Chemical Communications,
Journal Year:
2023,
Volume and Issue:
59(53), P. 8266 - 8269
Published: Jan. 1, 2023
Water-soluble
[3]pseudorotaxane
based
on
pillar[5]arene
with
enhanced
fluorescence
emission
has
been
constructed
successfully,
and
can
be
further
applied
in
cell
imaging
both
type
I
&
II
photodynamic
cancer
therapy.
Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(7), P. 4081 - 4087
Published: Feb. 13, 2023
The
highly
oxygen-dependent
nature
of
photodynamic
therapy
(PDT)
limits
its
therapeutic
efficacy
against
hypoxic
solid
tumors
in
clinics,
which
is
an
urgent
problem
to
be
solved.
Herein,
we
develop
oxygen-independent
supramolecular
agent
that
produces
hydroxyl
radical
(•OH)
by
oxidizing
water
the
presence
intracellularly
abundant
pyruvic
acid
under
oxygen-free
conditions.
A
fluorene-substituted
BODIPY
was
designed
as
electron
donor
and
coassembled
with
perylene
diimide
acceptor
form
quadruple
hydrogen-bonded
agent.
Detailed
mechanism
studies
reveal
intermolecular
transfer
charge
separation
upon
light
irradiation
result
efficient
generation
ion
pairs.
Under
conditions,
cationic
radicals
directly
oxidize
generate
cytotoxic
•OH,
anionic
electrons
acid,
realizing
catalytic
cycle.
Thus,
this
exhibited
superb
photocytotoxicity
even
severe
environments
excellent
vivo
antitumor
on
HeLa-bearing
mouse
models.
This
work
provides
a
strategy
for
constructing
agents,
opens
up
avenue
effective
PDT
tumors.
Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: July 20, 2022
Abstract
The
development
of
advanced
materials
for
information
encryption
with
time-dependent
features
is
essential
to
meet
the
increasing
demand
on
security.
Herein,
smart
orthogonal
and
temporal
properties
are
successfully
developed
based
a
dynamic
assembly-induced
multicolour
supramolecular
system.
Multicolour
fluorescence,
including
blue,
orange
even
white
light
emissions,
achieved
by
controlling
assembly
pyrene
derivatives
tailoring
solvent
composition.
By
taking
advantage
tuneable
dynamically
controlled
functions,
e.g.,
3D
codes,
developed.
Moreover,
materials,
such
as
multi-information
displays
4D
also
enabling
fluorescence-controllable
system
in
solid
phase,
showing
multiple
pieces
time
scale,
correct
can
be
identified
only
at
specified
time.
This
work
provides
an
inspiring
point
design
higher
security
requirements.
Advanced Materials,
Journal Year:
2022,
Volume and Issue:
35(18)
Published: Nov. 18, 2022
Abstract
The
use
of
boron
dipyrromethene
(BODIPY)
in
biomedicine
is
reviewed.
To
open,
its
synthesis
and
regulatory
strategies
are
summarized,
inspiring
cutting‐edge
work
post‐functionalization
highlighted.
A
brief
overview
assembly
model
BODIPY
then
provided:
introduced
as
a
promising
building
block
for
the
formation
single‐
multicomponent
self‐assembled
systems,
including
nanostructures
suitable
aqueous
environments,
thereby
showing
great
development
potential
supramolecular
applications.
frontier
progress
biomedical
application
thereafter
described,
supported
by
examples
frontiers
applications
BODIPY‐containing
smart
materials:
it
mainly
involves
materials
based
on
blocks
their
assemblies
fluorescence
bioimaging,
photoacoustic
imaging,
disease
treatment
photodynamic
therapy,
photothermal
immunotherapy.
Lastly,
not
only
current
status
family
field
but
also
challenges
worth
considering
summarized.
At
same
time,
insights
into
future
prospects
biomedically
applicable
provided.
Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(14), P. 8130 - 8140
Published: March 31, 2023
Type
I
photosensitization
provides
an
effective
solution
to
the
problem
of
unsatisfactory
photodynamic
therapeutic
(PDT)
effects
caused
by
tumor
hypoxia.
