Published: Jan. 1, 2023
Language: Английский
Chemical Science, Journal Year: 2022, Volume and Issue: 14(3), P. 409 - 442
Published: Dec. 2, 2022
This review presents discrete metal complexes that catalyse or photocatalyse reactions within living cells organisms.
Language: Английский
Citations
52
Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(5), P. 2895 - 2900
Published: Jan. 26, 2024
Performing abiotic synthetic transformations in live cell environments represents a new, promising approach to interrogate and manipulate biology uncover new types of biomedical tools. We now found that photocatalytic bond-forming reactions can be added the toolbox bioorthogonal chemistry. Specifically, we demonstrate exogenous styryl aryl azides converted into indoles inside living mammalian cells under conditions.
Language: Английский
Citations
15
Trends in Chemistry, Journal Year: 2023, Volume and Issue: 5(6), P. 474 - 485
Published: April 29, 2023
Language: Английский
Citations
21
Accounts of Chemical Research, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 20, 2024
ConspectusThe evolutionary complexity of compartmentalized biostructures (such as cells and organelles) endows life-sustaining multistep chemical cascades intricate living functionalities. Relatively, within a very short time span, synthetic paradigm has resulted in tremendous growth controlling the materials at different length scales (molecular, nano, micro, macro), improving mechanistic understanding setting design principals toward compositions, configurations, structures, turn fine-tuning their optoelectronic catalytic properties for targeted applications. Bioorthogonal catalysis offers highly versatile toolkit biochemical modulation capability to perform new-to-nature reactions inside systems, endowing augmented functions. However, conventional catalysts have limitations control under physiological conditions due hostile bioenvironment. The present account details development bioapplicable multicomponent designer nanoreactors (NRs), where morphologies, interfacial active sites, microenvironments around metal nanocatalysts can be precisely controlled by novel nanospace-confined chemistries. Different architectures porous, hollow, open-mouth silica-based nano-housings facilitate accommodation, protection, selective access nanoscale metal-based sites. modular porosity/composition, optical transparency, thermal insulation, nontoxicity silica are useful. Moreover, large macropores or cavities also occupied enzymes (for chemoenzymatic cascades) selectivity enhancers stimuli-responsive gating) along with nanocatalysts. Further, it is crucial selectively activate remotely operable biocompatible energy source. Integration coupled plasmonic (Au) components having few-nanometer structural features (gaps, cavities, junctions electromagnetic hot-spots) an opportunity efficiently harness low-power NIR light supply sites through localized photothermal electronic effects. plasmonically integrated NRs customizable plasmonic-catalytic components, bilayer nanospaces, metal-laminated nanocrystals hollow NIR-/light-induced complex media including cells. In addition, magnetothermia-induced metals on pre-installed superparamagnetic iron-oxide core hollow-porous shell endowed apply AMF bioorthogonal stimulus promote reactions. By combining "plasmonic-catalytic" "magnetic-catalytic" single NR, two distinct reaction steps desirably sources (NIR AMF) regimes. organic molecular transformations harmony natural system will reveal schemes cellulo synthesis drug bioimaging probes. Well-designed discrete spatiotemporal over abiotic without adversely affecting cell viability. in-depth heterogeneous surface reactions, rate induction mechanisms, pathways, nanobio interactions necessary. broad field biomedical engineering hugely benefit from aid nanomaterials chemistry-based designs engineered performing unique chemistry
Language: Английский
Citations
8
Helvetica Chimica Acta, Journal Year: 2023, Volume and Issue: 106(4)
Published: Jan. 31, 2023
Abstract Recent years have witnessed a considerable progress in research aimed at merging transition metal catalysis with chemical and cell biology. Therefore, crescent number of metal‐catalyzed transformations been shown compatible biological media even living settings. Of the different metals used to build these biocompatible catalysts, ruthenium has demonstrated be particularly powerful, part because resulting complexes exhibit very good balance between reactivity stability. Indeed, utility promote great variety reactions biologically relevant contexts, from deprotection redox processes cycloadditions or photocatalytic transformations. Many may enable development new type tools pharmacological strategies.
Language: Английский
Citations
14
Chemical Communications, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
We report a systematic tuning of chelation ring strain on the hemilability platinum-based coordination complexes made from weak link approach.
Language: Английский
Citations
0
Tetrahedron Letters, Journal Year: 2025, Volume and Issue: unknown, P. 155547 - 155547
Published: March 1, 2025
Language: Английский
Citations
0
Organic & Biomolecular Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
We report two potentially biocompatible photoredox systems for the activation and coupling of redox-active esters using low-energy light BnNAH as reductant.
Language: Английский
Citations
0
ACS Catalysis, Journal Year: 2025, Volume and Issue: 15(10), P. 8624 - 8632
Published: May 8, 2025
The discovery and development of artificial catalysts to carry out bioorthogonal reactions in living cells is a primary goal at the interface Chemistry Biology. Current approaches rely on time-consuming trial-and-error methods. As an alternative, we show that positionally addressable combinatorial libraries (SPOT libraries) provide significant advantage for efficient identification novel catalytic metallopeptides. Using these libraries, were able rapidly identify β-hairpin palladopeptides capable promoting depropargylation challenging intracellular environments.
Language: Английский
Citations
0
Published: Jan. 1, 2025
Abstract Bioorthogonal chemistry has revolutionized the field of chemical biology, providing powerful tools for manipulating molecules in biological environments, including living cells and organisms. For many years, these transformations have been mainly limited to well-known copper-catalyzed azide–alkyne cycloadditions (CuAAC) metal-free reactions with strained reagents. However, recent years it widely demonstrated that some transition-metal-catalyzed may also be performed settings, enabling, among other applications, bioimaging targets structures or pro drug activations. Particularly attractive is possibility using organometallic catalysis performing synthetic, bond-forming reactions, as this can lead new types technologies exploration biomedical discovery.
Language: Английский
Citations
0