Asprecosides A–J, ten new pentacyclic triterpenoid glycosides with cytotoxic activity from the roots of Ilex asprella DOI Creative Commons

Yuwei Wu,

Baihui Zhang, Wenxian Li

et al.

Natural Products and Bioprospecting, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 13, 2025

Abstract Phytochemical study of the n -BuOH extract Ilex asprella resulted in discovery ten new pentacyclic triterpenoid glycosides, comprising nine ursane-type glycosides ( 1 − 9 ) and one oleanane-type glycoside 10 ), along with seven known compounds 11 17 ). Compound is first reported 19,22-epoxy ursane glycoside, whereas 4 5 are rare examples containing a 28,19-lactone group. The structural characterization these was achieved using spectroscopic chemical techniques, as well single-crystal X-ray analysis. Compounds 7 , 12 15 exhibited moderate cytotoxic activities against H1975 HCC827 cancer cells. Graphical abstract

Language: Английский

Triterpene acids from Rosa roxburghii Tratt fruits exert anti-hepatocellular carcinoma activity via ROS/JNK signaling pathway-mediated cell cycle arrest and mitochondrial apoptosis DOI
Bo-Wen Zhai,

Heng Zhao,

Han-Lin Zhu

et al.

Phytomedicine, Journal Year: 2023, Volume and Issue: 119, P. 154960 - 154960

Published: July 8, 2023

Language: Английский

Citations

12
Monophthalates of betulinic acid and related pentacyclic triterpenes inhibit efficiently the SOS-mediated nucleotide exchange and impact PI3K/AKT signaling in oncogenic K-RAS4B proteins DOI Creative Commons
Gerrit E. Benary,

Frank Kilgenstein,

Sascha Koller

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(2), P. 883 - 895

Published: Jan. 1, 2025

36436308255New derivatives of betulinic, ursolic, and oleanolic acid inhibit GDP/GTP exchange at low micromolar levels act as a molecular glue that stabilizes an unproductive K-RAS4B allo :SOS complex.

Language: Английский

Citations

0
Ternary composite nanoparticles to improve the water solubility and stability of resveratrol:Preparation, characterization and bioavailability DOI
Zhili Wang, Shiyao Fu, Ying Han

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: 474, P. 143258 - 143258

Published: Feb. 6, 2025

Language: Английский

Citations

0
A new Clonostachys sp. ZBS49 filamentous fungus with high production of betulinic acid and its inhibitory effect on liver cancer cells DOI Creative Commons
Li Geng,

Jiale Cui,

Changyixin Xiao

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Abstract Background Triterpenoid compounds such as betulinic acid (BA) and oleanolic (OA) exhibit considerable pharmacological activities. However, their current production primarily relies on plant extraction chemical synthesis, methods that are often plagued by low efficiency, complex processes, environmental concerns. Microbial-based synthesis has emerged one of the most effective approaches for producing BA OA. Results This study presented first identification filamentous fungal strains efficiently synthesizing both The strain ZBS49 is a newly identified species Clonostachys isolated from Gleditsia japonica Miq. (showing 99.82% sequence identity), produced 47.7 mg/L BA. XJ1-1, characterized Colletotrichum gloeosporioides Cannabis sativa L., yielded 65.76 After optimizing culture medium cultivation conditions, yields XJ1-1 increased to 288.97 86.14 mg/L, representing improvements 506% 31%, respectively. Furthermore, we discovered extract significantly inhibited hepatocellular cancer cells (SMMC-7721 HepG2) in dose-dependent manner, with minimum inhibitory concentration 70 µM. Genomic analysis sp. elucidated presence 16 putative genes was related triterpenoid biosynthesis 6 distinct terpene biosynthetic gene clusters. Among 145 CYP450, 5 involved C-28 oxidation were predicted. Conclusions research underscores effectiveness fungi biotechnological platform efficient its derivatives, highlighting potential applications therapy. these findings provide valuable genetic resources establish robust technical theoretical framework utilizing microbial triterpenoids.

Language: Английский

Citations

0
Asprecosides A–J, ten new pentacyclic triterpenoid glycosides with cytotoxic activity from the roots of Ilex asprella DOI Creative Commons

Yuwei Wu,

Baihui Zhang, Wenxian Li

et al.

Natural Products and Bioprospecting, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 13, 2025

Abstract Phytochemical study of the n -BuOH extract Ilex asprella resulted in discovery ten new pentacyclic triterpenoid glycosides, comprising nine ursane-type glycosides ( 1 − 9 ) and one oleanane-type glycoside 10 ), along with seven known compounds 11 17 ). Compound is first reported 19,22-epoxy ursane glycoside, whereas 4 5 are rare examples containing a 28,19-lactone group. The structural characterization these was achieved using spectroscopic chemical techniques, as well single-crystal X-ray analysis. Compounds 7 , 12 15 exhibited moderate cytotoxic activities against H1975 HCC827 cancer cells. Graphical abstract

Language: Английский

Citations

0