A Nonswelling Hydrogel with Regenerable High Wet Tissue Adhesion for Bioelectronics

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(18)

Published: Feb. 5, 2023

Reducing the swelling of tissue-adhesive hydrogels is crucial for maintaining stable tissue adhesion and inhibiting inflammation. However, reported strategies reducing always result in a simultaneous decrease adhesive strength hydrogel. Furthermore, once covalent bonds break currently hydrogels, they cannot be rebuilt, hydrogel loses its ability. In this work, nonswelling (named as "PAACP") possessing regenerable high synthesized by copolymerizing crosslinking poly(vinyl butyral) with acrylic acid, gelatin, chitosan-grafted N-acetyl-l-cysteine. The obtained PAACP reaches 211.4 kPa, which approximately ten times higher than that can reused multiple cycles. as-prepared shows great potential soft bioelectronics, muscle fatigue successfully monitored via electrode array strain sensor integrated on substrates. success these bioelectronics offers applicability long-term diagnosis muscle-related health conditions prosthetic manipulations.

Language: Английский

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Flexible and Stretchable Electrochemical Sensors for Biological Monitoring

Advanced Materials, Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 28, 2023

The rise of flexible and stretchable electronics has revolutionized biosensor techniques for probing biological systems. Particularly, electrochemical sensors (FSECSs) enable the in situ quantification numerous biochemical molecules different entities owing to their exceptional sensitivity, fast response, easy miniaturization. Over past decade, fabrication application FSECSs have significantly progressed. This review highlights key developments electrode functionalization. It delves into sensing various biomarkers, including metabolites, electrolytes, signaling molecules, neurotransmitters from systems, encompassing outer epidermis, tissues/organs vitro vivo, living cells. Finally, considering preparation applications, current challenges future opportunities are discussed.

Language: Английский

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Nanoporous graphene-based thin-film microelectrodes for in vivo high-resolution neural recording and stimulation

Nature Nanotechnology, Journal Year: 2024, Volume and Issue: 19(4), P. 514 - 523

Published: Jan. 11, 2024

Abstract One of the critical factors determining performance neural interfaces is electrode material used to establish electrical communication with tissue, which needs meet strict electrical, electrochemical, mechanical, biological and microfabrication compatibility requirements. This work presents a nanoporous graphene-based thin-film technology its engineering form flexible interfaces. The developed allows fabrication small microelectrodes (25 µm diameter) while achieving low impedance (∼25 kΩ) high charge injection (3–5 mC cm − 2 ). In vivo brain recording assessed in rodents reveals high-fidelity recordings (signal-to-noise ratio >10 dB for local field potentials), stimulation an intrafascicular implant demonstrates current thresholds (<100 µA) selectivity (>0.8) activating subsets axons within rat sciatic nerve innervating tibialis anterior plantar interosseous muscles. Furthermore, tissue biocompatibility devices was validated by chronic epicortical (12 week) intraneural (8 implantation. describes microelectrode potential high-precision high-resolution interfacing.

Language: Английский

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Graphene-Related Nanomaterials for Biomedical Applications

Nanomaterials, Journal Year: 2023, Volume and Issue: 13(6), P. 1092 - 1092

Published: March 17, 2023

This paper builds on the context and recent progress control, reproducibility, limitations of using graphene graphene-related materials (GRMs) in biomedical applications. The review describes human hazard assessment GRMs vitro vivo studies, highlights composition–structure–activity relationships that cause toxicity for these substances, identifies key parameters determine activation their biological effects. are designed to offer advantage facilitating unique applications impact different techniques medicine, especially neuroscience. Due increasing utilization GRMs, there is a need comprehensively assess potential health. Various outcomes associated with including biocompatibility, biodegradability, beneficial effects cell proliferation, differentiation rates, apoptosis, necrosis, autophagy, oxidative stress, physical destruction, DNA damage, inflammatory responses, have led an interest regenerative nanostructured materials. Considering existence nanomaterials physicochemical properties, expected exhibit modes interactions biomolecules, cells, tissues depending size, chemical composition, hydrophil-to-hydrophobe ratio. Understanding such crucial from two perspectives, namely, perspectives uses. main aim this study tune diverse properties must be considered when planning These include flexibility, transparency, surface chemistry (hydrophil–hydrophobe ratio), thermoelectrical conductibility, loading release capacity, biocompatibility.

Language: Английский

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Current and emerging strategies for biocompatible materials for implantable electronics

Cell Reports Physical Science, Journal Year: 2024, Volume and Issue: 5(8), P. 101852 - 101852

Published: March 5, 2024

The application of electronics to biological systems has rapidly developed over the last century, facilitating significant advances in diagnosis and therapy a large range conditions. electrodes within these devices are crucial component enabling high-quality, low noise signal recordings be achieved. However, most traditional materials used maximize electrical properties often at odds with need integrate interface successfully tissue. This review provides an overview current considerations, challenges, progress bypassing barriers vivo through material selection fabrication, by considering performance requirements implantable electrode practical limitations imposed fabrication technologies. We then summarize state-of-the-art emerging for electrodes.

