Torreya
grandis
kernel
has
traditionally
been
used
to
remove
intestinal
parasites
and
increases
motility.
However,
the
effect
of
oil
(TKO)
on
constipation
not
yet
investigated.
Therefore,
mouse
model
is
investigate
TKO
slow
transit
(STC)
its
possible
mechanism.
Journal of Functional Foods,
Journal Year:
2023,
Volume and Issue:
112, P. 105966 - 105966
Published: Dec. 19, 2023
Previously,
lactic
acid
bacteria
(LAB)
and
selected
LAB-inoculated
kimchi
(SK)
have
anti-obesity
activity
in
vitro.
Herein,
of
SK
was
investigated
vivo.
LAB-uninoculated
(NK)
were
orally
administered
(70
mg/kg)
for
8
weeks
to
high-fat
diet
(HFD)-fed
mice.
The
body
weight,
food
efficiency
rate
(FER),
composition
measured.
Serum
glutamic
oxaloacetic
transaminase
(GOT),
pyruvic
(GPT),
adipocytokine,
lipid
profiles
accumulation
levels
assessed.
effects
on
microbiome
changes
investigated.
In
groups,
fat,
organ
weight
low
GOT
GPT
significantly
decreased
(p
<
0.05);
serum
adiponectin
leptin
increased
decreased,
respectively.
Kimchi
obesity-related
gene
expression
0.05).
corrected
HFD-induced
gut
imbalance,
notably
with
more
reliable
recovery
the
group.
Its
vivo
confirmed
supports
using
kimchi's
health
functionalities.
Journal of Functional Foods,
Journal Year:
2023,
Volume and Issue:
112, P. 105928 - 105928
Published: Dec. 2, 2023
Pectic
oligosaccharides
have
been
proposed
as
a
novel
prebiotic
to
prevent
obesity
and
associated
with
metabolic
disorders
by
regulating
gut
microbiota,
but
their
various
probiotic
functions
in
the
depended
on
complex
heterogeneous
sugar
composition.
This
study
aimed
obtain
specific
oligogalacturonic
acids
(POAS)
from
pectin
investigate
effects
of
POAS
high-fat
diet-induced
mice.
The
results
showed
that
improved
body
weight
gain,
serum
lipids
hepatic
steatosis
obese
notably
enhanced
intestinal
barrier
function,
reduced
inflammatory
response
regulated
expression
key
genes
lipid
synthesis
metabolism.
Besides,
also
promoted
short-chain
fatty
(SCFAs)
production.
Furthermore,
alleviated
microbiota
dysbiosis
caused
HFD
significantly
increasing
beneficial
such
Akkermansia
Lactobacillus.
Spearman's
correlation
analysis
indicated
these
bacteria
were
strongly
correlated
obesity-related
parameters.
We
conclude
is
potential
treat
related
complications.
The
gut
microbiota
constitutes
a
complex
ecosystem,
comprising
trillions
of
microbes
that
have
co-evolved
with
their
host
over
hundreds
millions
years.
Over
the
past
decade,
growing
body
knowledge
has
underscored
intricate
connections
among
diet,
microbiota,
and
human
health.
Bioactive
polysaccharides
(BPs)
from
natural
sources
like
medicinal
plants,
sea-weeds,
fungi
diverse
biological
functions,
including
antioxidant,
immunoregulatory,
metabolic
activities.
Their
effects
are
closely
tied
to
which
metabolizes
BPs
into
health-influencing
compounds.
Understanding
how
interact
is
critical
for
harnessing
potential
health
benefits.
This
review
provides
an
overview
focusing
on
its
role
in
diseases
obesity,
type
II
diabetes
mellitus
(T2DM),
non-alcoholic
fatty
liver
disease
(NAFLD),
cardiovascular
(CVD).
It
explores
basic
characteristics
several
impact
microbiota.
Given
significance
health,
we
summarize
functions
these
BPs,
particularly
terms
im-munoregulatory
activities,
blood
sugar,
hypolipidemic
effect,
providing
valuable
reference
understanding
benefits
treating
diseases.
These
properties
make
promising
agents
preventing
comprehensive
mechanisms
by
exert
through
opens
new
avenues
developing
targeted
therapies
improve