The
challenge
in
development
mode
is
boost
photosensitizer's
own
electron
transfer
capacity.
Herein,
we
found
that
use
bovine
serum
albumin
(BSA)
encapsulate
a
thermally
activated
delayed
fluorescence
(TADF)
photosensitizer
PS
can
significantly
promote
PDT
process
generate
mass
superoxide
anions
(O2•–).
This
opened
new
strategy
employing
BSA
as
"electron
reservoir"
and
TADF
pump".
We
integrated
these
roles
one
system
preparing
nanophotosensitizer
PS@BSA.
performance
was
demonstrated
with
cells
under
hypoxic
conditions.
Furthermore,
PS@BSA
took
full
advantage
tumor-targeting
role
achieved
efficient
for
tumor-bearing
mice
vivo
experiments.
work
route
improve
efficiency
tumors.
Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: Oct. 19, 2022
Abstract
Given
that
Type-I
photosensitizers
(PSs)
have
hypoxia
tolerance,
developing
general
approaches
to
prepare
PSs
is
of
great
importance,
but
remains
a
challenge.
Here,
we
report
supramolecular
strategy
for
the
preparation
photodynamic
agents,
which
simultaneously
generate
strong
oxidizing
cationic
radicals
and
superoxide
radicals,
by
introducing
electron
acceptors
existing
Type-II
PSs.
As
proof-of-concept,
three
were
designed
co-assembled
with
classical
PS
produce
quadruple
hydrogen-bonded
agents.
The
photo-induced
transfer
from
adjacent
acceptor
occurs
efficiently,
leading
generation
+•
an
anionic
radical
acceptor,
further
transfers
oxygen
form
O
2
−•
.
In
addition,
these
agents
induce
direct
photocatalytic
oxidation
NADH
turnover
frequency
as
high
53.7
min
−1
,
offers
oxygen-independent
mechanism
damage
tumors.
Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(43), P. 23397 - 23415
Published: Oct. 17, 2023
Ruthenium(II)
polypyridyl
complexes
form
a
vast
family
of
molecules
characterized
by
their
finely
tuned
photochemical
and
photophysical
properties.
Their
ability
to
undergo
excited-state
deactivation
via
photosubstitution
reactions
makes
them
quite
unique
in
inorganic
photochemistry.
As
consequence,
they
have
been
used,
general,
for
building
dynamic
molecular
systems
responsive
light
but,
more
particularly,
the
field
oncology,
as
prodrugs
new
cancer
treatment
modality
called
photoactivated
chemotherapy
(PACT).
Indeed,
coordination
bond
be
selectively
broken
under
visible
irradiation
offers
fascinating
perspectives
oncology:
it
is
possible
make
poorly
toxic
agents
dark
that
become
activated
toward
cell
killing
simple
compound
inside
tumor.
In
this
Perspective,
we
review
most
important
concepts
behind
PACT
idea,
relationship
between
ruthenium
compounds
used
those
related
phototherapeutic
approach
photodynamic
therapy
(PDT),
discuss
questions
about
real-life
applications
clinic.
We
conclude
Perspective
with
challenges
an
outlook.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(19)
Published: March 2, 2023
It
is
a
challenge
to
design
photosensitizers
balance
between
the
tumor-targeting
enrichment
for
precise
treatment
and
efficient
clearance
within
reasonable
timescale
reducing
side
effects.
Herein,
an
ultra-small
nano-photosensitizer
1a
with
excellent
tumor-specific
accumulation
renal
reported.
formed
from
self-assembly
of
compound
1
bearing
three
triethylene
glycol
(TEG)
arms
two
pyridinium
groups
in
water.
The
positively
charged
surface
neutral
TEG
coating
enables
efficiently
target
tumor,
signal-to-background
ratio
reaching
as
high
11.5
after
tail
intravenous
injection.
size
average
diameter
5.6
nm
allows
its
fast
through
kidney.
Self-assembly
also
endows
18.2-fold
enhancement
reactive
oxygygen
species
generation
rate
compared
organic
solution.
Nano-PS
manifests
photodynamic
therapy
efficacy
on
tumor-bearing
mouse
models.
This
work
provides
promising
strategy
clearable
ability.