Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(12)
Published: Jan. 26, 2024
Abstract
Currently,
the
secondary
development
and
modification
of
clinical
drugs
has
become
one
research
priorities.
Researchers
have
developed
a
variety
TME‐responsive
nanomedicine
carriers
to
solve
certain
problems.
Unfortunately,
endogenous
stimuli
such
as
reactive
oxygen
species
(ROS),
an
important
prerequisite
for
effective
therapeutic
efficacy,
are
not
enough
achieve
expected
drug
release
process,
therefore,
it
is
difficult
continuous
efficient
treatment
process.
Herein,
self‐supply
ROS‐responsive
cascade
polyprodrug
(PMTO)
designed.
The
encapsulation
chemotherapy
mitoxantrone
(MTO)
in
polymer
backbone
could
effectively
reduce
systemic
toxicity
when
transported
vivo.
After
PMTO
degraded
by
ROS
TME,
another
part
becomes
cinnamaldehyde
(CA),
which
can
further
enhance
intracellular
ROS,
thereby
achieving
sustained
Meanwhile,
due
disruption
redox
environment,
efficacy
enhanced.
Finally,
anticancer
enhanced
mild
hyperthermia
effect
PMTO.
In
conclusion,
designed
demonstrates
remarkable
antitumor
addressing
limitations
associated
with
MTO.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(47)
Published: March 20, 2023
Abstract
Organic
coatings
are
one
of
the
most
popular
and
powerful
strategies
for
protecting
metals
against
corrosion.
They
can
be
applied
in
different
ways,
such
as
by
dipping,
spraying,
electrophoresis,
casting,
painting,
or
flow
coating.
offer
great
flexibility
material
designs
cost
effectiveness.
Moreover,
self‐healing
has
evolved
a
new
research
topic
protective
organic
last
two
decades.
Responsive
materials
play
crucial
role
this
field.
However,
targeting
development
high‐performance
corrosion
protection,
it
is
not
sufficient
just
to
focus
on
smart
responsive
suitable
active
agents
self‐healing.
A
better
understanding
how
react
stimuli
induced
corrosion,
these
spread
coating,
released
reach
corroding
defect
also
high
importance.
Such
knowledge
would
allow
design
that
optimized
specific
applications.
Herein,
requirements
possibilities
from
synthesis
perspectives
designing
preparing
protection
discussed.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(36)
Published: May 31, 2023
Photoresponsive
polymers
can
be
conveniently
used
to
fabricate
anti-counterfeiting
materials
through
photopatterning.
However,
an
unsolved
problem
is
that
ambient
light
and
heat
damage
patterns
on
photoresponsive
polymers.
Herein,
photo-
thermostable
are
developed
by
photopatterning
thermal
annealing
of
a
conjugated
polymer
(MC-Azo).
MC-Azo
contains
alternating
azobenzene
fluorene
units
in
the
backbone.
To
prepare
material,
film
irradiated
with
polarized
blue
photomask,
then
thermally
annealed
under
pressure
photonic
stamp.
This
strategy
generates
highly
secure
material
dual
patterns,
which
stable
sunlight
over
200
°C.
A
key
for
stability
promotes
interchain
stacking,
converts
photostable
material.
Another
structure
endows
desirable
properties.
study
shows
design
photopatternable
thermal-annealing-promoted
stacking
provides
new
development
materials.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(25)
Published: April 4, 2024
Active
transcytosis-mediated
nanomedicine
transport
presents
considerable
potential
in
overcoming
diverse
delivery
barriers,
thereby
facilitating
tumor
accumulation
and
penetration.
Nevertheless,
the
persistent
challenge
lies
achieving
a
nuanced
equilibrium
between
intracellular
interception
for
drug
release
transcytosis
In
this
study,
comprehensive
exploration
is
conducted
involving
series
of
polyglutamine-paclitaxel
conjugates
featuring
distinct
hydrophilic/hydrophobic
ratios
(HHR)
tertiary
amine-oxide
proportions
(TP)
(OPGA-PTX).
The
screening
process,
meticulously
focused
on
delineating
their
subcellular
distribution,
capability,
penetration,
unveils
particularly
promising
candidate
denoted
as
OPPX,
characterized
by
an
HHR
10:1
TP
100%.
distinguished
its
rapid
cellular
internalization
through
multiple
endocytic
pathways,
selectively
engages
trafficking
to
Golgi
apparatus
facilitate
within
penetration
throughout
tissues
simultaneously
sorted
lysosomes
cathepsin
B-activated
release.
This
study
not
only
identifies
OPPX
exemplary
but
also
underscores
feasibility
modulating
distribution
optimize
active
capabilities
mechanisms
nanomedicines,
providing
alternative
approach
designing
efficient
anticancer
nanomedicines.
Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(32), P. 17755 - 17766
Published: Aug. 1, 2023
Precise
activation
of
polymer
nanoparticles
at
lesion
sites
is
crucial
to
achieve
favorable
therapeutic
efficacy.
However,
conventional
endogenous
stimuli-responsive
probably
suffer
from
few
triggers
stimulate
the
degradation
and
subsequent
functions.
Here,
we
describe
oxidation-responsive
poly(ferrocene)
amphiphiles
containing
phenylboronic
acid
ester
ferrocene
as
repeating
backbone
units.
Upon
triggering
by
hydrogen
peroxide
inside
tumor
cells,
bonds
are
broken
units
degraded
afford
free
noticeable
hydroxide
ions.
The
released
ions
can
immediately
improve
pH
value
within
aggregates,
rate
further
promoted
upregulated
pH;
thereupon,
accelerated
release
much
more
additional
pH,
thus
achieving
a
positive
self-amplified
cascade
aggregates
accompanied
oxidative
stress
boosting
efficient
cargo
release.
Specifically,
be
up
∼90%
12
h
when
triggered
H2O2,
while
ferrocene-free
control
only
30%
days.
In
addition,
maleimide
moieties
tethered
in
hydrophilic
corona
capture
blood
albumin
form
an
albumin-rich
protein
significantly
accumulation.
current
efficiently
inhibit
tumors
vitro
vivo.
This
work
provides
proof-of-concept
paradigm
for
concurrent
stress,
which
promising
actively
regulated
precision
medicine.
