Smart/stimuli-responsive hydrogels: Cutting-edge platforms for tissue engineering and other biomedical applications

Materials Today Bio, Journal Year: 2021, Volume and Issue: 13, P. 100186 - 100186

Published: Dec. 9, 2021

Recently, biomedicine and tissue regeneration have emerged as great advances that impacted the spectrum of healthcare. This left door open for further improvement their applications to revitalize impaired tissues. Hence, restoring functions. The implementation therapeutic protocols merge biomimetic scaffolds, bioactive molecules, cells plays a pivotal role in this track. Smart/stimuli-responsive hydrogels are remarkable three-dimensional (3D) bioscaffolds intended engineering other biomedical purposes. They can simulate physicochemical, mechanical, biological characters innate Also, they provide aqueous conditions cell growth, support 3D conformation, mechanical stability cells, serve potent delivery matrices molecules. Many natural artificial polymers were broadly utilized design these intelligent platforms with novel advanced characteristics tailored functionalities fit such applications. In present review, we highlighted different types smart/stimuli-responsive emphasis on synthesis scheme. Besides, mechanisms responsiveness stimuli elaborated. Their potential was discussed. Furthermore, exploitation targeted drug delivery, smart biosensors, actuators, 4D printing, culture outlined. addition, threw light self-healing biomedicine. Eventually, presented future perceptions Conclusively, current progress enhances prospective function intelligent, sophisticated systems

Language: Английский

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Hydrogels Classification According to the Physical or Chemical Interactions and as Stimuli-Sensitive Materials

Gels, Journal Year: 2021, Volume and Issue: 7(4), P. 182 - 182

Published: Oct. 25, 2021

Hydrogels are attractive biomaterials with favorable characteristics due to their water uptake capacity. However, hydrogel properties determined by the cross-linking degree and nature, tacticity, crystallinity of polymer. These can be sorted out according internal structure response external factors. In this case, interaction reversible when chains led physicochemical interactions. physical hydrogels synthesized through several techniques such as crystallization, amphiphilic copolymers, charge interactions, hydrogen bonds, stereo-complexing, protein contrast, irreversible covalent cross-linking. Synthesized chemical interactions present a high density employed using graft copolymerization, reactive functional groups, enzymatic methods. Moreover, specific smart have also been denoted response, pH, temperature, electric, light, enzyme. This review deeply details type hydrogel, either or response. Furthermore, we detail some main applications these in biomedicine field, drug delivery systems, scaffolds for tissue engineering, actuators, biosensors, many other applications.

Language: Английский

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Biomedical applications of hydrogels in drug delivery system: An update

Journal of Drug Delivery Science and Technology, Journal Year: 2021, Volume and Issue: 66, P. 102914 - 102914

Published: Oct. 14, 2021

Language: Английский

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Recent insights into polysaccharide-based hydrogels and their potential applications in food sector: A review

International Journal of Biological Macromolecules, Journal Year: 2022, Volume and Issue: 213, P. 987 - 1006

Published: June 12, 2022

Language: Английский

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Novel Trends in Hydrogel Development for Biomedical Applications: A Review

Polymers, Journal Year: 2022, Volume and Issue: 14(15), P. 3023 - 3023

Published: July 26, 2022

Nowadays, there are still numerous challenges for well-known biomedical applications, such as tissue engineering (TE), wound healing and controlled drug delivery, which must be faced solved. Hydrogels have been proposed excellent candidates these they promising properties the mentioned including biocompatibility, biodegradability, great absorption capacity tunable mechanical properties. However, depending on material or manufacturing method, resulting hydrogel may not up to specific task it is designed, thus different approaches enhance performance requirements of application in question. The main purpose this review article was summarize most recent trends technology, going through used polymeric materials popular synthesis methods years, strategies enhancing hydrogels' properties, cross-linking manufacture composite hydrogels. In addition, secondary objective briefly discuss other novel applications hydrogels that past few years drawn a lot attention.

