Bulky N-heterocyclic carbene Cu(I) complex as a catalyst for the synthesis of N-arylazoles under ambient conditions DOI
Guiyan Liu, Qi Ding, Jiayi Chen

et al.

Tetrahedron, Journal Year: 2025, Volume and Issue: 172, P. 134449 - 134449

Published: Jan. 5, 2025

Language: Английский

Mechanochemistry in Senior Undergraduate Laboratory: NHC Complexes, Catalysis, and Sonogashira Cross-Coupling DOI Creative Commons
Abeer F. Shunnar,

R. Srinivasa Rao,

Mohamed Aslam

et al.

Journal of Chemical Education, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Language: Английский

Citations

0
Tunable Unsymmetrical Ferrocene Ligands Bearing a Bulky Di-1-adamantylphosphino Motif for Many Kinds of Csp2–Csp3 Couplings DOI
Guolin Xu,

Peng Gao,

Thomas J. Colacot

et al.

ACS Catalysis, Journal Year: 2022, Volume and Issue: 12(9), P. 5123 - 5135

Published: April 15, 2022

A class of ferrocene-based unsymmetrical bidentate ligands containing a di(1-adamantyl)phosphino group, Fc(PAd2)(PR2) (R = Ph, Cy, iPr, tBu) abbreviated as MPhos ligands, and their corresponding (MPhos)PdCl2 pre-catalysts were synthesized in very good yields fully characterized using techniques including single-crystal X-ray crystallography. These utilized for Csp2–Csp3 couplings many kinds name reactions such Murahashi–Feringa, Kumada–Corriu, Negishi, Suzuki–Miyaura with substrate scope isolated yields. About nine "drug-like" molecules also tested successfully to demonstrate potential applications active pharmaceutical ingredient (API) synthesis. The tunability the catalyst system enabled matching sterics electronics ligand that substrates have desirable results over five dozen systems selectivity.

Language: Английский

Citations

18
Suzuki–Miyaura Cross-Coupling of 2-Pyridyl Trimethylammonium Salts by N–C Activation Catalyzed by Air- and Moisture-Stable Pd–NHC Precatalysts: Application to the Discovery of Agrochemicals DOI

Yuge Hu,

Yanqing Gao,

Jiuhui Ye

et al.

Organic Letters, Journal Year: 2023, Volume and Issue: 25(17), P. 2975 - 2980

Published: April 20, 2023

We report the first Suzuki-Miyaura cross-coupling of 2-pyridyl ammonium salts by highly selective N-C activation catalyzed air- and moisture-stable Pd(II)-NHC (NHC = N-heterocyclic carbene) precatalysts. The use well-defined reactive [Pd(IPr)(3-CF3-An)Cl2] (An aniline) or [Pd(IPr)(cin)Cl] (cin cinnamyl) catalysts permits an exceptionally broad scope to furnish valuable biaryl heterobiarylpyridines that are ubiquitous in medicinal chemistry agrochemistry research. overall process leverages Chichibabin C-H amination pyridines with enable attractive strategy problem. utility method discovery potent agrochemicals is presented. Considering importance 2-pyridines versatility methods, we envision this new C-H/N-C will find application.

Language: Английский

Citations

10
Propargyl Amines by Aldehyde-Amine-Acetylene Coupling Mediated by Ag(I) and Cu(I) Complexes of Super Bulky N-Heterocyclic Carbenes: Unveiling the Role of the Super Bulky Ligands in the Coupling Reaction DOI
Rajesh Manne,

Sunita Sharma,

Shreyata Dey

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1316, P. 139022 - 139022

Published: June 15, 2024

Language: Английский

Citations

3
Bulky N-heterocyclic carbene Cu(I) complex as a catalyst for the synthesis of N-arylazoles under ambient conditions DOI
Guiyan Liu, Qi Ding, Jiayi Chen

et al.

Tetrahedron, Journal Year: 2025, Volume and Issue: 172, P. 134449 - 134449

Published: Jan. 5, 2025

Language: Английский

Citations

0