Journal of Applied Polymer Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 29, 2025
ABSTRACT
While
various
biomedical
sealants
exist,
many
suffer
from
several
drawbacks.
For
example,
hydrogels
with
superior
sealing
properties
often
exhibit
limitations
such
as
conflict‐free,
individual,
and
flexible
control
over
injectability
gel
physical
properties,
well
regarding
applications
in
diverse
scenarios.
This
article
presents
PL/OHA,
a
pH‐driven
injectable
hydrogel
sealant
designed
for
wound
sealing.
PL/OHA
employs
dynamic
bonds,
including
Schiff
base
hydrogen
to
produce
biodegradable
biocompatible
sealant.
By
individually
adjusting
the
pH
value
solid
content,
gelation
time,
mechanical
adhesion
strength
of
can
be
flexibly
controlled
meet
different
requirements
wound‐sealing
contexts.
Experiments
prove
that
injection
time
controlled,
seconds
tens
minutes,
by
changing
value.
It
also
exhibits
adjustable
properties.
When
content
is
increased
24%
36%,
tensile
increases
10.12
25.12
kPa,
compressive
97.50
516.61
kPa.
remarkable
antibacterial
activity,
healing
promotion
capacity,
excellent
biocompatibility.
These
make
it
promising
candidate
future
clinical
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(15)
Published: Feb. 2, 2024
Abstract
Hypoxia
and
infection
are
urgent
clinical
problems
in
chronic
diabetic
wounds.
Herein,
living
Chlorella
‐loaded
poly(ionic
liquid)‐based
microneedles
(PILMN‐Chl)
constructed
for
microacupuncture
oxygen
antibacterial
therapy
against
methicillin‐resistant
Staphylococcus
aureus
(MRSA)‐infected
The
PILMN‐Chl
can
stably
continuously
produce
more
than
30
h
due
to
the
photosynthesis
of
loaded
self‐supported
.
By
combining
barrier
penetration
capabilities
microneedles,
continuous
sufficient
supply
,
sterilization
activities
PIL,
accelerate
wounds
vivo
by
topical
targeted
hypoxia
relief
deep
parts
Thus,
self‐oxygen
produced
modality
may
provide
a
promising
facile
therapeutic
strategy
treating
chronic,
hypoxic,
infected
ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(31), P. 33303 - 33334
Published: July 25, 2024
The
increasing
occurrence
of
infectious
diseases
caused
by
antimicrobial
resistance
organisms
urged
the
necessity
to
develop
more
potent,
selective,
and
safe
agents.
unique
magnetic
tunable
properties
iron
oxide
nanoparticles
(IONPs)
make
them
a
promising
candidate
for
different
theragnostic
applications,
including
Though
IONPs
act
as
nonspecific
agent,
their
activities
are
directly
or
indirectly
linked
with
synthesis
methods,
synthesizing
precursors,
size,
shapes,
concentration,
surface
modifications.
Alteration
these
parameters
could
accelerate
decelerate
production
reactive
oxygen
species
(ROS).
An
increase
in
ROS
role
disrupts
bacterial
cell
walls,
membranes,
alters
major
biomolecules
(e.g.,
lipids,
proteins,
nucleic
acids),
affects
metabolic
processes
Krebs
cycle,
fatty
acid
synthesis,
ATP
glycolysis,
mitophagy).
In
this
review,
we
will
investigate
antibacterial
activity
bare
surface-modified
influence
physiochemical
on
activity.
Additionally,
report
potential
mechanism
IONPs'
action
driving
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(45)
Published: Oct. 11, 2024
Abstract
Oral
ulcers
can
be
addressed
using
various
biomaterials
designed
to
deliver
medications
or
cytokines.
Nevertheless,
the
effectiveness
of
these
substances
is
frequently
limited
in
many
patients
due
poor
adherence,
short
retention
time
mouth,
and
less‐than‐optimal
drug
efficacy.
In
this
study,
a
new
hydrogel
patch
(FSH3)
made
silk
fibroin/hyaluronic
acid
matrix
with
light‐sensitive
adhesive
qualities
infused
ferric
iron/shikonin
nanoparticles
enhance
healing
effects
presented.
Initially,
forms
an
barrier
over
mucosal
lesions
through
straightforward
local
injection,
solidifying
when
exposed
UV
light.
Subsequently,
FSH3
demonstrates
superior
reactive
oxygen
species
elimination
near‐infrared
photothermal
bactericidal
activity.
These
characteristics
support
bacterial
regulate
oxidative
levels,
promoting
wound's
progression
from
inflammation
tissue
regeneration.
diabetic
rat
model
mimicking
oral
ulcers,
significantly
speeds
up
by
adjusting
inflammatory
environment
injured
tissue,
maintaining
balance
microbiota,
faster
re‐epithelialization.
Overall,
shows
potential
for
rapid
wound
recovery
may
transform
therapeutic
methods
managing
diabetes.
