
restored
administration,
accompanied
increased
acetate.
summary,
these
results
provide
has
improve
symptoms
alleviating
hyperglycemia,
which
associated
changes
production.
PRACTICAL
APPLICATION:
may
serve
as
promising
agent
treatment
