Layered Double Hydroxides: A Novel Promising 2D Nanomaterial for Bone Diseases Treatment DOI Creative Commons
Yixin Bian,

Xuejie Cai,

Zehui Lv

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(24)

Published: June 17, 2023

Bone diseases including bone defects, infections, osteoarthritis, and tumors seriously affect life quality of the patient bring serious economic burdens to social health management, for which current clinical treatments bear dissatisfactory therapeutic effects. Biomaterial-based strategies have been widely applied in treatment orthopedic but are still plagued by deficient bioreactivity. With development nanotechnology, layered double hydroxides (LDHs) with adjustable metal ion composition alterable interlayer structure possessing charming physicochemical characteristics, versatile bioactive properties, excellent drug loading delivery capabilities arise widespread attention achieved considerable achievements disease last decade. However, authors' best knowledge, no review has comprehensively summarized advances LDHs treating so far. Herein, advantages disorders outlined corresponding state-of-the-art first time. The potential LDHs-based nanocomposites extended therapeutics is highlighted perspectives scaffold design proposed facilitated translation.

Language: Английский

Inorganic–organic hybrid nanomaterials for photothermal antibacterial therapy DOI
Xiaoliang Qi,

Yajing Xiang,

Erya Cai

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 496, P. 215426 - 215426

Published: Sept. 6, 2023

Language: Английский

Citations

133
Self-Driven Electron Transfer Biomimetic Enzymatic Catalysis of Bismuth-Doped PCN-222 MOF for Rapid Therapy of Bacteria-Infected Wounds DOI

Lihua Wu,

Yue Luo,

Chaofeng Wang

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(2), P. 1448 - 1463

Published: Jan. 9, 2023

In this work, a biomimetic nanozyme catalyst with rapid and efficient self-bacteria-killing wound-healing performances was synthesized. Through an in situ reduction reaction, PCN-222 metal organic framework (MOF) doped bismuth nanoparticles (Bi NPs) to form Bi-PCN-222, interfacial Schottky heterojunction catalyst, which can kill 99.9% of Staphylococcus aureus (S. aureus). The underlying mechanism that Bi NP doping endow Bi-PCN-222 MOF self-driven charge transfer through the interface capability oxidase-like peroxidase-like activity, because large number free electrons be captured by surrounding oxygen species produce radical (ROS). Furthermore, once bacteria contact physiological environment, its appropriate redox potential trigger electron transport pathway bacterial membranes then interior bacteria, disturbs respiration process subsequent metabolism. Additionally, also accelerate tissue regeneration upregulating fibroblast proliferation angiogenesis genes (bFGF, VEGF, HIF-1α), thereby promoting wound healing. This enzyme-catalyzed strategy will bring enlightenment design self-bacterial agents for disinfection reconstruction simultaneously.

Language: Английский

Citations

108
Nanomaterials-based photothermal therapies for antibacterial applications DOI Creative Commons
Hao Liu, Fei Xing, Yuxi Zhou

et al.

Materials & Design, Journal Year: 2023, Volume and Issue: 233, P. 112231 - 112231

Published: Aug. 9, 2023

Bacterial infection continues to be one of the biggest threats human health. The therapeutic effect is significantly reduced as a result development super-bacteria-resistant bacteria due overuse antibiotics for conventional antimicrobial treatment. emergence drug-resistant makes it necessary develop new treatments. Following successful application photothermal therapy in field oncology treatment, more and researchers are applying treatments achieving important results, especially treatment bacterial infections. As non-invasive anti-infection method, has advantages broad-spectrum properties, short period, low systemic impact. In PTT, efficacy strongly depends on different laser properties choice agents (PTAs). purpose this review discuss most recent developments nanomaterials that antibacterial. We will delve into principles spectrum PTAs provide summary current synthesis, classification, structural features, physicochemical antibacterial performance research. challenges future prospects enhanced cytotoxicity investigated.

Language: Английский

Citations

79
Photodynamic Alginate Zn-MOF Thermosensitive Hydrogel for Accelerated Healing of Infected Wounds DOI

Wenshang Zhang,

Bingjie Wang, Guangli Xiang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(19), P. 22830 - 22842

Published: May 2, 2023

Antibiotic resistance reduces the effectiveness of infected wound healing, and it is necessary to develop a new strategy promote healing without using antibiotics. Here, we Chlorin e6 (Ce6)-loaded zinc-metal-organic framework (MOF) thermosensitive hydrogel (Ce6@MOF-Gel) based on alginate poly(propylene glycol) 407, which enhances antibacterial effects promotes by novel combining zinc-MOF with photodynamic therapy (PDT). Zinc-MOF can realize acid-responsive release Ce6 improve performance drug destroying integrity bacterial cell membranes enhancing production reactive oxygen species (ROS). Additionally, Ce6@MOF-Gel stability, solubility, properties Ce6. More importantly, inflammation collagen deposition re-epithelialization facilitate healing. Collectively, MOF-based provides new, efficient, safe way for accelerated wounds.

Language: Английский

Citations

72
Biomaterials releasing drug responsively to promote wound healing via regulation of pathological microenvironment DOI
Haisheng Li, Buying Li,

Dalun Lv

et al.

