Recent progress of antibacterial hydrogels in wound dressings

Materials Today Bio, Journal Year: 2023, Volume and Issue: 19, P. 100582 - 100582

Published: Feb. 16, 2023

Hydrogels are essential biomaterials due to their favorable biocompatibility, mechanical properties similar human soft tissue extracellular matrix, and repair properties. In skin wound repair, hydrogels with antibacterial functions especially suitable for dressing applications, so novel hydrogel dressings have attracted widespread attention, including the design of components, optimization preparation methods, strategies reduce bacterial resistance, etc. this review, we discuss fabrication challenges associated crosslinking methods chemistry materials. We investigated advantages limitations (antibacterial effects mechanisms) different components in achieve good properties, response stimuli such as light, sound, electricity resistance. Conclusively, provide a systematic summary findings (crosslinking methods) an outlook on long-lasting effects, broader spectrum, diversified forms, future development prospects field.

Language: Английский

---

Antimicrobial Hydrogels: Potential Materials for Medical Application

Small, Journal Year: 2023, Volume and Issue: 20(5)

Published: Sept. 26, 2023

Abstract Microbial infections based on drug‐resistant pathogenic organisms following surgery or trauma and uncontrolled bleeding are the main causes of increased mortality from worldwide. The prevalence pathogens has led to a significant increase in medical costs poses great threat normal life people. This is an important issue field biomedicine, emergence new antimicrobial materials hydrogels holds promise for solving this problem. Hydrogel material with good biocompatibility, water absorption, oxygen permeability, adhesion, degradation, self‐healing, corrosion resistance, controlled release drugs as well structural diversity. Bacteria‐disturbing have applications direction surgical treatment, wound dressing, device coating, tissue engineering. paper reviews classification hydrogels, current status research, potential one application analyzes research biomedical five aspects: metal‐loaded drug‐loaded carbon‐material‐loaded fixed activity biological provides outlook high activity, biodegradability, injectability, clinical applicability future development prospects field.

Language: Английский

---

Innovations in hydrogel-based manufacturing: A comprehensive review of direct ink writing technique for biomedical applications

Advances in Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 324, P. 103095 - 103095

Published: Jan. 28, 2024

Direct ink writing (DIW) stands as a pioneering additive manufacturing technique that holds transformative potential in the field of hydrogel fabrication. This innovative approach allows for precise deposition inks layer by layer, creating complex three-dimensional structures with tailored shapes, sizes, and functionalities. By harnessing versatility hydrogels, DIW opens up possibilities applications spanning from tissue engineering to soft robotics wearable devices. comprehensive review investigates applied hydrogels its multifaceted applications. The paper introduces diverse range printing techniques while providing thorough exploration hydrogel-based printing. investigation aims explain progress made, challenges faced, trajectories lie ahead manufacturing. fundamental principles underlying are carefully examined, specifically focusing on rheological attributes parameters, prompting survey wide variety materials. These encompass both natural synthetic variations, all which can be effectively harnessed this purpose. Furthermore, explores latest biomedical areas, primary focus engineering, wound dressing, drug delivery systems. document not only consolidates existing state within context but also charts avenues further research breakthroughs.

Language: Английский

---

A pH responsive tannic acid/quaternized carboxymethyl chitosan/oxidized sodium alginate hydrogels for accelerated diabetic wound healing and real-time monitoring

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 264, P. 130741 - 130741

Published: March 7, 2024

Language: Английский

---

Multifaceted Hydrogel Scaffolds: Bridging the Gap between Biomedical Needs and Environmental Sustainability

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(27)

Published: June 2, 2024

Abstract Hydrogels are dynamically evolving 3D networks composed of hydrophilic polymer scaffolds with significant applications in the healthcare and environmental sectors. Notably, protein‐based hydrogels mimic extracellular matrix, promoting cell adhesion. Further enhancing proliferation within these matrix‐metalloproteinase‐triggered amino acid motifs. Integration cell‐friendly modules like peptides proteins expands hydrogel functionality. These exceptional properties position for diverse applications, including biomedicine, biosensors, remediation, food industry. Despite progress, there is ongoing research to optimize biomedical further. Engineering novel favorable characteristics crucial regulating tissue architecture facilitating ecological remediation. This review explores synthesis, physicochemical properties, biological implications various types their extensive biomedicine It elaborates on potential bridging gap between advancements sector solutions issues.