Chemical Engineering Journal,
Journal Year:
2024,
Volume and Issue:
481, P. 148674 - 148674
Published: Jan. 11, 2024
Multi-resistant
pathogens
can
cause
several
nosocomial
infections
that
harm
hospital
interventions
or
undermine
biological
processes.
In
this
scenario,
the
development
of
novel
and
efficient
antimicrobial
materials
is
essential
to
reducing
pathogen
spread.
Though
many
approaches
have
been
followed
with
aim,
scalability,
safety,
efficiency
concerns
still
hamper
their
clinical
transfer.
work,
we
overcome
these
limitations
by
co-polymerizing
phenolic
derivatives
amino-terminal
ligands.
The
resulting
coatings
are
successfully
applied
woven
non-woven-based
used
in
healthcare:
paper,
cotton
polypropylene.
Moreover,
demonstrate
multi-pathway
activity
against
six
bacteria
(E.
coli,
P.
aeruginosa,
S.
aureus,
methicillin-resistant
E.
faecalis,
B.
subtilis)
two
fungi
(C.
albicans
C.
auris),
a
fact
attributed
i)
reactive
oxygen
species
generation
over
time
ii)
protic
amino
groups
exposed
on
surface.
After
180
min,
viable
reduced
more
than
99.9
%,
comparable
decline
after
24
h.
As
proof-of-concept,
coated
commercial
band-aids
tested
skin
ex
vivo
bacterial
growth
about
90
%.
Considering
results
long-lasting,
vitro
biocompatibility,
scalability
eco-friendly
technology,
represent
promising
alternative
be
healthcare
environments,
avoiding
spread,
resistance.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(41)
Published: Aug. 19, 2024
Abstract
With
the
rapid
emergence
of
antibiotic‐resistant
pathogens,
nanomaterial‐assisted
catalytic
sterilization
has
been
well
developed
to
combat
pathogenic
bacteria
by
elevating
level
reactive
oxygen
species
including
hydroxyl
radical
(·OH).
Although
promising,
ultra‐short
lifetime
and
limited
diffusion
distance
·OH
severely
limit
their
practical
antibacterial
usage.
Herein,
rational
design
preparation
novel
virus‐like
copper
silicate
hollow
spheres
(CSHSs)
are
reported,
as
applications
robust
artificial
bacteriophages
for
localized
bacterial
capture
enhanced
in
treatment
oral
infectious
diseases.
During
whole
process
killing,
CSHSs
can
efficiently
via
shortening
between
CSHSs,
produce
massive
around
bacteria,
further
iinducing
admirable
effect
inhibition.
By
using
mucosal
infection
periodontitis
typical
diseases,
it
is
easily
found
that
populations
lesions
animals
after
fall
sharply,
well‐developed
nanosystem
decrease
inflammatory
reaction
promote
hard
or
soft
tissue
repair.
Together,
high
Fenton‐like
activity,
strong
affinity,
excellent
overall
safety
nanoplatform
promise
its
great
therapeutic
potential
disinfection.
International Journal of Nanomedicine,
Journal Year:
2023,
Volume and Issue:
Volume 18, P. 6425 - 6448
Published: Nov. 1, 2023
Abstract:
Chronic
wounds
are
recalcitrant
complications
of
a
variety
diseases,
with
pathologic
features
including
bacterial
infection,
persistent
inflammation,
and
proliferation
reactive
oxygen
species
(ROS)
levels
in
the
wound
microenvironment.
Currently,
use
antimicrobial
drugs,
debridement,
hyperbaric
therapy,
other
methods
clinical
for
chronic
treatment
is
prone
to
problems
such
as
resistance,
expansion,
even
exacerbation.
In
recent
years,
researchers
have
proposed
many
novel
materials
targeting
disease
characteristics,
among
which
metal–phenolic
networks
(MPNs)
supramolecular
network
structures
that
utilize
multivalent
metal
ions
natural
polyphenols
complexed
through
ligand
bonds.
They
flexible
versatile
combination
structural
forms
formations
(nanoparticles,
coatings,
hydrogels,
etc.)
can
be
constructed.
Functionally,
MPNs
combine
chemocatalytic
bactericidal
properties
well
anti-inflammatory
antioxidant
polyphenol
compounds.
Together
excellent
rapid
synthesis
negligible
cytotoxicity,
attracted
researchers'
great
attention
biomedical
fields
anti-tumor,
anti-bacterial,
anti-inflammatory.
This
paper
will
focus
on
composition
MPNs,
mechanisms
wounds,
application
therapies.
Keywords:
networks,
antimicrobial,
antioxidant,
scavenging,
revascularization
Biomaterials Science,
Journal Year:
2024,
Volume and Issue:
12(9), P. 2282 - 2291
Published: Jan. 1, 2024
Polyphenolic
antibacterial
bio-adhesives
were
synthesised
via
polyphenols
and
acid
anhydrides
without
solvent
or
catalyst.
Upon
heating,
these
adhesives
could
induce
strong
adhesion
onto
various
substrates,
while
demonstrating
excellent
antibacterial,
antiinfection
biodegradability
properties.
