Papain-capped gold nanoflowers: dual functionality as peroxidase mimic and 4-nitrophenol reduction catalysts DOI Creative Commons
Dan Yan, Juan Liu, Yuanyuan Chen

et al.

Published: Oct. 8, 2024

A bifunctional ensemble of papain-capped gold nanoparticles (AuNFs) exhibits dual functionality, manifesting peroxidaselike and 4-nitrophenol reduction activities. The AuNFs, possessing an average size approximately 82.27 ± 1.95 nm, are synthesized under ambient conditions through the mediation papain, wherein HAuCl4 by ascorbic acid is facilitated. These nanoflowers capable catalyzing H2O2 to oxidize target 3,3,5,5-tetramethylbenzidine, resulting in production a visual color blue. Therefore, simple method providing sensitivity 0.44 µM (signal/noise ratio = 2) linearity within range 0 40 available detect colorimetry. Subsequently, chemical activity associated with 4-NP (4-nitrophenol) was studied, it found exhibit catalysis rate 0.29 min-1 , surpassing that alternative catalysts. findings underscore potential utility our AuNFs catalytic biosensing applications.

Language: Английский

Exploration of inorganic nanoparticles for revolutionary drug delivery applications: a critical review DOI Creative Commons
Gayathri Unnikrishnan, Anjumol Joy,

M. Megha

et al.

Discover Nano, Journal Year: 2023, Volume and Issue: 18(1)

Published: Dec. 19, 2023

The nanosystems for delivering drugs which have evolved with time, are being designed greater drug efficiency and lesser side-effects, also complemented by the advancement of numerous innovative materials. In comparison to organic nanoparticles, inorganic nanoparticles stable, a wide range physicochemical, mechanical, magnetic, optical characteristics, capability get modified using some ligands enrich their attraction towards molecules at target site, makes them appealing bio-imaging delivery applications. One strong benefits nanoparticles-drug conjugate is possibility affected cells locally, thus reducing side-effects like cytotoxicity, facilitating higher efficacy therapeutic drug. This review features direct indirect effects such gold, silver, graphene-based, hydroxyapatite, iron oxide, ZnO, CeO2 in developing effective carrier systems. article has remarked peculiarities these nanoparticle-based systems pulmonary, ocular, wound healing, antibacterial deliveries as well across Blood-Brain-Barrier (BBB) acting agents cancer theranostics. Additionally, sheds light on plausible modifications that can be carried out from researcher's perspective, could open new pathway.

Language: Английский

Citations

54
Development of a versatile biomaterial of chitosan polymer/ginger (Zingiber officinale Roscoe) extract/ZnO bionanocomposite: physicochemical properties, antioxidant activity, and breast cancer therapy DOI

Muthanna O. Hussein,

Ahmed Saud Abdulhameed

Research on Chemical Intermediates, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 11, 2025

Language: Английский

Citations

2
Recent advances in gold Janus nanomaterials: Preparation and application DOI
Yunbo Li,

Minqiang Xia,

Jiahang Zhou

et al.

Advances in Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 334, P. 103315 - 103315

Published: Oct. 18, 2024

Language: Английский

Citations

9
DNA and Nanomaterials: A Functional Combination for DNA Sensing DOI
Mohzibudin Z. Quazi,

Jang Hyeon Choi,

Min‐Chul Kim

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(2), P. 778 - 786

Published: Jan. 25, 2024

Recent decades have experienced tough situations due to the lack of reliable diagnostic facilities. The most recent cases occurred during pandemic, where researchers observed facilities with precision. Microorganisms and viral disease's ability escape diagnosis has been a global challenge. DNA always unique moiety strong precise base-paired structure. in human foreign particles makes identification possible through base pairing. Since then, focused heavily on designing assays targeting particular. Moreover, nanotechnology contributed vastly composite nanomaterials by combining DNA/nucleic acids functional inorganic nanoparticles exploiting their physicochemical properties. These often exhibit or enhanced properties synergistic activity many components. capabilities additional shown combination robust advanced tailoring biosensors. Preceding findings state that conventional strategies exhibited certain limitations such as low range target detection, less biodegradability, subordinate half-life, high susceptibility microenvironments; however, DNA–nanomaterial-based biosensor overcome these meaningfully. Additionally, nucleic studied extensively signal conduction abilities. Here, we review studies biosensors, mechanism action, improved/updated vivo situ. Furthermore, this highlights methodologies utilization exploit interfacial sensing. Lastly, concludes limitations/challenges future directions.

Language: Английский

Citations

8
Silica-Coated Gold Nanorods (AuNR@SiO2): Synthesis, Properties and Applications in Biomedicine and Beyond DOI
Satyabrata Si,

Amrita Ghosh Majumdar,

Priti S. Mohanty

et al.

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 16, 2025

Language: Английский

Citations

0
Gold Nanocluster-Based Self-Assembly Fluorescence Microbeads for Sensor Array Discrimination of Multicomponent Metal Ions DOI
Xing Dong, Yixing Tian,

Fengxiang Ai

et al.

