Light‐Responsive Materials in Droplet Manipulation for Biochemical Applications

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 21, 2024

Miniaturized droplets, characterized by well-controlled microenvironments and capability for parallel processing, have significantly advanced the studies on enzymatic evolution, molecular diagnostics, single-cell analysis. However, manipulation of small-sized including moving, merging, trapping targeted droplets complex biochemical assays subsequent analysis, is not trivial remains technically demanding. Among various techniques, light-driven methods stand out as a promising candidate droplet in facile flexible manner, given features contactless interaction, high spatiotemporal resolution, biocompatibility. This review therefore compiles an in-depth discussion governing mechanisms underpinning manipulation. Besides, light-responsive materials, representing core light-matter interaction key character converting light into different forms energy, are particularly assessed this review. Recent advancements materials most notable applications comprehensively archived evaluated. Continuous innovations rational engineering expected to propel development manipulation, equip with enhanced functionality, broaden routine investigations.

Language: Английский

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Epidemiology and diagnosis technologies of human metapneumovirus in China: a mini review

Virology Journal, Journal Year: 2024, Volume and Issue: 21(1)

Published: March 7, 2024

Abstract Human metapneumovirus (HMPV) is a newly identified pathogen causing acute respiratory tract infections in young infants worldwide. Since the initial document of HMPV infection China 2003, Chinese scientists have made lots efforts to prevent and control this disease, including developing diagnosis methods, vaccines antiviral agents against HMPV, as well conducting epidemiological investigations. However, effective or special are currently not approved, thus early methods knowing its characteristics will be beneficial for control. Here, we summarized current research focused on available detection which increase public awareness disease future.

Language: Английский

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Advanced design and applications of digital microfluidics in biomedical fields: An update of recent progress

Biosensors and Bioelectronics, Journal Year: 2023, Volume and Issue: 242, P. 115723 - 115723

Published: Oct. 1, 2023

Language: Английский

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Advances in Directional Wetting Surfaces for Enhanced Fluid Control: A Comprehensive Review

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(9)

Published: Nov. 27, 2023

Abstract Controlling surface wettability and directing the flow of working fluids have crucial implications in various natural engineering contexts. Understanding fundamental principles directional wetting is essential for effectively leveraging these phenomena to enhance performance systems, such as microfluidics or heat exchangers. This comprehensive review summarizes previous research, emphasizing recent advances by categorizing structures associated with surfaces. The efforts researchers who employed diverse strategies manipulate behavior liquids through both passive active control mechanisms are highlighted. Passive transport surfaces require no additional energy while enabling large‐scale continuous fluid control. Conversely, offer enhanced flexibility precise liquid movement. Furthermore, insights into studies that focused on practical applications provided current challenges need be addressed discussed. study serves a guide future research directions development offers valuable recommendations implementation.

Language: Английский

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Microfluidic programmable strategies for channels and flow

Lab on a Chip, Journal Year: 2024, Volume and Issue: 24(19), P. 4483 - 4513

Published: Jan. 1, 2024

This review summarizes programmable microfluidics, an advanced method for precise fluid control in microfluidic technology through microchannel design or liquid properties, referring to microvalves, micropumps, digital multiplexers, micromixers, slip-, and block-based configurations. Different microvalve types, including electrokinetic, hydraulic/pneumatic, pinch, phase-change check valves, cater diverse experimental needs. Programmable such as passive active play a crucial role achieving automation. Due their small size high integration, microvalves micropumps are widely used medical devices biological analysis. In addition, this provides in-depth exploration of the applications multiplexed mixer-based microfluidics manipulation movement, mixing, splitting. These methodologies leverage physical properties liquids, capillary forces dielectric forces, achieve over dynamics. SlipChip technology, which branches into rotational translational SlipChip, controls sliding motion microchannel. On other hand, innovative designs systems pursue better modularity, reconfigurability ease assembly. assembly strategies, from one-dimensional blocks two-dimensional Lego®-style three-dimensional reconfigurable modules, aim enhance flexibility accessibility. technologies user-friendliness accessibility by offering integrated systems, making them potentially usable outside specialized technical labs. Microfluidic strategies channels flow hold promising biomedical research, chemical analysis drug screening, providing theoretical practical guidance broader utilization scientific research applications.

Language: Английский

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Artificial intelligence-enabled multipurpose smart detection in active-matrix electrowetting-on-dielectric digital microfluidics

Microsystems & Nanoengineering, Journal Year: 2024, Volume and Issue: 10(1)

Published: Sept. 27, 2024

Language: Английский

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Smartphones as a platform for molecular analysis: concepts, methods, devices and future potential

Lab on a Chip, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Smartphones have the potential to transform chemical and biological analysis by functioning as portable, versatile, democratized platforms for molecular diagnostics. Recent advances in optical detection devices are reviewed.

Language: Английский

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Emerging microfluidic technologies for CRISPR-based diagnostics: an overview

Analytical Methods, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This review explores emerging CRISPR-microfluidic platforms enhancing precision, speed, and portability for point-of-care diagnostics. Innovations like SHINE, CARMEN, ITP, DNAiTECH, Dμchip, FAST, MAPnavi highlight their potential.

Language: Английский

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Enhancing safety in small confined spaces with thermally triggered fire-extinguishing microcapsules from microfluidics

Lab on a Chip, Journal Year: 2024, Volume and Issue: 24(4), P. 904 - 912

Published: Jan. 1, 2024

The microfluidic technique encapsulates perfluorohexanone for rapid fire extinguishing. Microcapsules quench flames larger than their size, extendable to two-dimensional patches, preventing spread.

Language: Английский

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Demystifying EV heterogeneity: emerging microfluidic technologies for isolation and multiplexed profiling of extracellular vesicles

Lab on a Chip, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The microfluidic-based technique that combines efficient isolation of EVs and multiple detection EV cargos like proteins, nucleic acids, glycans at bulk, single/single cell level to further demystify heterogeneity.

Language: Английский

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