Therapeutic Delivery, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11
Published: Jan. 28, 2025
Aim The study aimed to formulate solid lipid nanoparticles (SLNs) for the transdermal delivery of PPL improve skin retention and efficacy.
Language: Английский
Life Sciences, Journal Year: 2024, Volume and Issue: 346, P. 122616 - 122616
Published: April 8, 2024
Language: Английский
Citations
22
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 21, 2025
Nucleic acid therapeutics represent a highly promising treatment approach in modern medicine, treating diseases at the genetic level. However, these face numerous challenges practical applications, particularly regarding their stability, effectiveness, cellular uptake efficiency, and limitations delivering them specifically to target tissues. To overcome obstacles, researchers have developed various innovative delivery systems, including viral vectors, lipid nanoparticles, polymer inorganic protein carriers, exosomes, antibody oligonucleotide conjugates, DNA nanostructure-based systems. These systems enhance therapeutic efficacy of nucleic drugs by improving targeting specificity, half-life vivo. In this review, we systematically discuss different types drugs, analyze major barriers encountered delivery, summarize current research progress emerging We also highlight latest advancements application for diseases, infectious cancer, brain wound healing. This review aims provide comprehensive overview drug systems' status future directions integrating nanotechnology, biomaterials science, gene editing technologies, emphasizing transformative potential precision medicine.
Language: Английский
Citations
2
Molecules, Journal Year: 2023, Volume and Issue: 28(15), P. 5905 - 5905
Published: Aug. 5, 2023
Cancer is a progressive disease of multi-factorial origin that has risen worldwide, probably due to changes in lifestyle, food intake, and environmental as some the reasons. Skin cancer can be classified into melanomas from melanocytes nonmelanoma skin (NMSC) epidermally-derived cell. Together it constitutes about 95% cancer. Basal cell carcinoma (BCC) cutaneous squamous (CSCC) are creditworthy 99% NMSC limited accessibility conventional formulations cells having multiple obstacles treatment reply this therapeutic regime. Despite this, often encounters erratic bioavailability absorption target. Nanoparticles developed through nanotechnology platforms could better topical therapy option. To improve delivery, nano-sized delivery system appropriate fuses with layer fluidized membrane; thus, deeper penetration therapeutics possible reach target spot. This review briefly outlooks various nanoparticle preparations, i.e., liposomes, niosomes, ethosomes, transferosomes, transethosomes, nanoemulsions, nanoparticles technologies tested impede their progress tend concentrate layers. Nanocarriers have proved they considerably boost medication bioavailability, lowering frequency dosage reducing toxicity associated high doses medication.
Language: Английский
Citations
28
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(4), P. 449 - 449
Published: March 25, 2024
Psoriasis (PSO) is a chronic autoimmune skin condition characterized by the rapid and excessive growth of cells, which leads to formation thick, red, scaly patches on surface skin. These can be itchy painful, they may cause discomfort for patients affected this condition. Therapies psoriasis aim alleviate symptoms, reduce inflammation, slow down cell growth. Conventional topical treatment options are non-specific, have low efficacy associated with adverse effects, why researchers investigating different delivery mechanisms. A novel approach drug using nanoparticles (NPs) shows promise in reducing toxicity improving therapeutic efficacy. The unique properties NPs, such as their small size large area, make them attractive targeted delivery, enhanced stability, controlled release. In context PSO, NPs designed deliver active ingredients anti-inflammatory effect, immunosuppressants, or other compounds directly areas. formulations offer improved access epidermis facilitate better absorption, thus enhancing conventional anti-psoriatic drugs. increase surface-to-volume ratio, resulting penetration through skin, including intracellular, intercellular, trans-appendage routes. present review aims discuss latest approaches therapy PSO NPs. It intended summarize results vitro vivo examinations carried out last few years regarding effectiveness safety nanoparticles.
Language: Английский
Citations
13
Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(16), P. 3807 - 3839
Published: Jan. 1, 2024
This review article explores the innovative field of eco-friendly cyclodextrin-based coordination polymers and metal-organic frameworks (MOFs) for transdermal drug delivery in case skin cancer therapy. We critically examine significant advancements developing these nanocarriers, with a focus on their unique properties such as biocompatibility, targeted release, enhanced permeability. These attributes are instrumental addressing limitations inherent traditional treatments represent paradigm shift towards more effective patient-friendly therapeutic approaches. Furthermore, we discuss challenges faced optimizing synthesis process large-scale production while ensuring environmental sustainability. The also emphasizes immense potential clinical applications nanocarriers therapy, highlighting role facilitating targeted, controlled release which minimizes systemic side effects. Future could see being customized to individual patient profiles, potentially revolutionizing personalized medicine oncology. With further research trials, hold promise transforming landscape treatment. this study, aim provide comprehensive overview current state outline future directions advancing development application nanocarriers.
