Recent Developments in Bio-Ink Formulations Using Marine-Derived Biomaterials for Three-Dimensional (3D) Bioprinting

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(3), P. 134 - 134

Published: March 16, 2024

3D bioprinting is a disruptive, computer-aided, and additive manufacturing technology that allows the obtention, layer-by-layer, of complex structures. This believed to offer tremendous opportunities in several fields including biomedical, pharmaceutical, food industries. Several processes bio-ink materials have emerged recently. However, there still pressing need develop low-cost sustainable with superior qualities (excellent mechanical, viscoelastic thermal properties, biocompatibility, biodegradability). Marine-derived biomaterials, polysaccharides proteins, represent viable renewable source for formulations. Therefore, focus this review centers around use marine-derived biomaterials formulations bio-ink. It starts general overview followed by description most commonly used bioprinting, special attention paid chitosan, glycosaminoglycans, alginate, carrageenan, collagen, gelatin. The challenges facing application within biomedical pharmaceutical along future directions are also discussed.

Language: Английский

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Applications of Polymers for Organ-on-Chip Technology in Urology

Polymers, Journal Year: 2022, Volume and Issue: 14(9), P. 1668 - 1668

Published: April 20, 2022

Organ-on-chips (OOCs) are microfluidic devices used for creating physiological organ biomimetic systems. OOC technology brings numerous advantages in the current landscape of preclinical models, capable recapitulating multicellular assemblage, tissue-tissue interaction, and replicating human pathologies. Moreover, cancer research, OOCs emulate 3D hierarchical complexity vivo tumors mimic tumor microenvironment, being a practical cost-efficient solution tumor-growth investigation anticancer drug screening. compact easy-to-use microphysiological functional units that recapitulate native function mechanical strain cells experience bodies, allowing development wide range applications such as disease modeling or even diagnostic devices. In this context, work aims to review scientific literature field designed urology terms fabrication (principles manufacture materials used), kidney-on-chip models drug-toxicity screening kidney modeling, bladder-on-chip urinary tract infections bladder prostate-on-chip prostate modeling.

Language: Английский

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Silk-Based Biomaterials for Designing Bioinspired Microarchitecture for Various Biomedical Applications

Biomimetics, Journal Year: 2023, Volume and Issue: 8(1), P. 55 - 55

Published: Jan. 28, 2023

Biomaterial research has led to revolutionary healthcare advances. Natural biological macromolecules can impact high-performance, multipurpose materials. This prompted the quest for affordable solutions, with a focus on renewable biomaterials wide variety of applications and ecologically friendly techniques. Imitating their chemical compositions hierarchical structures, bioinspired based materials have elevated rapidly over past few decades. Bio-inspired strategies entail extracting fundamental components reassembling them into programmable biomaterials. method may improve its processability modifiability, allowing it meet application criteria. Silk is desirable biosourced raw material due high mechanical properties, flexibility, bioactive component sequestration, controlled biodegradability, remarkable biocompatibility, inexpensiveness. regulates temporo-spatial, biochemical biophysical reactions. Extracellular factors regulate cellular destiny dynamically. review examines structural functional properties silk scaffolds. We explored types, composition, architecture, topography, 3D geometry unlock body’s innate regenerative potential, keeping in mind novel film, fiber, other potential forms, coupled facile changes, ability match requirements specific tissues.

Language: Английский

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Recent advances in biofabrication strategies based on bioprinting for vascularized tissue repair and regeneration

Materials & Design, Journal Year: 2023, Volume and Issue: 229, P. 111885 - 111885

Published: March 31, 2023

Vascularization plays a crucial role in transporting and exchanging nutrients oxygen between implanted grafts with the host tissue. In biofabrication of grafts, remodeling vascular networks can accelerate vascularized tissue repair regeneration. Given heterogeneity tissues, traditional scaffold manufacturing techniques cannot effectively achieve various scales vitro vivo biomimetic. recent years, 3D bioprinting technologies have been widely used fabricating for regeneration due to their shape customizability, simple procedure, reproducibility, precise multi-dimensional control. With rapid development technologies, bioprinting-based strategies gradually applied construction tissues. Based on this background, our study aimed review advances, challenges, future perspectives based The techniques, bioinks, seed cells, growth factors were also enrolled review. addition, history, vessel formation mechanism, histology discussed.

Language: Английский

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The Material World of 3D‐Bioprinted and Microfluidic‐Chip Models of Human Liver Fibrosis

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(2)

Published: Nov. 14, 2023

Biomaterials are extensively used to mimic cell-matrix interactions, which essential for cell growth, function, and differentiation. This is particularly relevant when developing in vitro disease models of organs rich extracellular matrix, like the liver. Liver involves a chronic wound-healing response with formation scar tissue known as fibrosis. At early stages, liver can be reverted, but progresses, reversion no longer possible, there cure. Research new therapies hampered by lack adequate that replicate mechanical properties biochemical stimuli present fibrotic Fibrosis associated changes composition matrix directly influence behavior. could play an role better emulating microenvironment. In this paper, recent cutting-edge biomaterials creating human fibrosis revised, combination cells, bioprinting, and/or microfluidics. These technologies have been instrumental intricate structure unhealthy promote medium perfusion improves growth respectively. A comprehensive analysis impact material hints cell-material interactions tridimensional context provided.

Language: Английский

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