Freeze-resistant, rapidly polymerizable, ionic conductive hydrogel induced by Deep Eutectic Solvent (DES) after lignocellulose pretreatment for flexible sensors

International Journal of Biological Macromolecules, Journal Year: 2022, Volume and Issue: 224, P. 143 - 155

Published: Oct. 17, 2022

Language: Английский

---

Poloxamer-Based Hydrogel as Drug Delivery System: How Polymeric Excipients Influence the Chemical-Physical Properties

Polymers, Journal Year: 2022, Volume and Issue: 14(17), P. 3624 - 3624

Published: Sept. 1, 2022

Thermogelling amphiphilic block copolymers have been widely investigated in the development of pharmaceutical drug carriers. In particular, thermosensitive gels based on poloxamer 407 (P407) great potential for periodontal disease treatment, thanks to their ability be liquid at room temperature and become viscous body temperature. However, some problems, related short situ residence time, reduce feasible clinical use. Thus, order improve effective applicability these materials, we studied how P407 thermogels are affected by pH inclusion different hydrophilic polymers, used as excipients increasing gel stiffness. For this scope, a complete chemical-physical characterization synthesized is provided, terms determination sol-gel transition temperature, viscosity erosion degree. The data correlated according statistical multivariate approach Principal Component Analysis mucoadhesion properties also tested Tapping mode-Atomic Force Microscopy (TM-AFM) imaging. Finally, formulations able influence release pathway two antibacterial drugs (i.e., chlorhexidine digluconate doxycycline hyclate) largely oral diseases.

Language: Английский

---

Anti‐Dehydration and Rapid Trigger‐Detachable Multifunctional Hydrogels Promote Scarless Therapeutics of Deep Burn

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(17)

Published: Feb. 1, 2023

Abstract There are issues and challenges in treating deep burns because of the long recovery time, frequent dressing changes, wound infection, easy to form scar that influence aesthetics. Besides, some specific tissues not suitable for large coverage (e.g., face, perineum). Therefore, an ideal burn should have good adhesion properties fit effectively, painless quick replacement, resistant accelerate healing, reduce scarring facilitate monitoring diagnosis. Herein, anti‐dehydration rapid‐trigger multifunctional hydrogel is prepared by interface reaction. The Pacrylamide‐Formylboronicacid‐Tannic acid (PAFT) hydrogels a simple method on elastomeric membrane, which obtained using tannic as dynamic cross‐linking agent with 3‐formylboronic acrylamideunder UV light. exhibits strong interfacial (892 J m −2 ± 65 ), rapidly (2 min) decreases (to 180 20 ) when presence glucose solution. has excellent moisturizing properties, also superior antibacterial hemostasis, biocompatibility. This transparent allowing effective observation transformation therapeutics. Moreover, PAFT accelerates healing reduces scars.

Language: Английский

---

Bioadhesives with Antimicrobial Properties

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(49)

Published: June 3, 2023

Bioadhesives with antimicrobial properties enable easier and safer treatment of wounds as compared to the traditional methods such suturing stapling. Composed natural or synthetic polymers, these bioadhesives seal facilitate healing while preventing infections through activity locally released drugs, nanocomponents, inherently polers. Although many different materials strategies are employed develop bioadhesives, design biomaterials necessitates a prudent approach achieving all required including optimal adhesive cohesive properties, biocompatibility, can be challenging. Designing tunable physical, chemical, biological will shed light on path for future advancement properties. In this review, requirements commonly used developing discussed. particular, their synthesis experimental clinical applications variety organs reviewed. Advances in pave way better management increase positive outcomes.

Language: Английский

---

Self-healing hydrogels based on biological macromolecules in wound healing: A review

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 253, P. 127612 - 127612

Published: Oct. 21, 2023

Language: Английский

---