Language: Английский

---

Coral‐Inspired Hollow Microneedle Patch with Smart Sensor Therapy for Wound Infection

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(24)

Published: Feb. 20, 2024

Abstract Every year, over 12 million people are enduring the persistent pain resulting from wound infections. In these chronic wounds, concealed infections may be covered up by scabs or granulation, which impeding accurate diagnosis and treatment. To address such clinical challenges, inspired corals, a biomimetic microneedle patch (HepMi‐PCL) is developed to indicate treat within wound. Relying on high‐precision 3D printing technology, each polycaprolactone own an equally sized porous shell cavity with heparin‐based functional hydrogel filling in. After penetrating through scab, HepMi‐PCL can absorb exudate in surficial guide grooves pores microstructure its microneedle, thereby indicating whether anti‐infection needed. Upon identification of positive infection, will smartly activate release drugs rapidly. Subsequently, when infection effectively managed progressively decreases, drug delivery correspondingly slow down cease altogether. By leveraging autonomous response therapeutic capabilities, demonstrates potential expedite treatment infections, enhancement healing speed for infected wounds 200%. Thus, integration diagnostic functions anticipated offer novel approaches addressing management wounds.

Language: Английский

---

Hydrogels as a Potential Biomaterial for Multimodal Therapeutic Applications

Molecular Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 18, 2024

Hydrogels, composed of hydrophilic polymer networks, have emerged as versatile materials in biomedical applications due to their high water content, biocompatibility, and tunable properties. They mimic natural tissue environments, enhancing cell viability function. Hydrogels' physical properties allow for tailored antibacterial biomaterial, wound dressings, cancer treatment, engineering scaffolds. Their ability respond physiological stimuli enables the controlled release therapeutics, while porous structure supports nutrient diffusion waste removal, fostering regeneration repair. In healing, hydrogels provide a moist environment, promote migration, deliver bioactive agents antibiotics, healing process. For therapy, they offer localized drug delivery systems that target tumors, minimizing systemic toxicity improving therapeutic efficacy. Ocular therapy benefits from hydrogels' capacity form contact lenses maintain prolonged with eye surface, treatment outcomes various diseases. mucosal delivery, facilitate administration therapeutics across barriers, ensuring sustained improved bioavailability drugs. Tissue sees scaffolds extracellular matrix, supporting growth differentiation repairing damaged tissues. Similarly, bone regeneration, loaded factors stem cells osteogenesis accelerate healing. This article highlights some recent advances use applications, driven by be engineered specific needs interactive biological

Language: Английский

---

Recent advances of hydrogels as smart dressings for diabetic wounds

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(5), P. 1126 - 1148

Published: Jan. 1, 2024

This review highlights the latest progress of smart hydrogel dressings for bandaging, monitoring and therapy diabetic wounds.

Language: Английский

---

Polysaccharide- and protein-based hydrogel dressings that enhance wound healing: A review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 135482 - 135482

Published: Sept. 1, 2024

Language: Английский

---

Dual Self‐Assembly of Puerarin and Silk Fibroin into Supramolecular Nanofibrillar Hydrogel for Infected Wound Treatment

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(19)

Published: March 19, 2024

The treatment of infected wounds remains a challenging biomedical problem. Some bioactive small-molecule hydrogelators with unique rigid structures can self-assemble into supramolecular hydrogels for wound healing. However, they are still suffered from low structural stability and bio-functionality. Herein, hydrogel antibacterial dressing dual nanofibrillar network structure is proposed. A created by hydrogelator, puerarin extracted the traditional Chinese medicine Pueraria, interconnected secondary macromolecular silk fibroin induced Ga ions via charge-induced self-assembly. resulting features adequate mechanical strength sustainable retention at wounds. Good biocompatibility efficient bacterial inhibition obtained when ion concentration 0.05%. Otherwise, substantial release endows excellent hemostatic antioxidative properties. In vivo, evaluation mouse-infected model demonstrates that its healing effect outperformed commercially available silver-containing dressing. experimental group successfully achieves 100% closure rate on day 10. This study sheds new light design based self-assembly naturally derived molecules as well their clinical use treating chronic

Language: Английский

---