Organic Letters,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 9, 2024
An
unexpected
cascade
reaction
of
enyne-amides
with
sulfur-ylides
has
been
developed.
This
involves
cycloisomerization,
dearomatic
cyclopropanation,
ring-opening
rearomatization,
and
subsequent
differing
from
the
common
[2
+
n]
cyclization
enyne-amides.
A
variety
(spirocyclopropane)dihydrofuran
derivatives
have
efficiently
conveniently
synthesized
in
a
single
vessel,
exhibiting
excellent
diastereoselectivity
good
functional
group
tolerance.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(4), P. 581 - 586
Published: Jan. 25, 2023
A
practical
electrochemically
driven
method
for
fluorosulfonylation
of
both
aryl
and
alkyl
thianthrenium
salts
has
been
disclosed.
The
strategy
does
not
need
external
redox
reagents
or
metal
catalysts.
In
combination
with
C-H
thianthrenation
aromatics,
this
provides
a
new
tool
the
site-selective
drugs.
Organic Chemistry Frontiers,
Journal Year:
2023,
Volume and Issue:
10(6), P. 1521 - 1526
Published: Jan. 1, 2023
A
highly
efficient
[4
+
1]
annulation
of
sulfur
ylide
salts
and
o
-sulfonamido
aldimines
for
construction
valuable
2,3-disubstituted
indolines
is
reported.
It
worth
noting
that
indoles
could
also
be
synthesized
by
this
cascade
reaction.
Organic Chemistry Frontiers,
Journal Year:
2023,
Volume and Issue:
10(13), P. 3347 - 3352
Published: Jan. 1, 2023
A
variety
of
enantioenriched
spirofuro[2,3-
b
]azepine-5,3’-indoline
derivatives
were
synthesized
via
Au(I)/chiral
NHC
relay
catalyzed
cycloisomerization/asymmetric
[4+3]
annulation.
Journal of Heterocyclic Chemistry,
Journal Year:
2023,
Volume and Issue:
61(1), P. 29 - 70
Published: Oct. 26, 2023
Abstract
Sulfur
ylides
are
versatile
structures
that
display
various
characteristics
and
participate
in
a
myriad
of
reactions
to
produce
simple,
effective,
sometimes
stereoselective
toward
synthesizing
sulfur‐containing
compounds.
Nonetheless,
their
fulfillment
tremendous
developments
have
been
made
this
field
the
past
few
decades.
In
comprehensive
review,
luminosity
is
illuminated
on
application
sulfur
involved
domino,
cascade
annulation
reactions,
carbene
trapping
reagents
with
chameleonic
reactivity.
numerous
decennary,
chemists
used
solvent‐dependent,
rhodium
catalyzed,
dealkylative
intercepted,
photochemical
reaction,
halotrifluoromethylation,
benzannulation,
amidation
name
such
as
Mizoroki–Heck,
Suzuki–Miyaura,
Sommelet–Hauser
rearrangements.
Moreover,
other
prime
applications
include
metal
catalysis,
epoxidation
carbonyl
compounds,
acylmethylation,
cyclomerization,
oxidation,
insertion
reactions.
Additionally,
some
extremely
useful
play
major
role
synthesis
medicinally
active
heterocycles
structural
motifs.
This
review
article
discusses
all
these
proposed
mechanisms,
current
scenario,
at
length.
tutorial
concludes
by
providing
future
outlook
investigation
into
compounds
synthesized
using
it
great
potential
be
industries,
laboratories,
pharmaceutical
companies,
drug
production,
clinical
use,
medicinal
chemistry,
agrochemical
purposes.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(20), P. 5731 - 5740
Published: Jan. 1, 2024
A
simple
and
practical
method
for
the
synthesis
of
S
-alkyl
phosphorothioates/phosphorodithioates
through
three-component
reaction
cyclic
sulfonium
salts
with
8
,
H
-phosphonates,
or
P
4
10
alcohols
was
readily
developed.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(11), P. 6704 - 6715
Published: May 8, 2023
A
variety
of
4,5-dihydrofuro[2,3-b]azocin-6-one
derivatives
were
expediently
assembled
through
Au(I)-catalyzed
cyclization
and
2-(tert-butyl)-1,1,3,3-tetramethylguanidine
(BTMG)-mediated
[4+4]
annulation
reactions
enyne-amides
ynones.
The
exhibit
high
efficiency
with
excellent
regio-
diastereoselectivity.
broad
spectrum
substrates
was
utilized.
products
an
eight-membered
ring
might
be
useful
in
biological
chemistry
medicinal
science.
Furthermore,
the
could
facilely
converted
into
various
derivatives.
Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
22(11), P. 2197 - 2202
Published: Jan. 1, 2024
A
substrate-directed
divergent
[2+3]/[2+1]
annulation
of
tetra-substituted
oxa-dienes
and
allylic
sulfur
ylides
has
been
developed
for
the
synthesis
functionalized
bispirocyclopentane
bispirocyclopropane
derivatives.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(34), P. 4537 - 4540
Published: Jan. 1, 2024
A
novel
method
was
devised
for
regioselective
ring
expansion
of
spirocyclopropanes
to
spirocyclobutanes
with
stabilized
sulfonium
ylides,
affording
1,2-
trans
-disubstituted
6,8-dioxaspiro[3.5]nonane-5,9-diones
without
the
formation
any
isomers.
