Inorganic–organic hybrid nanomaterials for photothermal antibacterial therapy

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 496, P. 215426 - 215426

Published: Sept. 6, 2023

Language: Английский

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Self-Driven Electron Transfer Biomimetic Enzymatic Catalysis of Bismuth-Doped PCN-222 MOF for Rapid Therapy of Bacteria-Infected Wounds

ACS Nano, Journal Year: 2023, Volume and Issue: 17(2), P. 1448 - 1463

Published: Jan. 9, 2023

In this work, a biomimetic nanozyme catalyst with rapid and efficient self-bacteria-killing wound-healing performances was synthesized. Through an in situ reduction reaction, PCN-222 metal organic framework (MOF) doped bismuth nanoparticles (Bi NPs) to form Bi-PCN-222, interfacial Schottky heterojunction catalyst, which can kill 99.9% of Staphylococcus aureus (S. aureus). The underlying mechanism that Bi NP doping endow Bi-PCN-222 MOF self-driven charge transfer through the interface capability oxidase-like peroxidase-like activity, because large number free electrons be captured by surrounding oxygen species produce radical (ROS). Furthermore, once bacteria contact physiological environment, its appropriate redox potential trigger electron transport pathway bacterial membranes then interior bacteria, disturbs respiration process subsequent metabolism. Additionally, also accelerate tissue regeneration upregulating fibroblast proliferation angiogenesis genes (bFGF, VEGF, HIF-1α), thereby promoting wound healing. This enzyme-catalyzed strategy will bring enlightenment design self-bacterial agents for disinfection reconstruction simultaneously.

Language: Английский

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Nanomaterials-based photothermal therapies for antibacterial applications

Materials & Design, Journal Year: 2023, Volume and Issue: 233, P. 112231 - 112231

Published: Aug. 9, 2023

Bacterial infection continues to be one of the biggest threats human health. The therapeutic effect is significantly reduced as a result development super-bacteria-resistant bacteria due overuse antibiotics for conventional antimicrobial treatment. emergence drug-resistant makes it necessary develop new treatments. Following successful application photothermal therapy in field oncology treatment, more and researchers are applying treatments achieving important results, especially treatment bacterial infections. As non-invasive anti-infection method, has advantages broad-spectrum properties, short period, low systemic impact. In PTT, efficacy strongly depends on different laser properties choice agents (PTAs). purpose this review discuss most recent developments nanomaterials that antibacterial. We will delve into principles spectrum PTAs provide summary current synthesis, classification, structural features, physicochemical antibacterial performance research. challenges future prospects enhanced cytotoxicity investigated.

Language: Английский

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Biomaterials releasing drug responsively to promote wound healing via regulation of pathological microenvironment

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 196, P. 114778 - 114778

Published: March 16, 2023

Language: Английский

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Photodynamic Alginate Zn-MOF Thermosensitive Hydrogel for Accelerated Healing of Infected Wounds

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(19), P. 22830 - 22842

Published: May 2, 2023

Antibiotic resistance reduces the effectiveness of infected wound healing, and it is necessary to develop a new strategy promote healing without using antibiotics. Here, we Chlorin e6 (Ce6)-loaded zinc-metal-organic framework (MOF) thermosensitive hydrogel (Ce6@MOF-Gel) based on alginate poly(propylene glycol) 407, which enhances antibacterial effects promotes by novel combining zinc-MOF with photodynamic therapy (PDT). Zinc-MOF can realize acid-responsive release Ce6 improve performance drug destroying integrity bacterial cell membranes enhancing production reactive oxygen species (ROS). Additionally, Ce6@MOF-Gel stability, solubility, properties Ce6. More importantly, inflammation collagen deposition re-epithelialization facilitate healing. Collectively, MOF-based provides new, efficient, safe way for accelerated wounds.

Language: Английский

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Enhanced interfacial charge transfer and photothermal effect via in-situ construction of atom co-sharing Bi plasmonic/Bi4O5Br2 nanosheet heterojunction towards improved full-spectrum photocatalysis

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 459, P. 141557 - 141557

Published: Jan. 25, 2023

Language: Английский

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A Photo‐Therapeutic Nanocomposite with Bio‐Responsive Oxygen Self‐Supplying Combats Biofilm Infections and Inflammation from Drug‐Resistant Bacteria

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(37)

