Nature Communications,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: Sept. 28, 2023
One-pot
synthesis
of
heterocyclic
aromatics
with
good
optical
properties
from
phenolic
β-O-4
lignin
segments
is
high
importance
to
meet
value
added
biorefinery
demands.
However,
executing
this
process
remains
a
huge
challenge
due
the
incompatible
reaction
conditions
depolymerization
containing
γ-OH
functionalities
and
bioresource-based
aggregation-induced
emission
luminogens
(BioAIEgens)
formation
desired
properties.
In
work,
benzannulation
reactions
starting
moieties
3-alkenylated
indoles
catalyzed
by
vanadium-based
complexes
have
been
successfully
developed,
affording
wide
range
functionalized
carbazoles
up
92%
yield.
Experiments
density
functional
theory
calculations
suggest
that
pathway
involves
selective
cleavage
double
C-O
bonds/Diels-Alder
cycloaddition/dehydrogenative
aromatization.
Photophysical
investigations
show
these
carbazole
products
represent
class
BioAIEgens
twisted
intramolecular
charge
transfer.
Distinctions
behavior
were
revealed
based
on
unique
acceptor-donor-acceptor-type
molecular
conformations
as
well
packings.
This
work
features
motifs
renewable
substrates,
without
need
apply
external
oxidant/reductant
systems.
Here,
we
concise
sustainable
route
AIE
properties,
building
bridge
between
BioAIE
materials.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(52)
Published: Nov. 17, 2023
Stubborn
biofilm
infections
pose
serious
threats
to
human
health
due
the
persistence,
recurrence,
and
dramatically
magnified
antibiotic
resistance.
Photodynamic
therapy
has
emerged
as
a
promising
approach
combat
biofilm.
Nevertheless,
how
inhibit
bacterial
signal
transduction
system
efflux
pump
conquer
recurrence
resistance
remains
challenging
unaddressed
issue.
Herein,
boric
acid-functionalized
lipophilic
cationic
type
I
photosensitizer,
ACR-DMP,
is
developed,
which
efficiently
generates
•OH
overcome
hypoxic
microenvironment
photodynamically
eradicates
methicillin-resistant
Staphylococcus
aureus
(MRSA)
biofilms.
Furthermore,
it
not
only
alters
membrane
potential
homeostasis
osmotic
pressure
balance
its
strong
binding
ability
with
plasma
but
also
inhibits
quorum
sensing
two-component
system,
reduces
virulence
factors,
regulates
activity
of
drug
attributed
glycan-targeting
ability,
helping
prevent
In
vivo,
ACR-DMP
successfully
obliterates
MRSA
biofilms
attached
implanted
medical
catheters,
alleviates
inflammation,
promotes
vascularization,
thereby
combating
accelerating
wound
healing.
This
work
provides
an
efficient
strategy
stubborn
multidrug
offers
systematic
guidance
for
rational
design
next-generation
advanced
antimicrobial
materials.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(13)
Published: Jan. 26, 2023
Abstract
Uniting
photothermal
therapy
(PTT)
with
magnetic
resonance
imaging
(MRI)
holds
great
potential
in
nanotheranostics.
However,
the
extensively
utilized
hydrophobicity‐driven
assembling
strategy
not
only
restricts
intramolecular
motion‐induced
PTT,
but
also
blocks
interactions
between
MR
agents
and
water.
Herein,
we
report
an
aggregation‐induced
emission
luminogen
(AIEgen)‐mediated
polyelectrolyte
nanoassemblies
(APN)
strategy,
which
bestows
a
unique
“soft”
inner
microenvironment
good
water
permeability.
Femtosecond
transient
spectra
verify
that
APN
well
activates
motion
from
twisted
charge
transfer
process.
This
de
novo
uniting
synergistically
three
factors
(rotational
motion,
local
hydration
number)
brings
out
high
relaxivity.
For
first
time,
has
successfully
modulated
both
relaxivity,
achieving
fluorescence
lifetime
of
tumor
spheroids
spatio‐temporal
MRI‐guided
high‐efficient
PTT.
Chemical Science,
Journal Year:
2023,
Volume and Issue:
14(25), P. 7076 - 7085
Published: Jan. 1, 2023
Precisely
engineering
the
electron
donor
in
a
twisted
D–π–A
system
achieves
mitochondria-targeting
and
AIE-active
NIR
photosensitizers
with
1
O
2
quantum
yield
up
to
6.8
times
that
of
Rose
Bengal.
image-guided
PDT
has
thus
been
realized.
Nature Communications,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: Sept. 28, 2023
One-pot
synthesis
of
heterocyclic
aromatics
with
good
optical
properties
from
phenolic
β-O-4
lignin
segments
is
high
importance
to
meet
value
added
biorefinery
demands.
However,
executing
this
process
remains
a
huge
challenge
due
the
incompatible
reaction
conditions
depolymerization
containing
γ-OH
functionalities
and
bioresource-based
aggregation-induced
emission
luminogens
(BioAIEgens)
formation
desired
properties.
In
work,
benzannulation
reactions
starting
moieties
3-alkenylated
indoles
catalyzed
by
vanadium-based
complexes
have
been
successfully
developed,
affording
wide
range
functionalized
carbazoles
up
92%
yield.
Experiments
density
functional
theory
calculations
suggest
that
pathway
involves
selective
cleavage
double
C-O
bonds/Diels-Alder
cycloaddition/dehydrogenative
aromatization.
Photophysical
investigations
show
these
carbazole
products
represent
class
BioAIEgens
twisted
intramolecular
charge
transfer.
Distinctions
behavior
were
revealed
based
on
unique
acceptor-donor-acceptor-type
molecular
conformations
as
well
packings.
This
work
features
motifs
renewable
substrates,
without
need
apply
external
oxidant/reductant
systems.
Here,
we
concise
sustainable
route
AIE
properties,
building
bridge
between
BioAIE
materials.