Language: Английский

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High‐Performance MXene/PEDOT‐PSS Microscale Fiber Electrodes for Neural Recording and Stimulation

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Abstract The pursuit of advanced neural interfaces hinges on developing electrode materials with enhanced cathodic charge storage capacity (CSCc), injection (CIC), and low impedance. 2D nanomaterials, particularly MXenes, have emerged as leading candidates due to their outstanding electrical properties. However, current fabrication strategies not fully leveraged the potential MXene, limiting performance gains in recording stimulation applications. Here, a novel microscale fiber (MPP) engineered from Ti₃C₂ MXene PEDOT‐PSS using two‐step solidification wet spinning process is presented. These 30 µm fibers exhibit conductivity (2.16 ± 1.46) × 10⁵ S m −1 , interfacial impedance, high CSCc CIC, achieving substantial improvements signal fidelity efficiency. MPP electrodes demonstrate robust electrochemical stability, biocompatibility, magnetic resonance imaging (MRI) compatibility, excelling across various modalities, including electroencephalography (EEG), electromyography (EMG), electrocardiography (ECG), cortical recordings, subthalamic nucleus deep brain (STN‐DBS). results mark significant step toward scalable, high‐performance that can transform neurotherapeutic

Language: Английский

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Recent Advancements in the Fabrication of Functional Nanoporous Materials and Their Biomedical Applications

Materials, Journal Year: 2022, Volume and Issue: 15(6), P. 2111 - 2111

Published: March 13, 2022

Functional nanoporous materials are categorized as an important class of nanostructured because their tunable porosity and pore geometry (size, shape, distribution) unique chemical physical properties compared with other nanostructures bulk counterparts. Progress in developing a broad spectrum has accelerated use for extensive applications catalysis, sensing, separation, environmental, energy, biomedical areas. The purpose this review is to provide recent advances synthesis strategies designing ordered or hierarchical complex architectures. Furthermore, we briefly highlight working principles, potential pitfalls, experimental challenges, limitations associated material fabrication strategies. Finally, give forward look at how digitally controlled additive manufacturing may overcome existing obstacles guide the design development next-generation predefined industrial applications.

Language: Английский

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Double‐Microcrack Coupling Stretchable Neural Electrode for Electrophysiological Communication

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(37)

Published: May 24, 2023

Abstract Developing neural electrodes with high stretchability and stable conductivity is a promising method to explore applications of them in biological medicine electronic skin. However, considering the poor mechanical typical conductive materials, maintaining connection electrode paths under stretching still challenge. Herein, for first time, double‐microcrack coupling strategy highly stretchable proposed. Compared single‐layer microcrack electrodes, design utilizes complement between two gold films contribute more paths. It shows that resistance change ( R / 0 ) 100% strain about 5.6 times, which much lower than other exhibits ≈200%. Simultaneously, this an encapsulation‐free avoids performance degradation caused by encapsulation. Furthermore, it found adhesion strength metal substrate critical stability so polydimethylsiloxane 0.9 ‐isophorone diisocyanate elastomer (PDMS ‐IPDI), whose 4.5 times higher commercial (PDMS), synthesized. Finally, electrophysiological communication different organisms successfully demonstrated.

Language: Английский

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In Vivo Chronic Brain Cortex Signal Recording Based on a Soft Conductive Hydrogel Biointerface

ACS Applied Materials & Interfaces, Journal Year: 2022, Volume and Issue: 15(5), P. 6283 - 6296

Published: Dec. 28, 2022

In neuroscience, the acquisition of neural signals from brain cortex is crucial to analyze processes, detect neurological disorders, and offer therapeutic brain-computer interfaces. The design interfaces conformable tissue one today's major challenges since insufficient biocompatibility those systems provokes a fibrotic encapsulation response, leading an inaccurate signal recording damage precluding long-term/permanent implants. production novel soft biointerface made polyacrylamide hydrogels loaded with plasmonic silver nanocubes are reported herein. Hydrogels surrounded by silicon-based template as supporting element for guaranteeing intimate neural-hydrogel contact while making possible stable recordings specific sites in cortex. nanostructured show superior electroconductivity mimicking mechanical characteristics tissue. Furthermore, vitro biological tests performed culturing progenitor cells demonstrate along neuronal differentiation. vivo chronic neuroinflammation on mouse model no adverse immune response toward hydrogel-based interface. Additionally, electrocorticography acquisitions indicate that proposed platform permits long-term efficient signals, revealing suitability system biointerface.

Language: Английский

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Liquid metal–hydrogel composites for flexible electronics

Chemical Communications, Journal Year: 2023, Volume and Issue: 59(97), P. 14353 - 14369

Published: Jan. 1, 2023

As an emerging functional material, liquid metal–hydrogel composites exhibit excellent biosafety, high electrical conductivity, tunable mechanical properties etc., providing a unique platform for wide range of flexible electronics applications.

Language: Английский

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