Inorganic Chemistry, Journal Year: 2024, Volume and Issue: 63(35), P. 16264 - 16273

Published: Aug. 19, 2024

Benefiting from easy visualization and simultaneous detection of multiple targets, fluorescence microbeads are commonly used as fluorescence-sensing elements to detect pollutants in the environment. However, application microbead-based sensor arrays is still limited because dyes always suffer self-quenching, photobleaching, spectral overlap. Herein, three kinds gold nanoclusters (Au NCs) were assembled with polystyrene microspheres (PS NPs) by electrostatic interaction prepare (PS-Au NCs), developing a array for analysis metal ions. In this work, different PS-Au NCs showed an enhancing or quenching response various ions, owing distinct binding capacities. Combined recognition algorithm linear discriminant (LDA) hierarchical cluster (HCA), assay could realize single-component multicomponent qualitative 8 heavy ions (HMIs) including Cu

Language: Английский

Citations

2
A Gold Nanocage Probe Targeting Survivin for the Diagnosis of Pancreatic Cancer DOI Creative Commons
Lina Song, Shuai Ren, Yali Yue

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(5), P. 1547 - 1547

Published: May 19, 2023

In this paper, Au nanocages (AuNCs) loaded with the MRI contrast agent gadolinium (Gd) and capped tumor-targeting gene survivin (Sur–AuNC•Gd–Cy7 nanoprobes) were designed applied as a targeted imaging for pancreatic cancer. With its capacity to transport fluorescent dyes MR agents, gold cage is an outstanding platform. Furthermore, it has potential different drugs in future, making unique carrier The utilization of Sur–AuNC•Gd–Cy7 nanoprobes proven be effective means targeting localizing survivin-positive BxPC-3 cells within their cytoplasm. By survivin, antiapoptotic gene, nanoprobe was able induce pro-apoptotic effects cancer cells. biocompatibility AuNCs•Gd, AuNCs•Gd–Cy7 nanoparticles, evaluated through hemolysis rate assay. stability by determining hydrodynamic dimensions following storage pH solutions corresponding duration. Excellent will facilitate further vivo vitro. surface-bound plays role facilitating nanoprobes’ ability locate tumor. probe modified incorporate Gd Cy7, thereby enabling simultaneous magnetic resonance (MRI) fluorescence (FI) techniques. vivo, found effectively target localize tumors use FI. After being injected via caudal vein, accumulate situ model 24 h. these observed eliminated from body kidneys 72 h after single injection. This characteristic crucial diagnostic agent. Based on aforementioned outcomes, have significant advantages theranostic treatment possesses distinctive characteristics, such advanced abilities specific drug delivery, which offer possibility enhancing precision diagnosis efficacy destructive illness.

Language: Английский

Citations

4
Pb2+ Ion Sensors Employing Gold Etching Process: Comparative Investigation on Au Nanorods and Au Nanotriangles DOI Creative Commons
Eun Jin Park, Tai Hwan Ha

Sensors, Journal Year: 2024, Volume and Issue: 24(2), P. 497 - 497

Published: Jan. 13, 2024

The leaching phenomenon of gold (Au) nanomaterials by Pb2+ ions in the presence 2-mercaptoethanol (2-ME) and thiosulfate (S2O32− ion) has been systematically applied to a ion sensor. To further investigate role sensors containing Au nanomaterials, we revisited conditions for nanorods compared them with results nanotriangles. By monitoring etching rate, it was revealed that were important acceleration rate mainly driven 2-ME S2O32− pairs, nanomolar detection shown be promoted through this catalytic effect. Using etchant, overall size decreased but showed an unusual red-shift UV-Vis spectrum indicating increase aspect ratio. Indeed, length 9.4% width decreasing 17.4% over 30-min reaction time. On other hand, nanotriangles both flat sides surrounded mostly dense Au{111} planes ordinary blue-shift as one side reduced 21.3%. observing changes two types inferred there facet-dependent alloy formation lead, difference resulted showing good sensitivity, lower limits nanorods.

Language: Английский

Citations

0
Exosome, a Rising Biomarkers in Liquid Biopsy: Advances of Label-Free and Label Strategy for Diagnosis of Cancer DOI
Qian Liu,

Jing Zheng,

An Xie

et al.

Critical Reviews in Analytical Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 12

Published: April 26, 2024

Cancer is commonly considered as one of the most severe diseases, posing a significant threat to human health and society due various serious challenges. These challenges include difficulties in accurate diagnosis high propensity form metastasis. Tissue biopsy remains gold standard for diagnosing subtyping cancer. However, concerns arise from its invasive nature potential risk metastasis during these complex diagnostic procedures. Meanwhile, liquid has recently witnessed rapid advancements with emergence three prominent detection biomarkers: circulating tumor cells (CTCs), DNA (ctDNA), exosomes. Whereas, very low abundance CTCs combined instability ctDNA intensify decrease accuracy two biomarkers cancer diagnosis. While exosomes have gained widespread recognition promising biomarker their relatively low-invasive method, excellent biostability, rich resources, abundance, ability provide valuable information about Therefore, it crucial systematically summarize recent mainly exosome-based methods early Specifically, this review will primarily focus on label-based label-free strategies detecting using We anticipate that comprehensive analysis enhance readers' understanding significance value fields therapy.

Language: Английский

Citations

0
Papain-capped gold nanoflowers: dual functionality as peroxidase mimic and 4-nitrophenol reduction catalysts DOI Creative Commons
Dan Yan, Juan Liu, Yuanyuan Chen

et al.

Published: Oct. 8, 2024

A bifunctional ensemble of papain-capped gold nanoparticles (AuNFs) exhibits dual functionality, manifesting peroxidaselike and 4-nitrophenol reduction activities. The AuNFs, possessing an average size approximately 82.27 ± 1.95 nm, are synthesized under ambient conditions through the mediation papain, wherein HAuCl4 by ascorbic acid is facilitated. These nanoflowers capable catalyzing H2O2 to oxidize target 3,3,5,5-tetramethylbenzidine, resulting in production a visual color blue. Therefore, simple method providing sensitivity 0.44 µM (signal/noise ratio = 2) linearity within range 0 40 available detect colorimetry. Subsequently, chemical activity associated with 4-NP (4-nitrophenol) was studied, it found exhibit catalysis rate 0.29 min-1 , surpassing that alternative catalysts. findings underscore potential utility our AuNFs catalytic biosensing applications.

Language: Английский

Citations

0