Language: Английский
Citations
11
Drug Delivery, Journal Year: 2024, Volume and Issue: 31(1)
Published: Jan. 19, 2024
Transdermal drug delivery systems (TDDS) for antibiotics have seen significant advances in recent years that aimed to improve the efficacy and safety of these drugs. TDDS offer many advantages over other conventional such as non-invasiveness, controlled-release pattern, avoidance first-pass metabolism. The objective this review is provide an overview on different groups including β-lactams, tetracyclines, macrolides, lincosamides, utilized their effective through skin explore challenges associated with field. majority do not favorable properties passive transdermal delivery. Thus, novel strategies been employed skin, use nanotechnology (nanoparticles, solid-lipid nanoparticles, nanoemulsions, vesicular carriers, liposomes) or physical enhancement techniques like microneedles ultrasound. In conclusion, could be a promising method delivering potential patient outcomes enhance Further research development are still needed more antibiotic drugs by using various approaches.
Language: Английский
Citations
9
Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 92, P. 105395 - 105395
Published: Jan. 23, 2024
Language: Английский
Citations
9
Redox Biology, Journal Year: 2024, Volume and Issue: 70, P. 103055 - 103055
Published: Jan. 23, 2024
Nanozymes with superior antioxidant properties offer new hope for treating oxidative stress-related inflammatory skin diseases. However, lacking sufficient catalytic activity or having complex material designs limit the application of current metallic nanozymes in Here, we report a simple and effective twin-defect platinum nanowires (Pt NWs) enzyme multiple mimetic enzymes broad-spectrum ROS scavenging capability treatment diseases mice (including psoriasis rosacea). Pt NWs simultaneous superoxide dismutase, glutathione peroxidase catalase exhibit cytoprotective effects against ROS-mediated damage at extremely low doses significantly improve outcomes psoriasis- rosacea-like mice. Meanwhile, these ultrasmall sizes allow nanomaterials to effectively penetrate do not produce significant biotoxicity. Therefore, have potential applications related stress inflammation.
Language: Английский
Citations
9
Journal of Biomedical Materials Research Part B Applied Biomaterials, Journal Year: 2025, Volume and Issue: 113(1)
Published: Jan. 1, 2025
A new method is developed using elastic lipid nanovesicles (ELNs) loaded with ethanolic extract of Lantana camara (LC) to enhance skin permeation plant actives. The ELNs contained cholesterol, 1, 2-distearoyl-sn-glycero-3-phosphocholine, span 80, and tween 80. Firstly, 15 formulations were produced examine critical factors likely affecting formulation characteristics. In addition, surface characteristics, vesicle size, polydispersity index, zeta potential, degree deformability, % entrapment efficiency (% EE) ELN examined. As a significant parameter, was measured (using Start-M; it highly resembles human skin). influence hydrophilic-lipophilic balance (HLB), ratio vital through Start-M. particular, the LC decreased at more extensive size ranges, 400, 350-450 nm. contrast, increased significantly smaller such as 200 100 More than 75% permeated within 8 h when surfactant (span 80:tween 80; 25%:75%). Permeation studies conducted based on HLB values revealed that 78% in 12.2, an increase HLB. Cell viability assay SK-MEL-37 cells (skin cancer) reduced by ~80% 24 h, further validating formulation. Future research could investigate long-term safety therapeutic potential these clinical settings their effectiveness delivering other plant-based extracts for transdermal applications via ELNs.
Language: Английский
Citations
1
AAPS PharmSciTech, Journal Year: 2025, Volume and Issue: 26(1)
Published: Jan. 10, 2025
Abstract Continuously explored in pharmaceuticals, microemulsions and nanoemulsions offer drug delivery opportunities that are too significant to ignore, namely safe of clinically relevant doses across biological membranes. Their effectiveness as vehicles mucosal (trans)dermal is evident from the volume published literature. Commonly, their ability enhance skin permeation attributed dispersion size, a characteristic closely related solubilization capacity. However, literature falls short on distinctions between for definitions, behavior, or specific differences mechanisms action delivery. The focus typically surfactant/cosurfactant ratio droplet size but role mesostructures effect cosolvent (C sol ), oil (O) water (W) profile remain poorly explained. Towards deeper understanding these delivery, this review begins with conceptual practical before delving into works less obvious potentially important underlying mechanisms; notably composition competitive positioning system constituents resulting microstructures subsequent effect(s) may have structures permeability. For purposes, focuses formulation systems based ternary diagrams commonly accepted non-ionic surfactants, cosurfactants, cosolvents, oils used pharmaceutical applications. Graphical
Language: Английский
Citations
1