Rearranging fluorescence‐magneto spatiality for “win‐win” dual functions to enhance point‐of‐care diagnosis

Aggregate, Journal Year: 2023, Volume and Issue: 5(2)

Published: Nov. 10, 2023

Abstract Fluorescent‐magneto nanoemitters have gained considerable attention for their applications in mechanical controlling‐assisted optical signaling. However, the incompatibility between magnetic and fluorescent components often leads to functional limitations traditional magneto@fluorescence nanostructure. Herein, we introduce a new compact‐discrete spatial arrangement on “fluorescence@magneto” core–shell nanostructure consisting of close‐packed aggregation‐induced emission luminogen (AIEgen) core discrete shell. This structural design effectively eliminates interferences dual by facilitating AIEgens loading region reducing feeding amount through effective exposure units. Thereby, resulting magneto‐AIEgen nanoparticle (MANP) demonstrates “win‐win” performances: (i) high intensity contributed stacking‐enhanced photoluminescence reduced photons loss from meager shell; (ii) marked activity due magneto extraposition‐minimized shielding. Accordingly, functions‐retained MANP provides proof concept construction an immunochromatographic sensing platform, where it enables bright labeling after magnetically enriching separating procalcitonin lipoarabinomannan clinical human serum urine, respectively, diagnosis bacterial infections‐caused inflammation tuberculosis. study not only inspires rational magnetic‐fluorescent nanoemitter but also highlights promising potential magneto‐assisted point‐of‐care test biomedicine applications.

Language: Английский

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Boron- and Nitrogen-Embedded Polycyclic Arenes as an Emerging Class of Organic Semiconductors

Chemistry of Materials, Journal Year: 2023, Volume and Issue: 35(24), P. 10277 - 10294

Published: Dec. 11, 2023

The development of novel organic semiconductors has continuously promoted the field optoelectronics. During past decade, boron- and nitrogen-embedded (BN-embedded) polycyclic arenes have attracted considerable attention, enriching structural diversity providing a broad space for tuning their optoelectronic properties. application BN-embedded conjugated materials in different devices achieved excellent performance, e.g., high charge-carrier mobilities (μ > 1.0 cm2 V–1 s–1) field-effect transistors (OFETs), ultrapure electroluminescence (full-width at half-maximum ≤ 18 nm) light-emitting diodes (OLEDs), power conversion efficiency (PCE 19%) photovoltaics (OPVs). These advances make promising class high-performance semiconductors. Nevertheless, inherent relationship between BN-doping modes properties never been systematically discussed. In this Perspective, we aim to present an overview unique family by selecting representative examples. We will first outline characters modes, discuss effect on electronic structures arenes, finally showcase advanced applications emerging devices. hope bring together communities further promote semiconductor materials.

Language: Английский

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Redox-activated photosensitizers for visualizing precise diagnosis and potentiating cancer therapy

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 507, P. 215734 - 215734

Published: March 5, 2024

Language: Английский

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Tuning Molecular Packing by Twisting Structure to Facilely Construct Highly Efficient Solid‐State Fluorophores for Two‐Photon Bioimaging and Photodynamic Therapy

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(27)

Published: March 7, 2024

Abstract The traditional design strategy for constructing highly bright solid‐state luminescent materials relies on incorporating aggregation‐induced emission (AIE) scaffolds, molecular rotors, or bulky substituents to prevent close cofacial packing, which limits the diversity in developing new materials. Herein, a of tuning packing by twisting structure conventional aggregation‐caused quenching fluorophore is proposed endow with AIE effect and enhance fluorescence. Accordingly, series 1,4‐bis(diphenylamino)‐2,5‐disubstituted benzene fluorophores exhibiting characteristics, high fluorescence efficiency (up 0.99), wide color tunability, good near‐infrared (NIR) two‐photon absorption facilely developed. All these luminogens can specifically stain intracellular lipid droplets signal‐to‐noise ratio, biocompatibility, photostability. Besides, exhibit effective reactive oxygen species (ROS) generation capability upon low‐power white light irradiation. Among them, luminogen, named BDBDC, integrating NIR emission, strongest ROS demonstrates superior performances imaging various tissues photodynamic cancer therapy. This philosophy provides way designing practical applications.

Language: Английский

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Magnetic nanomaterials as green and recoverable nanocatalysts: Research on synthesis of benzimidazole derivatives

Synthetic Communications, Journal Year: 2024, Volume and Issue: 54(9), P. 709 - 734

Published: March 28, 2024

Research on benzimidazole derivatives is always an attractive challenge among synthetic chemists because are very key and important components in the structure of many drugs, biological active molecules, natural products. Benzimidazole interesting their valuable medicinal activities, such as anti-bacterial, anti-cancer, anti-tuberculosis, anti-fungal, pain killer, anti-HIV activities. During last decade, most reports field catalysts have been related to magnetic nanocatalysts, which shows high popularity remarkable efficiency this type catalyst performing chemical reactions. Magnetic nanocatalysts ideal both from point view green chemistry economically they easily separated reaction mixture significant catalytic activity. In review article, we summarized methods presented synthesis various based use nanomaterials recoverable catalysts.

