Near–Infrared Heptamethine Cyanine Photosensitizers with Efficient Singlet Oxygen Generation for Anticancer Photodynamic Therapy DOI Open Access
Wenkai Liu, Shan He,

Xue Ma

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(47)

Published: July 31, 2024

Abstract Near‐infrared photosensitizers are valuable tools to improve treatment depth in photodynamic therapy (PDT). However, their low singlet oxygen ( 1 O 2 ) generation ability, indicated by quantum yield, presents a formidable challenge for PDT. To overcome this challenge, the heptamethine cyanine was decorated with biocompatible S Scy7 and Se Secy7 atom. We observe that exhibits redshift main absorption ~840 nm an ultra‐efficient capacity. The emergence of strong intramolecular charge transfer effect between atom polymethine chain considerably narrows energy gap (0.51 eV), heavy strengthens spin–orbit coupling (1.44 cm −1 ), both which greatly improved high triplet state yield (61 %), determines . Therefore, demonstrated excellent capacity, is ~24.5‐fold indocyanine green, ~8.2‐fold IR780, ~1.3‐fold methylene blue under low‐power‐density 850 irradiation (5 mW −2 ). considerable phototoxicity toward cancer cells buried 12 mm tissue. Nanoparticles formed encapsulating within amphiphilic polymers lecithin, promising antitumor anti‐pulmonary metastatic effects, exhibiting remarkable potential advancing PDT deep tissues.

Language: Английский

Formation of reactive species via high power microwave induced DNA damage and promoted intrinsic pathway-mediated apoptosis in lung cancer cells: An in vitro investigation DOI Creative Commons
Juie Nahushkumar Rana, Sohail Mumtaz, Ihn Han

et al.

Fundamental Research, Journal Year: 2024, Volume and Issue: 4(6), P. 1542 - 1556

Published: Feb. 8, 2024

Lung cancer continues to be the second most common diagnosed and main cause of cancer-related death globally, which requires novel effective treatment strategies. When considering options, non-small cell lung (NSCLC) remained a challenge, seeking new therapeutic High-power microwave (HPM) progressions have facilitated advancement technologies as well improvements those already in use. The impact HPM on NSCLC has not been investigated before. In this work, we uncovered effect pulsed (H460 A549) for first time likely underlying mechanisms. Two cells normal MRC5 were exposed (15, 30, 45, 60) pulses (2.06 mJ/pulse). After exposure, effects observed at 12, 24, 48, 72 hours. primarily increases level intracellular reactive species by strong electric field ∼27 kV/cm, altered viability, mitochondrial activity, rates. A model production was also presented. is found affected through DNA damage (upregulation ATR/ATM, Chk1/Chk2, P53) increased expression apoptotic markers. NAC scavenger CPTIO-inhibitor confirm that are mainly accountable cellular effects. order ensure suitability real-world usage, skin depth calculated 30 mm. ROS played role inducing effects, with NO possibly playing contributing role. These findings clarify mechanisms HPM-induced death, potentially advancing approaches treating NSCLC, useful step future investigations area. Moreover, technique potential serve an adjunct non-surgical methods therapy.

Language: Английский

Citations

13
DNA-Targeting Bioactive Photosensitizer for Chemo-Photodynamic Therapy of Malignant Tumor DOI
Yu Tian, Li Wang,

Yunyun Qian

et al.

ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(3), P. 969 - 975

Published: Feb. 15, 2024

The design of a biologically active photosensitizer that effectively combines chemotherapy and photodynamic therapy remains significant challenge. This article introduces DNA targeted photosensitizer, CQA, which integrates the alkylating moiety chlormethine with photosensitizing moiety. Through damage experiments molecular docking, CQA has been demonstrated to act as an effective targeting damaging chemotherapeutic agent via chlormethine. Meanwhile, can substantially amplify under light irradiation. Such enhancement is attributed introduction anthraquinone group, possesses good redox properties acts electron acceptor promote transfer. Consequently, efficiently generates both type-I type-II reactive oxygen species (ROS), exerting excellent (PDT) effect. antitumor efficacy validated results from in vivo tumor growth experiments, H&E staining, IHC analyses. this study emphasizes enhanced ROS generation, underscoring crucial role efficient synergistic chemo- advancing cancer treatment strategies.