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 196, P. 114778 - 114778

Published: March 16, 2023

Language: Английский

Citations

71
Enhanced interfacial charge transfer and photothermal effect via in-situ construction of atom co-sharing Bi plasmonic/Bi4O5Br2 nanosheet heterojunction towards improved full-spectrum photocatalysis DOI

Xiaoyi Dong,

Liang Xu,

Junhao Ma

et al.

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 459, P. 141557 - 141557

Published: Jan. 25, 2023

Language: Английский

Citations

64
A Photo‐Therapeutic Nanocomposite with Bio‐Responsive Oxygen Self‐Supplying Combats Biofilm Infections and Inflammation from Drug‐Resistant Bacteria DOI
Yuan Zhang, Jianshuang Wu, Yao Xiao

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(37)

Published: May 25, 2023

Abstract The use of non‐antibiotic strategies to combat refractory drug‐resistant bacterial infections, especially biofilms and accompanying inflammation, has recently aroused widespread interest. Herein, a photo‐therapeutic nanocomposite with bio‐responsive oxygen (O 2 ) self‐supplying is introduced by integrating manganese dioxide (MnO nanozymes onto photosensitizer (indocyanine green, ICG)‐loaded mesoporous polydopamine nanoparticles (MPDA), namely MI‐MPDA NPs. can activate O generation in the infection microenvironment, thereby effectively alleviating biofilm hypoxia. Under near‐infrared light (NIR) irradiation, continuous supplying further boosts level singlet ( 1 ), enabling robust elimination through ‐potentiated photodynamic/photothermal therapy. Interestingly, down‐regulates factor expression inflammatory signaling pathways MnO ‐mediated reactive species scavenging, which ameliorates condition. Meanwhile, prevents M1‐phenotype switch macrophages from overexpression hypoxia‐inducible factor‐1 α (HIF‐1 prompting macrophage reprogramming toward pro‐regenerative M2‐phenotype. In mouse models subcutaneous implant‐associated caused methicillin‐resistant Staphylococcus aureus (MRSA) burn Pseudomonas aeruginosa biofilms, NIR‐irradiated not only eliminates formed but also alleviates oxidative stress drives cascade reaction immunomodulation‐wound healing. Overall, this strategy provides reliable tool for combating infections inflammation bacteria.

Language: Английский

Citations

46
Nanomaterials-Based Wound Dressing for Advanced Management of Infected Wound DOI Creative Commons
Qian Pang,

Zilian Jiang,

Kaihao Wu

et al.

Antibiotics, Journal Year: 2023, Volume and Issue: 12(2), P. 351 - 351

Published: Feb. 8, 2023

The effective prevention and treatment of bacterial infections is imperative to wound repair the improvement patient outcomes. In recent years, nanomaterials have been extensively applied in infection control healing due their special physiochemical biological properties. Incorporating antibacterial into dressing has associated with improved biosafety enhanced outcomes compared naked nanomaterials. this review, we discuss progress application nanomaterial-based dressings for advanced management infected wounds. Focus given therapy as well all-in-one detection infections. Notably, highlight use nanoparticles intrinsic performances, such metals metal oxide that are capable killing bacteria reducing drug-resistance through multiple antimicrobial mechanisms. addition, proven be ideal drug carriers delivery release antimicrobials either passive or stimuli-responsive manners. ability kill based on photo-triggered heat (photothermal therapy) ROS (photodynamic therapy), unparalleled advantages control. Moreover, examples intelligent can detect in-situ while providing timely Finally, challenges current provide further perspectives future healing.

Language: Английский

Citations

45
Recent Development of Copper‐Based Nanozymes for Biomedical Applications DOI
Xin Yu, Yawen Wang, Jian Zhang

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 13(1)

Published: Sept. 24, 2023

Copper (Cu), an indispensable trace element within the human body, serving as intrinsic constituent of numerous natural enzymes, carrying out vital biological functions. Furthermore, nanomaterials exhibiting enzyme-mimicking properties, commonly known nanozymes, possess distinct advantages over their enzyme counterparts, including cost-effectiveness, enhanced stability, and adjustable performance. These advantageous attributes have captivated attention researchers, inspiring them to devise various Cu-based nanomaterials, such copper oxide, Cu metal-organic framework, CuS, explore potential in enzymatic catalysis. This comprehensive review encapsulates most recent advancements illuminating applications realm biochemistry. Initially, it is delved into emulation typical types achieved by nanomaterials. Subsequently, latest breakthroughs concerning nanozymes biochemical sensing, bacterial inhibition, cancer therapy, neurodegenerative diseases treatment discussed. Within this segment, also explored modulation nanozyme activity. Finally, a visionary outlook for future development presented.

Language: Английский

Citations

42
MXenes-based adsorbents for environmental remediation DOI
Qiang Li,

Chunbing Ge,

J. Ma

et al.

Separation and Purification Technology, Journal Year: 2024, Volume and Issue: 342, P. 126982 - 126982

Published: March 4, 2024

Language: Английский

Citations

37