New Journal of Chemistry, Journal Year: 2022, Volume and Issue: 46(27), P. 12901 - 12904
Published: Jan. 1, 2022
A metal- and base-free regioselective cascade sulfonylation–cyclization reaction of linear substrates, 1,5-dienes, has been developed to synthesize sulfonylated pyrrolinones.
Language: Английский
Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(6), P. 2313 - 2382
Published: Jan. 1, 2022
Visible-light photoredox catalysis has been regarded as an extremely powerful tool in organic chemistry, bringing the spotlight back to radical processes. The versatility of photocatalyzed reactions already demonstrated be effective providing alternative routes for cross-coupling well multicomponent reactions. photocatalyst allows generation high-energy intermediates through light irradiation rather than using highly reactive reagents or harsh reaction conditions. In a similar vein, electrochemistry experienced fruitful renaissance generating without need any catalyst. Such milder approaches pose basis toward higher selectivity and broader applicability. electrochemical reactions, species acts starter cascade events. This diverse reactivity use is usually not covered by classical methods. Owing availability cheaper more standardized photo- reactors, easily scalable flow-setups, it surprising that these two fields have become areas increased research interest. Keeping view, this review aimed at overview synthetic design MCRs involving and/or activation crucial step with particular focus on choice difunctionalized reagent.
Language: Английский
Citations
163
Chem Catalysis, Journal Year: 2024, Volume and Issue: 4(5), P. 100945 - 100945
Published: March 5, 2024
Language: Английский
Citations
14
Organic Chemistry Frontiers, Journal Year: 2022, Volume and Issue: 9(7), P. 1937 - 1942
Published: Jan. 1, 2022
An iron-catalyzed dearomative spirocyclization of biaryl ynones with sodium metabisulfite and cycloketone oxime esters is developed for the construction sulfonated spiro[5,5]trienones.
Language: Английский
Citations
29
The Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 88(6), P. 3772 - 3780
Published: March 6, 2023
A novel multicomponent sulfonylation of alkenes is described for the assembly various β-substituted arylsulfones using cheap and easily available K2S2O5 as a sulfur dioxide source. Of note, procedure does not need any extra oxidants metal catalysts exhibits relatively wide substrate scope good functional group compatibility. Mechanistically, an initial arylsulfonyl radical formed involving insertion with aryl diazonium salt, followed by alkoxyarylsulfonylation or hydroxysulfonylation alkenes.
Language: Английский
Citations
17
Organic Chemistry Frontiers, Journal Year: 2022, Volume and Issue: 9(17), P. 4757 - 4781
Published: Jan. 1, 2022
Radical strategies for preparation of seven- or eight-membered rings.
Language: Английский
Citations
26
Organic Letters, Journal Year: 2022, Volume and Issue: 24(31), P. 5791 - 5796
Published: Aug. 2, 2022
A novel visible-light-mediated difluoroalkylation of 1-(allyloxy)-2-(1-arylvinyl)benzenes and 1-(1-arylvinyl)-2-(vinyloxy)benzenes for the synthesis bis-difluoroalkylated benzoxepines 2H-chromenes is developed. This method features mild reaction conditions, good regioselectivity, a wide substrate scope, functional-group compatibility, late-stage modification. Preliminary mechanistic studies reveal that generation CF2CO2Et radical more prone to with double bond aryl group.
Language: Английский
Citations
20
The Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 88(4), P. 2057 - 2068
Published: Jan. 30, 2023
This study describes a visible-light-induced cascade reaction for preparing cyanoalkyl-containing polyheterocycles initiated by the photoinduced radical addition of N-arylacrylamide derivatives using cyclic oxime esters as sources followed cyanoalkyl-mediated cyclization. protocol features outstanding functional group compatibility, providing variety desired phenanthridine in moderate to good yields. Moreover, application microflow technique enhanced these reactions compared with equivalent batch reaction, significantly reducing times 10 min.
Language: Английский
Citations
13
Organic Letters, Journal Year: 2023, Volume and Issue: 25(32), P. 6072 - 6076
Published: Aug. 8, 2023
A novel and efficient strategy for the synthesis of a series structurally interesting benzazepine derivatives via an N-heterocyclic carbene-catalyzed regioselective intramolecular radical cyclization has been developed. This protocol features good regioselectivity, functional-group compatibility, wide substrate scope, providing transition-metal- oxidant-free pathway to access seven-membered rings under mild reaction conditions. Additionally, further transformation benzazepines large-scale experiment were also conducted.
Language: Английский
Citations
12
Chemical Communications, Journal Year: 2022, Volume and Issue: 58(14), P. 2335 - 2338
Published: Jan. 1, 2022
A palladium-catalyzed radical cascade cyanoalkylsulfonylation/cyclization of 3-arylethynyl-[1,1'-biphenyl]-2-carbonitriles with DABCO·(SO2)2 and cyclobutanone oxime esters via cleavage a C-C single bond insertion SO2 was described. series cyanoalkylsulfone-containing cyclopenta[gh]phenanthridines were obtained in moderate-to-good yields, thus featuring mild reaction conditions, broad substrate scope, high functional group tolerance.
Language: Английский
Citations
17
Tetrahedron, Journal Year: 2025, Volume and Issue: unknown, P. 134620 - 134620
Published: March 1, 2025
Language: Английский
Citations
0