Nanomaterial assisted natural killer cell therapy DOI Creative Commons

Xuan Yu,

Xiaobo Chen, Yuhua Yang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 5, 2025

The rising incidence of cancer has heightened interest in immune cell therapy, particularly the role natural killer (NK) cells, which are essential components system. Their applications tumor treatment have expanded significantly, especially with incorporation nanomaterials. This review comprehensively examines NK biology, encompassing aspects such as classification, distribution, receptor activation, and mechanisms cytotoxicity. It also explores various therapies, including their sources, methods acquisition, expansion techniques, Chimeric antigen receptor-Natural Killer (CAR-NK) technology, gene editing strategies, combination therapies. Additionally, discusses utilization nanomaterials focusing on nanoparticle-assisted regulation modulation microenvironment. While therapy holds promise, CAR-NK technology presents certain limitations. integration offers potential strategies to enhance therapeutic efficacy. Future research should prioritize optimization address limitations associated investigate nanomaterials, develop more effective improve clinical outcomes.

Language: Английский

Novel Strategies for Preventing Fungal Infections—Outline DOI Creative Commons

Damilola Janet Agbadamashi,

Claire Price

Pathogens, Journal Year: 2025, Volume and Issue: 14(2), P. 126 - 126

Published: Feb. 1, 2025

Fungal infections are a significant global health challenge, causing approximately 3.8 million deaths annually, with immunocompromised populations particularly at risk. Traditional antifungal therapies, including azoles, echinocandins, and polyenes, face limitations due to rising resistance, toxicity, inadequate treatment options. This review explores innovative strategies for preventing managing fungal infections, such as vaccines, peptides, nanotechnology, probiotics, immunotherapy. Vaccines offer promising avenues long-term protection, despite difficulties in their development complexity immune evasion mechanisms. Antifungal peptides provide novel class of agents broad-spectrum activity reduced resistance risk, whilst nanotechnology enables targeted, effective drug delivery systems. Probiotics show potential vulvovaginal candidiasis, by maintaining microbial balance. Immunotherapy leverages system modulation enhance defenses, omics technologies deliver comprehensive insights into biology, paving the way therapeutic vaccine targets. While these approaches hold immense promise, challenges cost, accessibility, translational barriers remain. A coordinated effort among researchers, clinicians, policymakers is critical advancing addressing burden effectively.

Language: Английский

Citations

3
Nanostructured Drug Delivery Systems in Immunotherapy: An Updated Overview of Nanotechnology-Based Therapeutic Innovations DOI Creative Commons

George-Alexandru Croitoru,

Adelina-Gabriela Niculescu,

Dragoș Epistatu

et al.

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(19), P. 8948 - 8948

Published: Oct. 4, 2024

Using nanostructured drug delivery systems has attracted increasing interest in immunotherapeutic approaches. The intrinsic immunomodulatory properties and versatility of nanoparticles used as carriers were consistently reported to augment treatment efficiency nanoscaled materials increase accumulation at the desired site, enhance cell internalization, improve therapeutic outcomes. Thus, numerous studies have exploited potential use vehicles delivering different cargo a promising alternative for treating conditions like cancer, autoimmune diseases, infectious allergic immune disorders. In this context, paper presents solid basis innovations, highlighting their advantages improving strategies, reviewing clinical applications, discussing existing challenges ways overcome them.

Language: Английский

Citations

9
Application and Safety Research of Nanotechnology in Cosmetics: Current Status, Challenges, and Future Prospects DOI
Xuexue Pan,

Huiru Zhou,

Zhirui Li

et al.

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(2)

Published: March 22, 2025

Language: Английский

Citations

1
Development and application of novel biosensors for enhanced detection in medical diagnostics DOI
A.M. Elbasiony, Sarah Alharthi, Mohamed Mohamady Ghobashy

et al.

Microchemical Journal, Journal Year: 2024, Volume and Issue: unknown, P. 111938 - 111938

Published: Oct. 1, 2024

Language: Английский

Citations

6
Recent advances in DNA nanotechnology for cancer detection and therapy: A review DOI

Donya Esmaeilpour,

Matineh Ghomi, Ehsan Nazarzadeh Zare‬

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142136 - 142136

Published: March 1, 2025

Language: Английский

Citations

0
Advancing Precision Medicine: Uncovering Biomarkers and Strategies to Mitigate Immune-Related Adverse Events in Immune Checkpoint Inhibitors Therapy DOI Creative Commons

K L Nityashree,

P. Rachitha,

Shilpa Hanchinmane

et al.

Toxicology Reports, Journal Year: 2025, Volume and Issue: unknown, P. 102035 - 102035

Published: April 1, 2025

Language: Английский

Citations

0
A cell wall-targeting urease-derived peptide as a potential antifungal agent against Candida species DOI Creative Commons
Ana Paula A. Perin, Júlia Catarina Vieira Reuwsaat, Heryk Motta

et al.

Current Research in Microbial Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 100399 - 100399

Published: May 1, 2025

Language: Английский

Citations

0
Nanomaterial assisted natural killer cell therapy DOI Creative Commons

Xuan Yu,

Xiaobo Chen, Yuhua Yang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 5, 2025

The rising incidence of cancer has heightened interest in immune cell therapy, particularly the role natural killer (NK) cells, which are essential components system. Their applications tumor treatment have expanded significantly, especially with incorporation nanomaterials. This review comprehensively examines NK biology, encompassing aspects such as classification, distribution, receptor activation, and mechanisms cytotoxicity. It also explores various therapies, including their sources, methods acquisition, expansion techniques, Chimeric antigen receptor-Natural Killer (CAR-NK) technology, gene editing strategies, combination therapies. Additionally, discusses utilization nanomaterials focusing on nanoparticle-assisted regulation modulation microenvironment. While therapy holds promise, CAR-NK technology presents certain limitations. integration offers potential strategies to enhance therapeutic efficacy. Future research should prioritize optimization address limitations associated investigate nanomaterials, develop more effective improve clinical outcomes.

Language: Английский

Citations

0