Lipid droplet‐targeted NIR AIE photosensitizer evoking concurrent ferroptosis and apoptosis

Aggregate, Journal Year: 2024, Volume and Issue: 5(3)

Published: Feb. 1, 2024

Abstract Lipid droplets (LDs), which are the hubs of lipid metabolism, play a critical role in maintaining cellular energy homeostasis. The construction advanced photosensitizers (PSs) capable manipulating LD‐mediated cell fate regulation is highly desirable though rarely reported. In this study, near‐infrared emissive PS (DPCMP) with LDs specificity was synthesized and successfully applied to induce ferroptosis apoptosis. DPCMP exhibited typical aggregation‐induced emission characteristics owing its twisted molecular conformation. Excellent biocompatibility suitable lipophilicity allowed specifically stain living cells. Under white light illumination, displayed potent reactive oxygen species (ROS) generation capacity through both type I II photochemistry. massive accumulation lethal ROS generated by DPCMP‐mediated photosensitization initiated peroxidation, impaired redox homeostasis, led endoplasmic reticulum oxidative stress, ultimately inhibiting proliferation via concurrent apoptosis cancer cells multicellular tumor spheroids.

Language: Английский

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Functional probes for the diagnosis and treatment of infectious diseases

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: June 25, 2024

Abstract Infectious diseases present significant challenges to global health, thereby extensively affecting both human society and the economy. In recent years, functional probes have demonstrated remarkable potential as crucial biomedical media for research treatment of infectious diseases. Their applications in realm include pathogen detection, exploration biological mechanisms, development anti‐infective drugs. This review provides a concise introduction severity, classification, pathogenesis Subsequently, we examined distinctiveness design strategies diagnosing treating diseases, shedding light on their rationale using typical examples. We discuss current status associated with clinical implementation probes. Furthermore, explored prospects these diagnosis aims offer novel insights into diagnostic broaden disease treatment.

Language: Английский

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Extensive optical and DFT studies on novel AIE active fluorescent sensor for Colorimetric and fluorometric detection of nitrobenzene in Solid, solution and vapor phase

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2024, Volume and Issue: 313, P. 124121 - 124121

Published: March 6, 2024

Language: Английский

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Recent advances in biomimetic aggregation‐induced emission photosensitizers for photodynamic therapy and immunotherapy

BMEMat, Journal Year: 2024, Volume and Issue: 2(3)

Published: April 24, 2024

Abstract The development of novel photosensitizers (PSs) with aggregation‐induced emission (AIE) properties has emerged as a crucial advancement in the field photodynamic therapy (PDT). However, versatile applications AIE PSs are limited by low encapsulation efficiency and inadequate target tissue permeability. Biomimetic technology stands out promising strategy to overcome these challenges, aiming enhance tumor penetration efficacy, their association antitumor immune responses. In this review, recent advancements biomimetic for PDT immunotherapy summarized. We start introducing strategies involving based on cell membranes extracellular vesicles combined application immunotherapy. then discuss preparation nanoparticles. Finally, we briefly outline challenges prospects associated PSs.

Language: Английский

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Amphiphilic quinoline-malononitrile AIE probes: From molecule design to bio-applications

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 533, P. 216550 - 216550

Published: Feb. 24, 2025

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