Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 524, P. 216330 - 216330
Published: Nov. 14, 2024
Language: Английский
Journal of Global Antimicrobial Resistance, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
This study aims to investigate the effectiveness of UIO-66-NH2, a metal-organic framework (MOF), as carrier for imipenem/cilastatin (Imp/Cil) in overcoming resistance clinical isolates imipenem-resistant Pseudomonas aeruginosa. The UIO-66-NH2-Imp/Cil formulations were synthesized and characterized using dynamic light scattering (DLS), scanning electron microscopy (SEM) transmission (TEM). Drug entrapment efficiency UIO-66-NH2-Imp/Cil, Imp/Cil release rates determined. stability was assessed by at room temperature refrigeration two months. antibacterial, anti-biofilm anti-virulence activities investigated against aeruginosa isolates. formulation showed an average particle size 212.3 ± 7.3 nm, polydispersity index (PDI) 0.142 0.010, (EE%) 74.19 1.12%. from followed Korsmeyer-Peppas kinetic model, with 52% drug released over 72 hours. Antibacterial testing indicated significant decrease minimum inhibitory concentration (MIC) bactericidal (MBC) compared free Imp/Cil, demonstrating enhanced antibacterial activity. Furthermore, activity confirmed reduction bacterial hemolysis activity, minimal pyocyanin, EPS (extracellular polymeric substance) production, lower metabolic pathogens. Also, causes expression lasA, lasB and, rhlA genes, which resulted inhibition quorum-sensing (QS) system These findings indicate that nanocarriers offer promising new approach multidrug-resistant Gram-negative pathogens, providing insights into potential mechanisms antimicrobial action.
Language: Английский
Citations
1
Journal of Materials Chemistry A, Journal Year: 2023, Volume and Issue: 11(17), P. 9300 - 9332
Published: Jan. 1, 2023
This review provides a comprehensive overview of various advanced modification strategies metal-sulfide based nanomaterials for electrochemical CO 2 reduction to valuable products.
Language: Английский
Citations
20
Sensors and Actuators B Chemical, Journal Year: 2023, Volume and Issue: 393, P. 134146 - 134146
Published: June 15, 2023
Language: Английский
Citations
20
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown
Published: July 27, 2024
Abstract Regenerative biomedicine has emerged as a forefront area in medical research, heralding new era of therapeutic strategies. This review delineates the integration 2D materials (2DMs) within biomedical engineering, leveraging their superior physicochemical attributes for enhance outcomes. The synergistic interaction between biomacromolecules and 2DMs is explored, demonstrating potential to mitigate limitations inherent each while simultaneously augmenting beneficial properties. In particular, incorporating into hydrogels highlights capability mechanical strength hydrogels, providing biomimetic scaffold tissue engineering regeneration cancer diagnosis therapy. An overview synthetic methodologies are provided 2DMs, elucidating dynamics with biomacromolecules. primarily concentrates on applications biomacromolecule‐reinforced 2DM across various fields, including bone wound healing, neural cardiac well delivery drugs genes, therapy, biosensing technologies. Finally, discusses existing challenges future outlook developing using underlining transformative regenerative medicine.
Language: Английский
Citations
7
ACS Food Science & Technology, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 26, 2024
Language: Английский
Citations
7
Macromolecular Materials and Engineering, Journal Year: 2024, Volume and Issue: 309(6)
Published: April 18, 2024
Abstract The primary request nowadays is for innovative and superior scaffold designs that mimic the characteristics of native tissue in cartilage engineering. GelMA/Alginate (G/A) interpenetrating polymer network (IPN) has become a popular hydrogel material engineering because its mechanical biological properties. Here, to balance properties, composed G/A covalent organic frameworks (COF) nanoparticles specially designed. In this study, GelMA/Alginate/COF (G/A/C) with improved properties such as pore size, swelling, strength, shear‐thinning behavior, biocompatibility produced. Furthermore, G/A/C facilitate printing complex three dimensional (3D) scaffolds. test result demonstrates addition COF up 1% (w/w) enhances porosity decreases size (0.2 times), improves compression strength (six degradation ratio (0.05 times) swelling (0.3 compared sample. Besides, cell viability confirms growth during incubation great behavior (more than 98%). suitable performance containing shape fidelity injection by 3D printer confirmed. Nanocomposite IPN based on could be useful applications.
Language: Английский
Citations
6
Inorganic Chemistry Communications, Journal Year: 2023, Volume and Issue: 155, P. 111115 - 111115
Published: July 22, 2023
Language: Английский
Citations
14
ACS Biomaterials Science & Engineering, Journal Year: 2023, Volume and Issue: 9(10), P. 5724 - 5736
Published: Sept. 20, 2023
In recent years, multidrug therapy has gained increasing popularity due to the possibility of achieving synergistic drug action and sequential delivery different medical payloads for enhanced treatment efficacy. While a number composite material release platforms have been developed, few combine bottom-up design versatility metal-organic frameworks (MOFs) tailor behavior, with convenience temperature-responsive hydrogels (or thermogels) in their unique ease administration formulation. Yet, despite potential, MOF-thermogel composites largely overlooked simultaneous delivery. Herein, we report first systematic study common MOFs (UiO-66, MIL-53(Al), MIL-100(Fe), MOF-808) pore sizes, geometries, hydrophobicities ability achieve dual when embedded within PEG-containing thermogel matrices. After establishing that exert small influences on rheological properties thermogels penetration polymers into MOF pores solution, profiles ibuprofen caffeine as model hydrophobic hydrophilic drugs, respectively, from were investigated. Through these studies, elucidated important role matching between loaded drugs order component distinctly influence kinetics. These findings enabled us identify viable containing UiO-66 showed vastly kinetics caffeine, enabling temporally differentiated yet sustained be achieved. Finally, shown noncytotoxic vitro, paving way underexploited materials find possible clinical applications therapy.
Language: Английский
Citations
14
Regenerative Biomaterials, Journal Year: 2023, Volume and Issue: 11
Published: Dec. 23, 2023
Abstract Metal–organic frameworks (MOFs) have a high specific surface area, adjustable pores and can be used to obtain functional porous materials with diverse well-ordered structures through coordination self-assembly, which has intrigued wide interest in broad range of disciplines. In the arena biomedical engineering, functionalized modification MOFs produced drug carriers excellent dispersion functionalities such as target delivery response release, promising applications bio-detection, disease therapy, tissue healing, other areas. This review summarizes present state research on functionalization by physical binding or chemical cross-linking small molecules, polymers, biomacromolecules, hydrogels evaluates role approach boosting reactivity materials. On this basis, application composites engineering fields delivery, repair, treatment, bio-detection imaging is surveyed, development trend prospects an important new class field are anticipated, may provide some inspiration reference for further MOF bio-medical applications.
Language: Английский
Citations
14
Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 11
Published: Jan. 1, 2024
Abstract With the rapid development of materials science and tissue engineering, a variety biomaterials have been used to construct engineering scaffolds. Due performance limitations single materials, functional composite attracted great attention as tools improve effectiveness biological scaffolds for repair. In recent years, metal-organic frameworks (MOFs) shown promise application in because their high specific surface area, porosity, biocompatibility, appropriate environmental sensitivities other advantages. This review introduces methods construction MOFs-based describes functions mechanisms MOFs repairing damaged tissue. The latest composites applications different tissues are discussed. Finally, challenges future prospects using summarized. aim this is show potential field stimulate further innovation promising area.
Language: Английский
Citations
5