Regenerative Engineering and Translational Medicine, Journal Year: 2024, Volume and Issue: 10(3), P. 416 - 437
Published: Feb. 27, 2024
Language: Английский
Gels, Journal Year: 2023, Volume and Issue: 9(7), P. 523 - 523
Published: June 27, 2023
Polymer-based hydrogels are hydrophilic polymer networks with crosslinks widely applied for drug delivery applications because of their ability to hold large amounts water and biological fluids control release based on unique physicochemical properties biocompatibility. Current trends in the development hydrogel systems involve drugs response specific triggers such as pH, temperature, or enzymes targeted reduce potential systemic toxicity. In addition, developing injectable formulations that easily used sustain during this extended time is a growing interest. Another emerging trend synthesis nano other functional substances improving loading efficacy. Following these trends, advanced possessing mechanically improved properties, controlled rates, biocompatibility focus field. More complex multi-drug combination therapies will be developed advancements. polymer-based gaining increasing attention personalized medicine tailored patient, example, combinations, target-specific delivery, improvement disease treatment effectiveness, healthcare cost reduction. Overall, application advancing rapidly, towards more efficient effective future.
Language: Английский
Citations
316
Polymers, Journal Year: 2024, Volume and Issue: 16(2), P. 206 - 206
Published: Jan. 10, 2024
Degradable polymers (both biomacromolecules and several synthetic polymers) for biomedical applications have been promising very much in the recent past due to their low cost, biocompatibility, flexibility, minimal side effects. Here, we present an overview with updated information on natural degradable where a brief account different polysaccharides, proteins, viz. polyesters/polyamino acids/polyanhydrides/polyphosphazenes/polyurethanes relevant has provided. The various approaches transformation of these by physical/chemical means cross-linking, as polyblends, nanocomposites/hybrid composites, interpenetrating complexes, interpolymer/polyion functionalization, polymer conjugates, block graft copolymers, are described. degradation mechanism, drug loading profiles, toxicological aspects polymeric nanoparticles formed also defined. Biomedical polymer-based biomaterials wound dressing/healing, biosensors, delivery systems, tissue engineering, regenerative medicine, etc., highlighted. In addition, use such nano systems solve current problems is briefly reviewed.
Language: Английский
Citations
102
Bioactive Materials, Journal Year: 2024, Volume and Issue: 34, P. 269 - 281
Published: Jan. 1, 2024
Wound management is an important issue that places enormous pressure on the physical and mental health of patients, especially in cases infection, where increased inflammatory response could lead to severe hypertrophic scars (HSs). In this study, a hydrogel dressing was developed by combining high strength toughness, swelling resistance, antibacterial antioxidant capabilities. The matrix composed double network polyvinyl alcohol (PVA) agarose with excellent mechanical properties. Hyperbranched polylysine (HBPL), highly effective cationic polymer, tannic acid (TA), strong molecule, were added as functional components. Examination properties confirmed full play efficacy HBPL TA. vivo studies methicillin-resistant Staphylococcus aureus (MRSA) had shown obvious promotion wound healing, more profoundly, significant suppression scar formation. Due common raw materials simple preparation methods, can be mass produced used for accelerating healing while preventing HSs infected wounds.
Language: Английский
Citations
86
Microorganisms, Journal Year: 2023, Volume and Issue: 11(6), P. 1541 - 1541
Published: June 9, 2023
Bacterial exopolysaccharides (EPS) are essential natural biopolymers used in different areas including biomedicine, food, cosmetic, petroleum, and pharmaceuticals also environmental remediation. The interest them is primarily due to their unique structure properties such as biocompatibility, biodegradability, higher purity, hydrophilic nature, anti-inflammatory, antioxidant, anti-cancer, antibacterial, immune-modulating prebiotic activities. present review summarizes the current research progress on bacterial EPSs properties, biological functions, promising applications various fields of science, industry, medicine, technology, well characteristics isolation sources EPSs-producing strains. This provides an overview latest advances study important industrial xanthan, cellulose, levan. Finally, limitations future directions discussed.
Language: Английский
Citations
68
Gels, Journal Year: 2023, Volume and Issue: 9(7), P. 539 - 539
Published: July 3, 2023
Aloe vera-based hydrogels have emerged as promising platforms for the delivery of therapeutic agents in wound dressings due to their biocompatibility and unique wound-healing properties. The present study provides a comprehensive overview recent advances application healing. synthesis methods, structural characteristics, properties are discussed. Mechanisms released from hydrogels, including diffusion, swelling, degradation, also analyzed. In addition, effects on healing, well reduction inflammation, antimicrobial activity, tissue regeneration, highlighted. incorporation various agents, such anti-inflammatory ones, into is reviewed detail. Furthermore, challenges future prospects dressing applications considered. This review valuable information current status highlights potential improve healing outcomes.
Language: Английский
Citations
65
Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 324, P. 121537 - 121537
Published: Nov. 2, 2023
Language: Английский
Citations
57
International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 247, P. 125754 - 125754
Published: July 8, 2023
Language: Английский
Citations
56
ACS Nano, Journal Year: 2024, Volume and Issue: 18(26), P. 17251 - 17266
Published: June 22, 2024
Designing adaptive and smart hydrogel wound dressings to meet specific needs across different stages of healing is crucial. Here, we present a composite hydrogel, GSC/PBE@Lut, that offers self-regulating release cupric ions luteolin modulates mechanical properties promote chronic healing. The double network GSC, fabricated through photo-cross-linking gelatin methacrylate, followed by Cu2+-alginate coordination cross-linking. On one hand, GSC allows for rapid Cu2+ eliminate bacteria in the acidic pH environment during inflammation reduces hydrogel's strength minimize tissue trauma early dressing changes. other enables slow proliferation stage, promoting angiogenesis biocompatibility. Furthermore, inclusion pH- reactive oxygen species (ROS)-responsive nanoparticles (PBE@Lut) matrix controlled luteolin, offering antioxidant anti-inflammatory effects macrophage polarization. In murine model Staphylococcus aureus infected wounds, GSC/PBE@Lut demonstrates exceptional therapeutic benefits antibacterial, anti-inflammatory, angiogenic, regeneration. Overall, our results suggest hydrogels with bioactive agent modulation promising solution treating wounds.
Language: Английский
Citations
50
Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 207, P. 115217 - 115217
Published: Feb. 27, 2024
Language: Английский
Citations
24
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 510, P. 215799 - 215799
Published: April 1, 2024
Language: Английский
Citations
22