Nutrients,
Journal Year:
2024,
Volume and Issue:
16(17), P. 2838 - 2838
Published: Aug. 24, 2024
The
gut
microbiota
constitutes
a
complex
ecosystem,
comprising
trillions
of
microbes
that
have
co-evolved
with
their
host
over
hundreds
millions
years.
Over
the
past
decade,
growing
body
knowledge
has
underscored
intricate
connections
among
diet,
microbiota,
and
human
health.
Bioactive
polysaccharides
(BPs)
from
natural
sources
like
medicinal
plants,
seaweeds,
fungi
diverse
biological
functions
including
antioxidant,
immunoregulatory,
metabolic
activities.
Their
effects
are
closely
tied
to
which
metabolizes
BPs
into
health-influencing
compounds.
Understanding
how
interact
is
critical
for
harnessing
potential
health
benefits.
This
review
provides
an
overview
focusing
on
its
role
in
diseases
obesity,
type
II
diabetes
mellitus,
non-alcoholic
fatty
liver
disease,
cardiovascular
diseases.
It
explores
basic
characteristics
several
impact
microbiota.
Given
significance
health,
we
summarize
these
BPs,
particularly
terms
immunoregulatory
activities,
blood
sugar,
hypolipidemic
effect,
thus
providing
valuable
reference
understanding
benefits
treating
These
properties
make
promising
agents
preventing
comprehensive
mechanisms
by
exert
through
opens
new
avenues
developing
targeted
therapies
improve
Food Bioscience,
Journal Year:
2024,
Volume and Issue:
60, P. 104460 - 104460
Published: May 31, 2024
Non-alcoholic
fatty
liver
disease
(NAFLD)
is
the
hepatic
manifestation
of
metabolic
syndrome
and
one
risk
factors
for
hepatocellular
carcinoma
(HCC).
NAFLD-HCC
a
injury
which
there
lack
effective
treatment.
The
present
study
demonstrates
protective
effects
Ursolic
acid
(UA)
ameliorating
elucidates
underlying
mechanisms.
A
C57BL/6
male
mouse
model
was
fed
high-fat
diet
(HFD)
injected
with
diethylnitrosamine
(DEN)
8
months.
administered
to
HFD+DEN
mice
in
order
elucidate
direct
involvement
UA
pathogenesis
NAFLD-HCC.
Liver
tissue
metabolomics
performed
by
UPLC/Q-TOF-MS.
Results
revealed
that
HFD+DEN-induced
model,
slowed
progressive
development
steatosis,
steatohepatitis,
fibrosis
eventually
HCC
mice.
ameliorates
lipid
accumulation
dysfunction
In
addition,
treatment
effectively
ameliorated
disturbances
endogenous
metabolism
induced
HFD+DEN,
particularly
glycerophospholipid
metabolism.
Close
relationships
were
discovered
between
indexes
differential
metabolites,
LPA
(0:0/16:0),
PE
(20:0/20:4(5Z,8Z,11Z,14Z)),
PC
(15:0/20:2(11Z,14Z)),
LysoPC
(16:1(9Z)).
Moreover,
modified
expression
proteins
mRNA
related
metabolism,
could
be
attributed
synthesis
(FAS)
pathway
activation
oxidation
(FAO)
inhibition.
This
first
time
it
has
been
shown
suppresses
moderating
presents
novel
mechanistic
explanation
amelioration
UA,
thereby
offering
new
insights
into
prevention
this
condition.
Journal of Agricultural and Food Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 15, 2025
The
complex
fatty
acid
(FA)
composition
of
the
edible
portion
American
oysters
(Crassostrea
virginica)
presents
a
significant
analytical
challenge
to
complete
characterization.
Here,
we
employed
solvent-mediated
covalent
adduct
chemical
ionization
enable
comprehensive
de
novo
characterization
its
FA
composition,
with
isotope
ratio
mass
spectrometry
for
initial
measurements
13C
signatures.
Unusual
polymethylene-interrupted
(PMI)
polyunsaturates
were
unequivocally
identified,
22:2(7Z,15Z)
dominating
at
5.5%
(w/w).
In
contrast,
sea
urchins
collected
from
same
area
are
abundant
in
shorter-chain-length
C20
PMI-FA.
Three
even-numbered-chain
anteiso
branched-chain
FAs
(BCFAs),
C14,
C16,
and
C18,
characterized
first
time.
Gulf
contain
1.8%
total
BCFA
23.2%
combined
EPA
DHA.
A
100
g
serving
provides
32.9
mg
BCFA;
140.1
PMI-FA;
426.9
Oysters
origin
exhibit
significantly
different
δ13C
values
most
measured
FA,
indicating
distinct
dietary
origins.
Food Chemistry X,
Journal Year:
2025,
Volume and Issue:
27, P. 102417 - 102417
Published: March 28, 2025
The
dietary
fiber
in
highland
barley
(HB)
may
be
a
key
nutrient
exerting
its
physiological
functions.
How
about
the
effects
of
other
nutrients?
In
this
study,
high-fat
diet
(HFD)-induced
obese
mice
was
constructed
to
investigate
HB
different
nutrients
on
weight
loss.
results
showed
that
peeling
treatment
had
varying
nutrients.
Consumption
significantly
mitigated
gain,
postprandial
blood
glucose
levels,
organ
weight,
adipose
tissue
and
fat
accumulation
mice.
also
ameliorated
hepatic
steatosis,
hyperlipemia,
abnormal
liver
function,
dysregulation
inflammatory
factor
expression
Unpeeled
once
peeled
presented
best
effect.
Furthermore,
consumption
improved
imbalance
gut
microbiota
HFD-induced
mice,
with
protein
being
factors
improvement
This
study
highlights
potential
for
treating
obesity.