Language: Английский

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A novel fluorescent chemosensor enables dual-channel selective “turn-on” detection of Hg²⁺ and Ag⁺via distinct thiophilic effects, essential mechanisms, and excellent sensing performance for mercury(ii) in aggregated states

Journal of Materials Chemistry C, Journal Year: 2024, Volume and Issue: 12(21), P. 7572 - 7579

Published: Jan. 1, 2024

A fluorescent probe enables dual-channel selective “turn-on” detection of Hg 2+ and Ag + via distinct thiophilic effects was designed. Mechanisms this chemosensor the opposite luminescence behavior molecules were carefully explored.

Language: Английский

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A biosensor based on nanocomposite of g-C3N4 and polyaniline for detection of fentanyl as a doping agent in sports

Alexandria Engineering Journal, Journal Year: 2024, Volume and Issue: 87, P. 515 - 523

Published: Jan. 1, 2024

Significant ethical and health concerns have been brought up recently by the illegitimate use of highly strong synthetic opioids, including fentanyl, as doping agents in sports. Therefore, requirement for quick accurate detection techniques to spot illicit drugs athletes has never more important. Our study presents a novel biosensor sensitive fentanyl based on nanocomposite polyaniline (PANI) glassy carbon electrode modified with g-C3N4, which is first its kind. The g-C3N4-PANI nanocomposite's successful synthesis was confirmed structural investigations performed using SEM, XRD, FT-IR. Studies electrochemical effects g-C3N4 PANI cyclic voltammetry (CV) amperometry revealed that hybrid composite enhanced sensitivity, selectivity, stability, accuracy measurement. With sensitivity 0.45445 μA/μM, measurements broad consistent linear range spanning from 10 920 μM. threshold established at 0.006 Additionally, performance assessed several real-samples made athlete pee. findings displayed satisfactory recovery values ranging 90.00% 98.00% low relative standard deviation (less than 4.74%) demonstrated g-C3N4/PANI nanocomposite-based potential be an effective anti-doping control tool, opening door practical maintaining fairness safety competitive analysis showed combination resulted material properties, contributed high biosensor.

Language: Английский

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CeO2/MnFe2O4 nanocomposite: Structural, magnetic, electrochemical and cytotoxicity properties

Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: unknown, P. 113624 - 113624

Published: Nov. 1, 2024

Language: Английский

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Synthesis, antimicrobial, and in silico studies of c5′- O -substituted cytidine derivatives: cinnamoylation leads to improvement of antimicrobial activity

Nucleosides Nucleotides & Nucleic Acids, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 39

Published: March 28, 2024

Nucleoside derivatives are important therapeutic drugs that have drawn significant attention recently. In this study, cytidine (1) was first exposed to react with cinnamoyl chloride in N,N-dimethylformamide, and trimethylamine obtain 5′-O-(cinnamoyl)cytidine, which further treated several acylating agents a series of 2′,3′-di-O-acyl derivatives. The chemical structures the synthesized compounds were established through spectral, analytical, physicochemical techniques. vitro antimicrobial efficacy evaluated, effect greater than precursor compound; particular, compound 3 exhibited most promising activity. Cytotoxicity measurements revealed demonstrated decreased degree toxicity. A structure-activity relationship (SAR) study showed ribose moiety combined acyl chains (C-12/C13) (C6H5CH = CHCO) had enhanced effects on bacteria fungi. Molecular docking applied for potential inhibitors (3, 4, 6) predict their mode action confirm against isozymes, tubulin-like protein TubZ, Bacillus cereus [PDB: 4ei9], dihydrofolate reductase Aspergillus flavus 6dtc]. molecular dynamics simulation performed evaluate deformability, flexibility, stiffness target enzyme residues. Density functional theory (DFT) indicates high polarizability reactivity compounds. ADMET (absorption, distribution, mechanism, excretion, toxicity) suggested all designed molecules moderate human intestinal absorption good distribution values addition absence CNS side structural Above else, these possess behavior, thereby rendering them suitable drug candidate(s) additional exploration.

Language: Английский

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Insight into the Stokes shift, divergent solvatochromism and aggregation-induced emission of boron complexes with locked and unlocked benzophenanthridine ligands

Dyes and Pigments, Journal Year: 2022, Volume and Issue: 209, P. 110924 - 110924

Published: Nov. 10, 2022

Two four-coordinate boron complexes, compounds 5 and 7, have been synthesized, using analogous benzophenanthridine-based ligands but showing different conformational constraints, their optical properties investigated. Following a ligand design that takes into consideration the expansion of π-conjugation structural desymmetrization has proved to be useful approach obtain fluorophores with large Stokes shifts. The analysis Huang-Rhys parameters along vibrational modes revealed incorporation conformationally free substructure entails an enhanced shift as result increased geometry relaxation in first excited state (S1) ground (S0). Additionally, sensitivity solvent polarity showed divergent solvatochromism (bathochromism emission spectra hypsochromism absorption spectra) whose origin ascribed by experimental theoretical methods dissimilar extent stabilization S0 S1 states respect corresponding Franck-Condon states. Besides, formation aggregates dimethylformamide/water mixtures related solid packing, determined X-ray diffraction, explain aggregation-induced effects on emissive reported organoboron complexes. less restricted molecule, displayed (AIE) promoted upon blocking motion peripheral rotor.

Language: Английский

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