Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(13)
Published: Dec. 25, 2023
Abstract
Metal
nanoclusters
(NCs)
are
well‐recognized
novel
nano‐agents
that
hold
great
promise
for
applications
in
nanomedicine
because
of
their
ultrafine
size,
low
toxicity,
and
high
renal
clearance.
As
foreign
substances,
however,
an
in‐depth
understanding
the
bioresponses
to
metal
NCs
is
necessary
but
still
far
from
being
realized.
Herein,
this
review
deployed
summarize
biofates
at
various
biological
levels,
emphasizing
multiscale
molecular,
cellular,
organismal
levels.
In
parts‐to‐whole
schema,
interactions
between
biomolecules
discussed,
presenting
typical
protein‐dictated
nano–bio
interfaces,
hierarchical
structures,
vivo
trajectories.
Then,
accumulation,
internalization,
metabolic
evolution
cellular
environment
as‐imparted
theranostic
functionalization
demonstrated.
The
metabolism
transportation
processes
subsequently
distilled.
Finally,
ends
with
conclusions
perspectives
on
outstanding
issues
NC‐mediated
near
future.
This
expected
provide
inspiration
tailoring
customization
NC‐based
meet
practical
requirements
different
sectors
nanomedicine.
Nanoscale Horizons,
Journal Year:
2024,
Volume and Issue:
9(10), P. 1683 - 1702
Published: Jan. 1, 2024
This
review
focuses
on
recent
developments
in
understanding
the
fluorescence
mechanism
of
ultra-small
nanoparticles
sensors,
including
quantum
dots,
gold
nanoclusters,
and
carbon
dots.
Aggregate,
Journal Year:
2023,
Volume and Issue:
5(2)
Published: Oct. 5, 2023
Abstract
Designing
a
theranostic
probe
for
noninvasive
bone
imaging
and
disease
therapy
is
both
challenging
desirable.
Herein,
an
ultrasmall
Au
nanocluster
(NC,
<2
nm)‐based
developed
to
achieve
highly
temporospatial
in
vivo
bone‐targeted
photoluminescence
(PL)
the
second
near‐infrared
window
(NIR‐II)
enhanced
rheumatoid
arthritis
(RA)
therapy.
The
key
design
of
involves
surface
phosphorylation
atomically
precise
NIR‐II
emitting
44
NCs.
This
enhances
bone‐targeting
ability
due
concentrated
phosphate
groups,
allowing
realize
PL
imaging.
Moreover,
benefiting
from
ability,
hydrodynamic
diameter,
excellent
anti‐inflammation
immunomodulatory
effects,
not
only
demonstrates
superior
therapeutic
efficacy
RA
rats,
effectively
restoring
destructed
cartilage
nearly
normal
but
also
exhibits
good
renal
clearance
benign
biocompatibility.
These
favorable
attributes
cannot
be
achieved
by
commercial
methotrexate
used
treatment.
study
presents
new
paradigm
metal
NC‐based
probes,
offering
potential
high‐resolution
improved
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(13)
Published: Dec. 25, 2023
Abstract
Metal
nanoclusters
(NCs)
are
well‐recognized
novel
nano‐agents
that
hold
great
promise
for
applications
in
nanomedicine
because
of
their
ultrafine
size,
low
toxicity,
and
high
renal
clearance.
As
foreign
substances,
however,
an
in‐depth
understanding
the
bioresponses
to
metal
NCs
is
necessary
but
still
far
from
being
realized.
Herein,
this
review
deployed
summarize
biofates
at
various
biological
levels,
emphasizing
multiscale
molecular,
cellular,
organismal
levels.
In
parts‐to‐whole
schema,
interactions
between
biomolecules
discussed,
presenting
typical
protein‐dictated
nano–bio
interfaces,
hierarchical
structures,
vivo
trajectories.
Then,
accumulation,
internalization,
metabolic
evolution
cellular
environment
as‐imparted
theranostic
functionalization
demonstrated.
The
metabolism
transportation
processes
subsequently
distilled.
Finally,
ends
with
conclusions
perspectives
on
outstanding
issues
NC‐mediated
near
future.
This
expected
provide
inspiration
tailoring
customization
NC‐based
meet
practical
requirements
different
sectors
nanomedicine.
