Progress in Organic Coatings, Journal Year: 2024, Volume and Issue: 197, P. 108748 - 108748
Published: Aug. 31, 2024
Language: Английский
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(15)
Published: Feb. 2, 2024
Abstract Hypoxia and infection are urgent clinical problems in chronic diabetic wounds. Herein, living Chlorella ‐loaded poly(ionic liquid)‐based microneedles (PILMN‐Chl) constructed for microacupuncture oxygen antibacterial therapy against methicillin‐resistant Staphylococcus aureus (MRSA)‐infected The PILMN‐Chl can stably continuously produce more than 30 h due to the photosynthesis of loaded self‐supported . By combining barrier penetration capabilities microneedles, continuous sufficient supply , sterilization activities PIL, accelerate wounds vivo by topical targeted hypoxia relief deep parts Thus, self‐oxygen produced modality may provide a promising facile therapeutic strategy treating chronic, hypoxic, infected
Language: Английский
Citations
44
ACS Omega, Journal Year: 2024, Volume and Issue: 9(31), P. 33303 - 33334
Published: July 25, 2024
The increasing occurrence of infectious diseases caused by antimicrobial resistance organisms urged the necessity to develop more potent, selective, and safe agents. unique magnetic tunable properties iron oxide nanoparticles (IONPs) make them a promising candidate for different theragnostic applications, including Though IONPs act as nonspecific agent, their activities are directly or indirectly linked with synthesis methods, synthesizing precursors, size, shapes, concentration, surface modifications. Alteration these parameters could accelerate decelerate production reactive oxygen species (ROS). An increase in ROS role disrupts bacterial cell walls, membranes, alters major biomolecules (e.g., lipids, proteins, nucleic acids), affects metabolic processes Krebs cycle, fatty acid synthesis, ATP glycolysis, mitophagy). In this review, we will investigate antibacterial activity bare surface-modified influence physiochemical on activity. Additionally, report potential mechanism IONPs' action driving
Language: Английский
Citations
16
Advances in Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 339, P. 103425 - 103425
Published: Feb. 15, 2025
Language: Английский
Citations
3
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 481, P. 148674 - 148674
Published: Jan. 11, 2024
Multi-resistant pathogens can cause several nosocomial infections that harm hospital interventions or undermine biological processes. In this scenario, the development of novel and efficient antimicrobial materials is essential to reducing pathogen spread. Though many approaches have been followed with aim, scalability, safety, efficiency concerns still hamper their clinical transfer. work, we overcome these limitations by co-polymerizing phenolic derivatives amino-terminal ligands. The resulting coatings are successfully applied woven non-woven-based used in healthcare: paper, cotton polypropylene. Moreover, demonstrate multi-pathway activity against six bacteria (E. coli, P. aeruginosa, S. aureus, methicillin-resistant E. faecalis, B. subtilis) two fungi (C. albicans C. auris), a fact attributed i) reactive oxygen species generation over time ii) protic amino groups exposed on surface. After 180 min, viable reduced more than 99.9 %, comparable decline after 24 h. As proof-of-concept, coated commercial band-aids tested skin ex vivo bacterial growth about 90 %. Considering results long-lasting, vitro biocompatibility, scalability eco-friendly technology, represent promising alternative be healthcare environments, avoiding spread, resistance.
Language: Английский
Citations
14
Advanced Science, Journal Year: 2024, Volume and Issue: 11(45)
Published: Oct. 11, 2024
Abstract Oral ulcers can be addressed using various biomaterials designed to deliver medications or cytokines. Nevertheless, the effectiveness of these substances is frequently limited in many patients due poor adherence, short retention time mouth, and less‐than‐optimal drug efficacy. In this study, a new hydrogel patch (FSH3) made silk fibroin/hyaluronic acid matrix with light‐sensitive adhesive qualities infused ferric iron/shikonin nanoparticles enhance healing effects presented. Initially, forms an barrier over mucosal lesions through straightforward local injection, solidifying when exposed UV light. Subsequently, FSH3 demonstrates superior reactive oxygen species elimination near‐infrared photothermal bactericidal activity. These characteristics support bacterial regulate oxidative levels, promoting wound's progression from inflammation tissue regeneration. diabetic rat model mimicking oral ulcers, significantly speeds up by adjusting inflammatory environment injured tissue, maintaining balance microbiota, faster re‐epithelialization. Overall, shows potential for rapid wound recovery may transform therapeutic methods managing diabetes.
Language: Английский
Citations
12
International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 6425 - 6448
Published: Nov. 1, 2023
Abstract: Chronic wounds are recalcitrant complications of a variety diseases, with pathologic features including bacterial infection, persistent inflammation, and proliferation reactive oxygen species (ROS) levels in the wound microenvironment. Currently, use antimicrobial drugs, debridement, hyperbaric therapy, other methods clinical for chronic treatment is prone to problems such as resistance, expansion, even exacerbation. In recent years, researchers have proposed many novel materials targeting disease characteristics, among which metal–phenolic networks (MPNs) supramolecular network structures that utilize multivalent metal ions natural polyphenols complexed through ligand bonds. They flexible versatile combination structural forms formations (nanoparticles, coatings, hydrogels, etc.) can be constructed. Functionally, MPNs combine chemocatalytic bactericidal properties well anti-inflammatory antioxidant polyphenol compounds. Together excellent rapid synthesis negligible cytotoxicity, attracted researchers' great attention biomedical fields anti-tumor, anti-bacterial, anti-inflammatory. This paper will focus on composition MPNs, mechanisms wounds, application therapies. Keywords: networks, antimicrobial, antioxidant, scavenging, revascularization
Language: Английский
Citations
17
Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(9), P. 2282 - 2291
Published: Jan. 1, 2024
Polyphenolic antibacterial bio-adhesives were synthesised via polyphenols and acid anhydrides without solvent or catalyst. Upon heating, these adhesives could induce strong adhesion onto various substrates, while demonstrating excellent antibacterial, antiinfection biodegradability properties.
Language: Английский
Citations
8
Advanced Science, Journal Year: 2024, Volume and Issue: 11(41)
Published: Aug. 19, 2024
Abstract With the rapid emergence of antibiotic‐resistant pathogens, nanomaterial‐assisted catalytic sterilization has been well developed to combat pathogenic bacteria by elevating level reactive oxygen species including hydroxyl radical (·OH). Although promising, ultra‐short lifetime and limited diffusion distance ·OH severely limit their practical antibacterial usage. Herein, rational design preparation novel virus‐like copper silicate hollow spheres (CSHSs) are reported, as applications robust artificial bacteriophages for localized bacterial capture enhanced in treatment oral infectious diseases. During whole process killing, CSHSs can efficiently via shortening between CSHSs, produce massive around bacteria, further iinducing admirable effect inhibition. By using mucosal infection periodontitis typical diseases, it is easily found that populations lesions animals after fall sharply, well‐developed nanosystem decrease inflammatory reaction promote hard or soft tissue repair. Together, high Fenton‐like activity, strong affinity, excellent overall safety nanoplatform promise its great therapeutic potential disinfection.
Language: Английский
Citations
8
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 489, P. 151499 - 151499
Published: April 21, 2024
Language: Английский
Citations
6
Cellulose, Journal Year: 2023, Volume and Issue: 31(1), P. 703 - 715
Published: Dec. 6, 2023
Language: Английский
Citations
14