Journal of Functional Biomaterials,
Journal Year:
2024,
Volume and Issue:
15(8), P. 225 - 225
Published: Aug. 14, 2024
The
intersection
of
immunology
and
nanotechnology
has
provided
significant
advancements
in
biomedical
research
clinical
applications
over
the
years.
Immunology
aims
to
understand
immune
system’s
defense
mechanisms
against
pathogens.
Nanotechnology
demonstrated
its
potential
manipulate
responses,
as
nanomaterials’
properties
can
be
modified
for
desired
application.
Research
shown
that
nanomaterials
applied
diagnostics,
therapy,
vaccine
development.
In
used
biosensor
development,
accurately
detecting
biomarkers
even
at
very
low
concentrations.
Therapeutically,
act
efficient
carriers
delivering
drugs,
antigens,
or
genetic
material
directly
targeted
cells
tissues.
This
delivery
improves
therapeutic
efficacy
reduces
adverse
effects
on
healthy
nanoparticles
improve
durability
extend
responses
by
effectively
adjuvants
antigens
cells.
Despite
these
advancements,
challenges
regarding
safety,
biocompatibility,
scalability
are
still
present.
review
will
cover
fundamental
interactions
between
system,
their
immunology,
safety
biocompatibility
concerns.
Nanomedicine,
Journal Year:
2024,
Volume and Issue:
19(11), P. 995 - 1012
Published: April 9, 2024
Aim:
To
investigate
the
influence
of
fluorine
in
reducing
adsorption
immune-reactive
proteins
onto
PEGylated
gold
nanoparticles.
Methods:
Reversible
addition
fragmentation
chain
transfer
polymerization,
Turkevich
method
and
ligand
exchange
were
used
to
prepare
polymer-coated
Subsequent
vitro
physicochemical
biological
characterizations
proteomic
analysis
performed.
Results:
Fluorine-modified
polymers
reduced
complement
other
while
potentially
improving
circulatory
times
modulating
liver
toxicity
by
apolipoprotein
E
adsorption.
Fluorine
actively
discouraged
phagocytosis
encouraging
therapeutic
targets,
CD209
signaling
molecule
calreticulin.
Conclusion:
This
study
suggests
that
surface
coating
nanoparticles
could
lead
improved
performance
nanomedicine
designed
for
intravenous
delivery
cargos.
Biocatalysis and Agricultural Biotechnology,
Journal Year:
2024,
Volume and Issue:
58, P. 103223 - 103223
Published: May 11, 2024
Exploring
secondary
outputs,
specifically
leftover
materials
from
steam
distillation
of
Rosmarinus
tournefortii
de
Noé,
as
agents
for
reducing
metals
introduces
a
novel
approach
to
eco-friendly
nanomaterial
production.
This
concept
aligns
with
the
creation
environmentally
conscious
nanoparticles,
showcasing
potential
across
various
fields,
notably
biomedicine.
The
paper
seamlessly
fits
into
this
context.
By
utilizing
R.
successful
synthesis
silver
nanoparticles
(AgNPs)
was
achieved,
yielding
nanoscale
variations
influenced
by
plant's
by-products.
Beyond
structural
aspects,
investigating
biomedical
applications,
focusing
on
antioxidant
and
antimicrobial
properties.
Consistently
observing
∼94.9–97.3%
scavenging
inhibition
in
water
residues
at
different
concentrations
enhanced
efficacy
against
Gram-negative
Gram-positive
bacteria
Rhodotorula
glutinis
yeast
due
these
residues.
Moreover,
thorough
examination
using
density
functional
theory
unveiled
robust
interaction
between
clusters
specific
biomolecules
found
within
residues,
namely
homoplantaginin,
protocatechuic
acid-glycoside,
caffeic,
rosmarinic
acids
(ranging
130.62
357.05
kcal/mol).
These
compounds
enhance
Ag+
ions
contribute
enduring
stability
AgNPs
(ζ
values:
-22.8
mV
-17.2
mV).
Furthermore,
study
recognizes
challenges
finding
alternative
surface
modification
explores
intricate
toxicity
mechanisms
emphasizing
their
interactions
inflammation.
Introducing
promising
nanomedicine
approaches
involving
acid
inflammatory
bowel
disease
rheumatoid
arthritis,
highlighting
rosemary
by-products
derived
innovative
therapeutic
interventions
diverse
conditions.