Language: Английский

Citations

11
Sonodynamic Therapy‐Driven Immunotherapy: Constructing AIE Organic Sonosensitizers Using an Advanced Receptor‐Regulated Strategy DOI

Mengyan Tian,

Yucong Li,

Yaning Li

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: May 16, 2024

Abstract Benefit from the deeper penetration of mechanical wave, ultrasound (US)‐based sonodynamic therapy (SDT) executes gratifying efficacy in treating deep‐seated tumors. Nevertheless, complicated mechanism SDT undeniably hinders exploration ingenious sonosensitizers. Herein, a receptor engineering strategy aggregation‐induced emission (AIE) sonosensitizers (TPA‐Tpy) with acceptor (A)‐donor (D)‐A’ structure is proposed, which inspects effect increased cationizations on US sensitivity. Under stimulation, enhanced cationization TPA‐Tpy improves intramolecular charge transfer (ICT) and accelerates separation, possesses non‐negligible promotion type I reactive oxygen species (ROS) production. Moreover, abundant ROS‐mediated mitochondrial oxidative stress triggers satisfactory immunogenic cell death (ICD), further promotes combination ICD. Subsequently, subacid pH‐activated nanoparticles (TPA‐Tpy NPs) are constructed charge‐converting layer (2,3‐dimethylmaleic anhydride‐poly (allylamine hydrochloride)‐polyethylene glycol (DMMA‐PAH‐PEG)) TPA‐Tpy, achieving controllable release In vivo, TPA‐Tpy‐mediated effectively initiates surface‐exposed calreticulin (ecto‐CRT), dendritic cells (DCs) maturation, CD8 + T infiltration rate through ROS production, suppression ablation primary metastatic This study provides new opinions regulating acceptors eminent sensitization, brings novel ICD sono‐inducer based to realize superior antitumor effect.

Language: Английский

Citations

10
Protein nanoparticles as drug delivery systems for cancer theranostics DOI

Yue Hua,

Zibo Qin,

Lin Gao

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 371, P. 429 - 444

Published: June 8, 2024

Language: Английский

Citations

10
Near–Infrared Heptamethine Cyanine Photosensitizers with Efficient Singlet Oxygen Generation for Anticancer Photodynamic Therapy DOI Open Access
Wenkai Liu, Shan He,

Xue Ma

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(47)

Published: July 31, 2024

Abstract Near‐infrared photosensitizers are valuable tools to improve treatment depth in photodynamic therapy (PDT). However, their low singlet oxygen ( 1 O 2 ) generation ability, indicated by quantum yield, presents a formidable challenge for PDT. To overcome this challenge, the heptamethine cyanine was decorated with biocompatible S Scy7 and Se Secy7 atom. We observe that exhibits redshift main absorption ~840 nm an ultra‐efficient capacity. The emergence of strong intramolecular charge transfer effect between atom polymethine chain considerably narrows energy gap (0.51 eV), heavy strengthens spin–orbit coupling (1.44 cm −1 ), both which greatly improved high triplet state yield (61 %), determines . Therefore, demonstrated excellent capacity, is ~24.5‐fold indocyanine green, ~8.2‐fold IR780, ~1.3‐fold methylene blue under low‐power‐density 850 irradiation (5 mW −2 ). considerable phototoxicity toward cancer cells buried 12 mm tissue. Nanoparticles formed encapsulating within amphiphilic polymers lecithin, promising antitumor anti‐pulmonary metastatic effects, exhibiting remarkable potential advancing PDT deep tissues.

Language: Английский

Citations

10