Environmentally benign bioderived, biocompatible, thermally stable MOFs suitable for food contact applications DOI Creative Commons
Ajay Kathuria, Amro El Badawy,

Saleh Al-Ghamdi

et al.

Trends in Food Science & Technology, Journal Year: 2023, Volume and Issue: 138, P. 323 - 338

Published: June 21, 2023

Metal-Organic Frameworks (MOFs), a relatively new category of materials which came into attention about two decades ago, have caught researchers across industrial sectors including food additives, flavor, packaging and sensing. More than 100,000 such structures been synthesized, approximately 500,000 theoretically determined. However, most these are synthesized using transition metal ions petroleum derived ligands creates cytotoxicity sustainability related concerns, respectively. Additional challenges with MOFs include thermal, moisture, hydrothermal stability as well pH sensitivity, reusability scalability. To mitigate the environmental, toxicological utilized bio-compatible edible linkers polyphenols, cyclodextrins, peptides, amino acids etc. linked non-toxic cations endogenous/intercellular Zn2+, Fe2+, Fe3+ Mg2+, Ca2+, K+ among others. Other factors hinder real-life applications thermal or stability, application medium, food-contact concerns. This paper systematically provides an overview various coordination ability, acid dissociation constant bond orbitals others links them to reusability. Various made from edible, biocompatible, biological endogenous suitable for food, contact identified. Structure, porosity physical properties MOF families summarized.

Language: Английский

Advances in Nanoparticles for Effective Delivery of RNA Therapeutics DOI Open Access
Min Ji Byun, Jaesung Lim, Se−Na Kim

et al.

BioChip Journal, Journal Year: 2022, Volume and Issue: 16(2), P. 128 - 145

Published: March 3, 2022

Language: Английский

Citations

43
Core–shell inorganic NP@MOF nanostructures for targeted drug delivery and multimodal imaging-guided combination tumor treatment DOI Creative Commons
Suliman Khan, Mojtaba Falahati, William C. Cho

et al.

Advances in Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 321, P. 103007 - 103007

Published: Sept. 25, 2023

It is well known that metal-organic-framework (MOF) nanostructures have unique characteristics such as high porosity, large surface areas, and adjustable biofunctionalities, so they are ideal candidates for developing drug delivery systems (DDSs) theranostic platforms in cancer treatment. Despite the number of MOF been discovered, conventional MOF-derived nanosystems only a single biofunctional source poor colloidal stability. Accordingly, it has demonstrated core-shell with good stability useful method generating efficient delivery, multimodal imaging, synergistic therapeutic systems. The preparation done variety materials, but inorganic nanoparticles (NPs) found to be more effective imaging-guided tumor Herein, we aimed overview synthesis NPs@MOF followed by application MOFs derived from magnetic, quantum dots (QDs), gold (Au), gadolinium (Gd) NPs Afterwards, surveyed different factors affecting prolonged therapy, cellular uptake, biocompatibility, biodegradability, enhanced permeation retention (EPR) effect MOFs. Last not least, discussed challenges future prospects field. We envision this article may hold great promise providing valuable insights regarding hybrid promising potential combination therapy.

Language: Английский

Citations

37
Metal–Organic Frameworks and Their Biodegradable Composites for Controlled Delivery of Antimicrobial Drugs DOI Creative Commons
Tayah C. Livesey, Lila A. M. Mahmoud, Maria G. Katsikogianni

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(1), P. 274 - 274

Published: Jan. 12, 2023

Antimicrobial resistance (AMR) is a growing global crisis with an increasing number of untreatable or exceedingly difficult-to-treat bacterial infections, due to their existing drugs. It predicted that AMR will be the leading cause death by 2050. In addition ongoing efforts on preventive strategies and infection control, there research towards development novel vaccines, antimicrobial agents, optimised diagnostic practices address AMR. However, developing new therapeutic agents medicines can lengthy process. Therefore, parallel worldwide effort develop materials for drug delivery improve efficacy minimise Examples such include functionalisation surfaces so they become self-disinfecting non-fouling, nanoparticles promising properties attributed ability damage numerous essential components pathogens. A relatively class materials, metal-organic frameworks (MOFs), also being investigated act as carriers because ultrahigh porosity modular structures, which engineered control mechanism loaded Biodegradable polymers have been found show applications carriers; and, recently, several studies reported drugs using composites MOF biodegradable polymers. This review article reflects MOFs polymer-MOF composites, drugs, studied provides overview state art in this highly topical area research.

Language: Английский

Citations

31
Preparation, Characterization, and Wound Healing Assessment of Curcumin-Loaded M-MOF (M = Cu, Zn)@Polycaprolactone Nanocomposite Sponges DOI
Zeinab Ansari‐Asl,

Soghra Nikpour,

Tahereh Sedaghat

et al.

Applied Biochemistry and Biotechnology, Journal Year: 2023, Volume and Issue: 195(7), P. 4308 - 4320

Published: Jan. 23, 2023

Language: Английский

Citations

31
Environmentally benign bioderived, biocompatible, thermally stable MOFs suitable for food contact applications DOI Creative Commons
Ajay Kathuria, Amro El Badawy,

Saleh Al-Ghamdi

et al.

Trends in Food Science & Technology, Journal Year: 2023, Volume and Issue: 138, P. 323 - 338

Published: June 21, 2023

Metal-Organic Frameworks (MOFs), a relatively new category of materials which came into attention about two decades ago, have caught researchers across industrial sectors including food additives, flavor, packaging and sensing. More than 100,000 such structures been synthesized, approximately 500,000 theoretically determined. However, most these are synthesized using transition metal ions petroleum derived ligands creates cytotoxicity sustainability related concerns, respectively. Additional challenges with MOFs include thermal, moisture, hydrothermal stability as well pH sensitivity, reusability scalability. To mitigate the environmental, toxicological utilized bio-compatible edible linkers polyphenols, cyclodextrins, peptides, amino acids etc. linked non-toxic cations endogenous/intercellular Zn2+, Fe2+, Fe3+ Mg2+, Ca2+, K+ among others. Other factors hinder real-life applications thermal or stability, application medium, food-contact concerns. This paper systematically provides an overview various coordination ability, acid dissociation constant bond orbitals others links them to reusability. Various made from edible, biocompatible, biological endogenous suitable for food, contact identified. Structure, porosity physical properties MOF families summarized.

Language: Английский

Citations

31