Language: Английский

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Natural Hydrogel-Based Bio-Inks for 3D Bioprinting in Tissue Engineering: A Review

Gels, Journal Year: 2022, Volume and Issue: 8(3), P. 179 - 179

Published: March 14, 2022

Three-dimensional (3D) printing is well acknowledged to constitute an important technology in tissue engineering, largely due the increasing global demand for organ replacement and regeneration. In 3D bioprinting, which a step ahead of biomaterial printing, ink employed impregnated with cells, without compromising printability. This allows immediate scaffold cellularization generation complex structures. The use cell-laden inks or bio-inks provides opportunity enhanced cell differentiation fabrication Recognizing importance such bio-inks, current study comprehensively explores state art utilization based on natural polymers (biopolymers), as cellulose, agarose, alginate, decellularized matrix, bioprinting. Discussions regarding progress techniques approaches bioprinting polymers, limitations prospects concerning future trends human-scale are also presented.

Language: Английский

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Production of Polymer Hydrogel Composites and Their Applications

Journal of Polymers and the Environment, Journal Year: 2023, Volume and Issue: 31(7), P. 2855 - 2879

Published: March 15, 2023

Abstract Hydrogels are three-dimensional cross-linked stable network insoluble in water, which gives them a remarkable capacity to absorb both water and biological fluids. Hydrogel has been synthesized from natural or synthetic polymers and/or monomers, have made tremendous advancements many different applications. Composite hydrogel is type of prepared by grafting hydrophilic groups, such as hydroxyl (–OH), carboxylic acid (–COOH), imide (–CONH), sulfonic (–SO 3 H), amine (–NH 2 ), amide (–CONH into the polymer chain’s backbone adding some additives kaolin, zeolite, even types nanoparticles. Whereas polymeric composite hydrogels exhibit stimuli for properties pH, temperature, light, may affect swelling, mechanical properties, self-healing, turn play vital roles areas. Hence, numerous efforts synthesize polymer-based composited via physical chemical crosslinking techniques enhance their physiochemical, biological, other properties. Many researchers currently paying attention applications, including wastewater treatment purification, medical biomedical agricultural industrial The aim this review summarize classification based on techniques, addition used prepare hydrogels. Furthermore, impact health environment discussed. Other significant issues were also presented, challenges that face production application,

Language: Английский

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Smart/stimuli-responsive hydrogels: State-of-the-art platforms for bone tissue engineering

Applied Materials Today, Journal Year: 2022, Volume and Issue: 29, P. 101560 - 101560

Published: June 22, 2022

Language: Английский

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Antibacterial smart hydrogels: New hope for infectious wound management

Materials Today Bio, Journal Year: 2022, Volume and Issue: 17, P. 100499 - 100499

Published: Nov. 19, 2022

Millions of people die annually due to uncured wound infections. Healthcare systems incur high costs treat Tt is predicted become more challenging the rise multidrug-resistant conditions. During last decades, smart antibacterial hydrogels could attract attention as a promising solution, especially for skin These are termed 'smart' their response specific physical and chemical environmental stimuli. To deliver different drugs particular sites in controlled manner, various types crosslinking strategies used manufacturing process. Smart designed provide antimicrobial agents infected or built from polymers with inherent disinfectant properties. This paper aims critically review recent pre-clinical clinical advances using against infections propose next best thing future trends. For this purpose, an introduction healing disease presented intelligent responding stimuli introduced. Finally, most investigations discussed related sections. studies can pave way producing new biomaterials applications.

Language: Английский

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Stimuli-responsive dynamic hydrogels: design, properties and tissue engineering applications

Materials Horizons, Journal Year: 2023, Volume and Issue: 10(9), P. 3325 - 3350

Published: Jan. 1, 2023

This review provides a brief overview of the recent developments in hydrogel systems that respond dynamically to various stimuli, including some interesting fabrication strategies, and their application cardiac, bone, neural tissue regeneration.

Language: Английский

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