Published: May 25, 2023

Abstract The use of non‐antibiotic strategies to combat refractory drug‐resistant bacterial infections, especially biofilms and accompanying inflammation, has recently aroused widespread interest. Herein, a photo‐therapeutic nanocomposite with bio‐responsive oxygen (O 2 ) self‐supplying is introduced by integrating manganese dioxide (MnO nanozymes onto photosensitizer (indocyanine green, ICG)‐loaded mesoporous polydopamine nanoparticles (MPDA), namely MI‐MPDA NPs. can activate O generation in the infection microenvironment, thereby effectively alleviating biofilm hypoxia. Under near‐infrared light (NIR) irradiation, continuous supplying further boosts level singlet ( 1 ), enabling robust elimination through ‐potentiated photodynamic/photothermal therapy. Interestingly, down‐regulates factor expression inflammatory signaling pathways MnO ‐mediated reactive species scavenging, which ameliorates condition. Meanwhile, prevents M1‐phenotype switch macrophages from overexpression hypoxia‐inducible factor‐1 α (HIF‐1 prompting macrophage reprogramming toward pro‐regenerative M2‐phenotype. In mouse models subcutaneous implant‐associated caused methicillin‐resistant Staphylococcus aureus (MRSA) burn Pseudomonas aeruginosa biofilms, NIR‐irradiated not only eliminates formed but also alleviates oxidative stress drives cascade reaction immunomodulation‐wound healing. Overall, this strategy provides reliable tool for combating infections inflammation bacteria.

Language: Английский

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Nanomaterials-Based Wound Dressing for Advanced Management of Infected Wound

Antibiotics, Journal Year: 2023, Volume and Issue: 12(2), P. 351 - 351

Published: Feb. 8, 2023

The effective prevention and treatment of bacterial infections is imperative to wound repair the improvement patient outcomes. In recent years, nanomaterials have been extensively applied in infection control healing due their special physiochemical biological properties. Incorporating antibacterial into dressing has associated with improved biosafety enhanced outcomes compared naked nanomaterials. this review, we discuss progress application nanomaterial-based dressings for advanced management infected wounds. Focus given therapy as well all-in-one detection infections. Notably, highlight use nanoparticles intrinsic performances, such metals metal oxide that are capable killing bacteria reducing drug-resistance through multiple antimicrobial mechanisms. addition, proven be ideal drug carriers delivery release antimicrobials either passive or stimuli-responsive manners. ability kill based on photo-triggered heat (photothermal therapy) ROS (photodynamic therapy), unparalleled advantages control. Moreover, examples intelligent can detect in-situ while providing timely Finally, challenges current provide further perspectives future healing.

Language: Английский

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Nacre‐Inspired Metal‐Organic Framework Coatings Reinforced by Multiscale Hierarchical Cross‐linking for Integrated Antifouling and Anti‐Microbial Corrosion

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(47)

Published: July 26, 2023

Abstract A long‐standing quest in marine materials science has been the development of tough and effective antifouling coatings for diverse surface protection. However, most commercial are severely limited by poor mechanical behavior unsustainable passive biocidal effect, leading to irreversible biofouling even microbiologically influenced corrosion (MIC). Herein, inspired amorphous/crystalline feature within nacreous platelets, a mechanically robust coating composed biopolymer‐based hydrogel dense metal‐organic frameworks (MOFs) is developed. Tailoring cross‐linked networks across multiscale interfaces can furnish strength, dissipate strain, improve toughness building blocks, resulting firm scalable configuration on various substrates regardless material category topology. The resultant as suitable reservoir exhibits unique active defensive intelligent MOF degradation or drug release, enabling groundbreaking performance broad‐spectrum control. Notably, neither attachment organisms nor MIC metal observed aggravated during prolonged testing process complex biological environments. This study provides distinctive insights into underlying multimechanisms comprehensive anti‐fouling‐corrosion pioneer rational strategy design next‐generation reliable MOFs‐derived

Language: Английский

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Recent Development of Copper‐Based Nanozymes for Biomedical Applications

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 13(1)

Published: Sept. 24, 2023

Copper (Cu), an indispensable trace element within the human body, serving as intrinsic constituent of numerous natural enzymes, carrying out vital biological functions. Furthermore, nanomaterials exhibiting enzyme-mimicking properties, commonly known nanozymes, possess distinct advantages over their enzyme counterparts, including cost-effectiveness, enhanced stability, and adjustable performance. These advantageous attributes have captivated attention researchers, inspiring them to devise various Cu-based nanomaterials, such copper oxide, Cu metal-organic framework, CuS, explore potential in enzymatic catalysis. This comprehensive review encapsulates most recent advancements illuminating applications realm biochemistry. Initially, it is delved into emulation typical types achieved by nanomaterials. Subsequently, latest breakthroughs concerning nanozymes biochemical sensing, bacterial inhibition, cancer therapy, neurodegenerative diseases treatment discussed. Within this segment, also explored modulation nanozyme activity. Finally, a visionary outlook for future development presented.

Language: Английский

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