Chemical Communications, Journal Year: 2024, Volume and Issue: 60(57), P. 7351 - 7354
Published: Jan. 1, 2024
Cp 2 Fe-mediated electrochemical synthesis of a diverse array phosphorylated azaspiro[4.5]di/trienones has been developed, which demonstrated broad substrate scope and good diastereoselectivity.
Language: Английский
Chemistry - An Asian Journal, Journal Year: 2023, Volume and Issue: 18(9)
Published: March 15, 2023
Electrochemical dearomative spirocyclization serves as a green and sustainable approach to convert the flat, two-dimension aromatic feedstock into value-added three-dimension spirocyclic architectures. This review highlights recent advances, emphasizes mechanistic discussions, showcases synthetic applications of this emerging versatile powerful transformation.
Language: Английский
Citations
36
Chemical Science, Journal Year: 2024, Volume and Issue: 15(8), P. 2827 - 2832
Published: Jan. 1, 2024
Efficient control over several possible reaction pathways of free radicals is the chemical basis their highly selective transformations. Among various competing pathways, sulfonimidyl generated from electrolysis 2-alkynylbenzenesulfonamides undergo cascade migratory or
Language: Английский
Citations
7
Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(20), P. 5813 - 5819
Published: Jan. 1, 2024
In this paper, we have developed an efficient strategy for the concise synthesis of diverse selenyl imidazo[2,1- b ]thiazinones via electrochemical oxidative three-component tandem reactions in absence transition metals, and oxidants.
Language: Английский
Citations
4
Synthesis, Journal Year: 2023, Volume and Issue: 55(18), P. 2873 - 2895
Published: Jan. 24, 2023
Abstract Spirocyclic compounds have attracted the interest of synthetic chemists because their unique ring systems and utility in drug discovery. Many natural containing spirocyclic moieties skeleton are effective pharmaceuticals. For many redox processes, electroorganic synthesis is considered an environmentally friendly method, since use reagents with significant toxicity replaced by electric current, so amount waste often greatly reduced. Therefore, this review summarizes construction a via electrochemical strategies 2000. 1 Introduction 2 Electrochemically Mediated Synthesis Spirocyclopropanes 3 Spirooxindoles 4 Spirodienones 5 Other Heterospirocycles 6 Conclusion
Language: Английский
Citations
10
The Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 88(19), P. 13977 - 13994
Published: Sept. 11, 2023
The combination of the Ugi reaction and electro-organic synthesis can aid in creation novel heterocycles that have not been previously explored. In this study, a new strategy utilizing bis-amides from has developed, which produce C–S, C–Se, C–C═O functionalized five-membered spirolactams mediated by electricity under catalyst- metal-free conditions. Notably, approach be applied using microelectro-flow reactor (μ-EFR) for gram-scale synthesis. described synthesize complex azaspiro-fused tricyclic scaffolds with high diastereo- regioselectivity, highlighting its versatility potential.
Language: Английский
Citations
10
The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(4), P. 2200 - 2211
Published: Feb. 8, 2024
Electrochemical dearomatization has been recognized as an attractive tool for the rapid construction of structurally diverse molecules. The designed methodology encompasses eco-friendly and efficient electrochemical approach to synthesizing spiro[4.5]dienones under mild reaction conditions. Furthermore, detailed mechanistic studies strongly bolster our hypothesis emphasize role HFIP in mechanism. protocol is scalable showcases a broad substrate scope with tolerance toward numerous functional groups. Henceforth, this strategy can be deployed alternative sustainable accessing spiro[4.5]dienones.
Language: Английский
Citations
3
Organic Letters, Journal Year: 2024, Volume and Issue: 26(11), P. 2243 - 2248
Published: March 8, 2024
The preparation of polycyclic aromatic hydrocarbons (PAHs) by the Scholl reaction is typically performed using superstoichiometric oxidants. Herein, we develop an electrochemical continuous-flow to access PAHs that features a reduction in use supporting electrolytes and easy scale-up without changing conditions setups. This allows synthesis distorted containing three [5]helicene units possess intriguing electronic optical properties.
Language: Английский
Citations
3
Advanced Synthesis & Catalysis, Journal Year: 2023, Volume and Issue: 365(8), P. 1211 - 1216
Published: March 23, 2023
Abstract An electrochemical oxidative approach to spirooxazolidinones from phenol derivatives via intramolecular dearomative amination reactions is developed. This reaction proceeds without metal catalysts and external chemical oxidants, shows broad substrate scope diverse functional group compatibility. The synthetic utility of this strategy further exhibited by the gram‐scale synthesis late‐stage functionalization. By slightly tunning conditions, alcohols (1°, 2° 3°) can be afforded derivatives, which a good for deprotection para ‐methoxyphenyl (PMP) recover alcohol function. magnified image
Language: Английский
Citations
5
Chinese Journal of Chemistry, Journal Year: 2023, Volume and Issue: 42(9), P. 980 - 984
Published: Dec. 26, 2023
Comprehensive Summary The development of efficient and sustainable methods to obtain spirocyclic compounds is significance as these structures are widely found in pharmaceuticals agrochemicals. Herein, we disclose an electrochemical dearomative spirocyclization N ‐acyl sulfonamides a continuous‐flow cell. reaction simple without external catalysts or supporting electrolytes could be applied decagram‐scale synthesis.
Language: Английский
Citations
5
Topics in heterocyclic chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Citations
1