Effectiveness of Psychobiotics in the Treatment of Psychiatric and Cognitive Disorders: A Systematic Review of Randomized Clinical Trials

Nutrients, Journal Year: 2024, Volume and Issue: 16(9), P. 1352 - 1352

Published: April 30, 2024

In this study, a systematic review of randomized clinical trials conducted from January 2000 to December 2023 was performed examine the efficacy psychobiotics—probiotics beneficial mental health via gut–brain axis—in adults with psychiatric and cognitive disorders. Out 51 studies involving 3353 patients where half received psychobiotics, there notably high measurement effectiveness specifically in treatment depression symptoms. Most participants were older female, treatments commonly utilizing strains Lactobacillus Bifidobacteria over periods ranging 4 24 weeks. Although general agreement on variability approaches presentations limits comparability generalization findings. This underscores need for more personalized optimization deeper investigation into mechanisms through which psychobiotics act. The research corroborates therapeutic potential represents progress management

Language: Английский

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Does the Gut Microbial Metabolome Really Matter? The Connection between GUT Metabolome and Neurological Disorders

Nutrients, Journal Year: 2022, Volume and Issue: 14(19), P. 3967 - 3967

Published: Sept. 24, 2022

Herein we gathered updated knowledge regarding the alterations of gut microbiota (dysbiosis) and its correlation with human neurodegenerative brain-related diseases, e.g., Alzheimer’s Parkinson’s. This review underlines importance gut-derived metabolites metabolic status as main players in gut-brain crosstalk their implications on severity neural conditions. Scientific evidence indicates that administration probiotic bacteria exerts beneficial protective effects reduced systemic inflammation, neuroinflammation, inhibited neurodegeneration. The experimental results performed animals, but also clinical trials, show designing a novel microbiota-based dietary supplementation aim to prevent or ease symptoms Parkinson’s diseases other forms dementia

Language: Английский

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Lacticaseibacillus paracasei PS23 increases ghrelin levels and modulates microbiota composition: a post-hoc analysis of a randomized controlled study

Food & Function, Journal Year: 2024, Volume and Issue: 15(12), P. 6523 - 6535

Published: Jan. 1, 2024

PS23 supplementation raises ghrelin levels and optimizes the gut microbiota, linked to improved exercise outcomes reduced inflammation, promoting muscle recovery.

Language: Английский

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Can We Modulate Our Second Brain and Its Metabolites to Change Our Mood? A Systematic Review on Efficacy, Mechanisms, and Future Directions of “Psychobiotics”

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 1972 - 1972

Published: Feb. 25, 2025

Psychobiotics, live microorganisms that provide mental health by interacting with the gut microbiota, are emerging as a promising therapeutic option for psychiatric and neurodevelopmental disorders. Their effectiveness in addressing conditions such depression, anxiety, insomnia, stress, autism spectrum disorder (ASD), eating disorders were examined through comprehensive analysis of existing studies up to first half 2024, based on data from reliable electronic databases. We found psychobiotics can significantly reduce symptoms various influencing neurotransmitter levels, regulating hypothalamic-pituitary-adrenal (HPA) axis, improving barrier function short-chain fatty acids (SCFAs) other metabolites. However, several limitations identified, including inconsistent study methodologies, small sample sizes, lack long-term safety. Addressing these rigorous research is essential establishing standardized protocols fully confirming potential psychobiotics. In conclusion, show great promise complementary treatments conditions, but continued necessary refine their application integrate them into clinical practice effectively.

Language: Английский

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The Effects of Psychobiotics and Adaptogens on the Human Stress and Anxiety Response: A Systematic Review

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(8), P. 4564 - 4564

Published: April 21, 2025

In recent years, growing interest has emerged in the use of psychobiotics and adaptogens for regulating stress anxiety. However, it is essential to assess their effectiveness as treatment alternatives, particularly given limitations conventional approaches, such adverse effects pharmacological therapies limited remission rates associated with psychotherapy alone. This systematic review primarily aims how effective are alleviating stress- anxiety-related psychophysiological symptoms. A secondary aim identify specific bacterial strains herbal compounds most consistently linked beneficial outcomes. An extensive search was conducted PubMed, Scopus, ScienceDirect, Google Scholar using terms ((adaptogens) OR (psychobiotics)) AND (stress), resulting 23 selected articles. The findings suggest that both show promise reducing Bifidobacterium longum Lactobacillus rhamnosus were frequently improved gut–brain axis regulation, while Withania somnifera Rhodiola rosea demonstrated physiological benefits through cortisol reduction adaptation. Although results encouraging, further research needed confirm long-term efficacy clarify mechanisms responsible these effects.

Language: Английский

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Opportunities for growth in the growing field of psychobiotics

Beneficial Microbes, Journal Year: 2022, Volume and Issue: 13(6), P. 445 - 452

Published: Nov. 15, 2022

There is growing interest in the field of psychobiotics, which are probiotics that confer a mental health benefit when ingested. As this grows, it should pay particular attention to three areas within psychobiotics research currently under-studied – sex (and gender) representation, fungi and mycobiome, vagus nerve activity. Giving these domains more feasible without significant increased investment time or money. We discuss briefly, why they relevance for research, how can easily integrate their perspectives. Our recommendations summarised conclusion, but include equal representation at all phases (human animal studies), investigating relationship between commensal fungi, measuring activity studies.

Language: Английский

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Probiotics, Prebiotics, and Synbiotics: Advanced Nutraceuticals

Published: Jan. 1, 2024

Language: Английский

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Exploring the Promise of Psychobiotics: Bridging Gut Microbiota and Mental Health for a Flourishing Society

Medicine in Microecology, Journal Year: 2024, Volume and Issue: unknown, P. 100118 - 100118

Published: Nov. 1, 2024

Language: Английский

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Early Versus Delayed Oral Feeding after Uncomplicated Cesarean Section

Benha Journal of Applied Sciences, Journal Year: 2023, Volume and Issue: 8(11), P. 25 - 28

Published: Nov. 26, 2023

Background: Cesarean section (CS) is the most common surgery in world and defined as a laparotomy followed by hysterotomy fetal delivery.The current global standard to use regional anesthesia, which allows patients remain awake minimizes drug transfer fetus.Aim objectives: assess safety of early Versus Delayed Oral Feeding after Uncomplicated Section on following post-operative outcomes: vomiting abdominal distention, nausea pain, return intestinal movements, duration intravenous fluid administration, hospital stay.Subjects methods: This randomized controlled trial study was conducted at Benha university hospitals.This 200 consenting women undergoing cesarean section.All were divided into 2 equal groups: receive either or delayed feeding.Results: there high statistical significant differences between both groups regarding secondary postoperative outcomes like time until bowel ambulation, opening, discontinuation fluids (p<0.001).Majority underwent spinal anesthesia (60%, 70% respectively). Conclusion:The showed that improvements function maternal satisfaction, coupled with lack gastrointestinal complications, support advisability oral feeding over late feeding.

Language: Английский

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