Trends in Food Science & Technology,
Journal Year:
2023,
Volume and Issue:
138, P. 323 - 338
Published: June 21, 2023
Metal-Organic
Frameworks
(MOFs),
a
relatively
new
category
of
materials
which
came
into
attention
about
two
decades
ago,
have
caught
researchers
across
industrial
sectors
including
food
additives,
flavor,
packaging
and
sensing.
More
than
100,000
such
structures
been
synthesized,
approximately
500,000
theoretically
determined.
However,
most
these
are
synthesized
using
transition
metal
ions
petroleum
derived
ligands
creates
cytotoxicity
sustainability
related
concerns,
respectively.
Additional
challenges
with
MOFs
include
thermal,
moisture,
hydrothermal
stability
as
well
pH
sensitivity,
reusability
scalability.
To
mitigate
the
environmental,
toxicological
utilized
bio-compatible
edible
linkers
polyphenols,
cyclodextrins,
peptides,
amino
acids
etc.
linked
non-toxic
cations
endogenous/intercellular
Zn2+,
Fe2+,
Fe3+
Mg2+,
Ca2+,
K+
among
others.
Other
factors
hinder
real-life
applications
thermal
or
stability,
application
medium,
food-contact
concerns.
This
paper
systematically
provides
an
overview
various
coordination
ability,
acid
dissociation
constant
bond
orbitals
others
links
them
to
reusability.
Various
made
from
edible,
biocompatible,
biological
endogenous
suitable
for
food,
contact
identified.
Structure,
porosity
physical
properties
MOF
families
summarized.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(6), P. 3013 - 3036
Published: Feb. 26, 2024
The
immune
system's
complexity
and
ongoing
evolutionary
struggle
against
deleterious
pathogens
underscore
the
value
of
vaccination
technologies,
which
have
been
bolstering
human
immunity
for
over
two
centuries.
Despite
noteworthy
advancements
these
200
years,
three
areas
remain
recalcitrant
to
improvement
owing
environmental
instability
biomolecules
used
in
vaccines─the
challenges
formulating
them
into
controlled
release
systems,
their
need
constant
refrigeration
avoid
loss
efficacy,
requirement
that
they
be
delivered
via
needle
gastrointestinal
incompatibility.
Nanotechnology,
particularly
metal–organic
frameworks
(MOFs)
covalent
organic
(COFs),
has
emerged
as
a
promising
avenue
confronting
challenges,
presenting
new
frontier
vaccine
development.
Although
materials
widely
explored
context
drug
delivery,
imaging,
cancer
immunotherapy,
role
immunology
vaccine-related
applications
is
recent
yet
rapidly
developing
field.
This
review
seeks
elucidate
prospective
use
MOFs
COFs
biomaterial
stabilization,
eliminating
necessity
cold
chains,
enhancing
antigen
potency
adjuvants,
potentializing
needle-free
delivery
vaccines.
It
provides
an
expansive
critical
viewpoint
on
this
evolving
field
research
emphasizes
vital
contribution
chemists
driving
further
advancements.
Advanced Composites and Hybrid Materials,
Journal Year:
2024,
Volume and Issue:
7(1)
Published: Jan. 22, 2024
Abstract
The
present
study
proposed
an
innovative
nanocomposite
aimed
at
enhancing
gene
and
drug
delivery
for
cancer
treatment.
was
composed
of
amine-functionalized
metal–organic
frameworks,
(NH
2
)-MIL-125(Ti),
conjugated
to
poly(aniline-
co
-para-phenylenediamine),
coated
on
manganese
ferrite
nanoparticles
that
were
utilized
co-deliver
the
chemotherapy
doxorubicin
(DOX)
plasmid
CRISPR
(pCRISPR)
cells.
investigation
focused
whether
surface
modification
with
amine
groups
could
improve
cellular
uptake
transfection
efficiency.
In
addition,
also
engineered
cell-imprinted
substrate
mimic
environment
enhance
expression
edited
genes.
results
demonstrated
nanocarriers
successfully
co-delivered
DOX
pCRISPR,
indicating
their
potential
combination
therapy.
Specific
highlights
include
(1)
reliable
platform
multi-drug
based
)-MIL-125(Ti)/poly(aniline-
-para-phenylenediamine)/MnFe
O
4
structure;
(2)
hemocompatibility
analysis
revealed
less
than
1%
hemolysis,
pointing
biosafety;
(3)
enhanced
up
38.3%
in
A549
cells,
improving
transfection;
(4)
therapeutic
efficacy
by
promoting
a
physiologically
relevant
microenvironment.
Overall,
this
makes
significant
contributions
nanocomposite,
modification,
cell-mimetic
employ
strategies
augment
therapy
against
cancer.
Graphical
RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(41), P. 30201 - 30229
Published: Jan. 1, 2024
Recently,
metal-organic
frameworks
(MOFs)
have
attracted
much
attention
as
versatile
materials
for
drug
delivery
and
personalized
medicine.
MOFs
are
porous
structures
made
up
of
metal
ions
coupled
with
organic
ligands.
This
review
highlights
the
synthesis
techniques
used
to
design
specific
features
such
surface
area
pore
size,
encapsulation
within
not
only
improves
their
stability
solubility
but
also
allows
controlled
release
kinetics,
which
therapeutic
efficacy
minimizes
adverse
effects.
Furthermore,
it
discusses
challenges
potential
advantages
MOF-based
delivery,
MOF
stability,
biocompatibility,
scale-up
production.
With
further
advancements
in
synthesis,
functionalization
techniques,
understanding
interactions
using
biological
systems,
can
significant
promise
expanding
medicine
improving
patient
outcomes.
Results in Chemistry,
Journal Year:
2024,
Volume and Issue:
7, P. 101414 - 101414
Published: Jan. 1, 2024
Metal-organic
frameworks
(MOFs)
have
emerged
as
a
class
of
versatile
materials,
finding
extensive
applications
in
drug
delivery
because
their
unique
properties
and
flexible
design.
This
comprehensive
review
aims
to
give
broad
perspective
on
the
recent
advancements
area
using
MOFs.
The
fundamental
characteristics
MOFs,
highlighting
exceptional
porosity,
high
surface
area,
tuneable
framework
structures,
enable
MOFs
serve
ideal
carriers,
allowing
efficient
loading
controlled
release.
delves
into
various
ligands
metal
ions
employed
for
encapsulation.
These
include
physical
encapsulation,
covalent
bonding,
host-guest
interactions,
each
offering
distinct
advantages
diverse
types
drugs
therapeutic
applications.
importance
tailoring
MOF
optimize
capacity,
stability,
release
kinetics
has
been
emphasized.
Additionally,
explorations
involve
delving
mechanisms
from
with
factors
such
pH,
temperature,
external
stimuli
that
can
be
harnessed
trigger
utilization
combination
therapies,
co-delivery
multiple
or
integrating
imaging
agents,
also
examined.
Numerous
examples
used
delivery,
encompassing
both
in-vitro
in-vivo
studies,
covering
wide
range
areas,
including
cancer
treatment,
antimicrobial
therapy,
targeted
are
included.
addresses
challenges
future
perspectives
development
delivery.
Strategies
improve
biocompatibility,
scalability
discussed,
along
understanding
MOF-drug
interaction
potential
toxicity
concerns.
With
properties,
capacities,
capabilities,
hold
capabilities
promise
enhance
efficacy
interventions.
Continued
research
this
pave
way
translation
clinical
near
future.
