Recent advances and prospects of nanoparticle-based drug delivery for diabetic ocular complications DOI Creative Commons
Siqi Wang, Hongyu Yang, Jiaying Zheng

et al.

Theranostics, Journal Year: 2025, Volume and Issue: 15(8), P. 3551 - 3570

Published: Feb. 25, 2025

Diabetes mellitus (DM) is a chronic metabolic disorder that significantly affects various organ systems. The systemic effects of DM lead to numerous complications, with ocular manifestations being particular concern due their severity and impact on quality life. Hyperglycemia-induced damage often results in range lesions, including diabetic retinopathy (DR), keratopathy, cataracts, glaucoma. These conditions impose considerable physical discomfort patients place substantial economic burden healthcare advent nanotechnology has facilitated the development innovative therapeutic strategies for managing complications. This review highlights several common complications associated DM, focusing pathogenesis treatment strategies. Emphasis placed applications potential treating

Language: Английский

Novel nano-drug delivery system for natural products and their application DOI Creative Commons
Li Huang, Xuehua Huang, Xi Yang

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 201, P. 107100 - 107100

Published: Feb. 8, 2024

The development of natural products for potential new drugs faces obstacles such as unknown mechanisms, poor solubility, and limited bioavailability, which limit the broadened applicability products. Therefore, there is a need advanced pharmaceutical formulations active compounds or In recent years, novel nano-drug delivery systems (NDDS) products, including nanosuspensions, nanoliposomes, micelle, microemulsions/self-microemulsions, nanocapsules, solid lipid nanoparticles, have been developed to improve tissue distribution well prolonged retention enhanced permeation. Here, we updated NDDS used with enhancement in therapeutic efficiency observed nano-delivery systems.

Language: Английский

Citations

50
Advanced application of nanotechnology in active constituents of Traditional Chinese Medicines DOI Creative Commons
Chong Qiu,

Jun Zhe Zhang,

Bo Wu

et al.

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Nov. 29, 2023

Abstract Traditional Chinese Medicines (TCMs) have been used for centuries the treatment and management of various diseases. However, their effective delivery to targeted sites may be a major challenge due poor water solubility, low bioavailability, potential toxicity. Nanocarriers, such as liposomes, polymeric nanoparticles, inorganic nanoparticles organic/inorganic nanohybrids based on active constituents from TCMs extensively studied promising strategy improve achieve higher therapeutic effect with fewer side effects compared conventional formulations. This review summarizes recent advances in nanocarrier-based systems types TCMs, including terpenoids, polyphenols, alkaloids, flavonoids, quinones, different natural sources. covers design preparation nanocarriers, characterization, vitro/vivo evaluations. Additionally, this highlights challenges opportunities field suggests future directions research. Nanocarrier-based shown great improving efficacy serve comprehensive resource researchers field. Graphical abstract

Language: Английский

Citations

28
Targeting ferroptosis unveils a new era for traditional Chinese medicine: a scientific metrology study DOI Creative Commons
Siyang Cao, Yihao Wei, Yaohang Yue

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 14, 2024

In the past 11 years, there has been a surge in studies exploring regulatory effect of Traditional Chinese Medicine (TCM) on ferroptosis. However, significant gap persists comprehensive scientometric analysis and scientific mapping research, especially tracking evolution, primary contributors, emerging research focal points. This study aims to comprehensively update advancements targeting ferroptosis with various TCMs during previous years. The data, covering period from 1 January 2012, 30 November 2023, were retrieved Web Science database. For in-depth visualized analyses, series advanced analytical instruments employed. findings highlight China’s predominant role, accounting for 71.99% total publications significantly shaping this domain. Noteworthy productivity was observed at institutions, including Guangzhou University Medicine, Chengdu Zhejiang University. Thomas Efferth emerged as foremost author within field, while Frontiers Pharmacology boasted highest publication count. pinpointed hepatocellular carcinoma, chemical drug-induced liver injury, mitochondrial diseases, acute kidney failure most critical disorders addressed realm. offers bibliometric evaluation, enhancing our understanding present status TCM therapy managing ferroptosis-related diseases. Consequently, it aids both seasoned researchers newcomers by accelerating access vital information fostering innovative concept extraction specialized field.

Language: Английский

Citations

10
Collision of herbal medicine and nanotechnology: a bibliometric analysis of herbal nanoparticles from 2004 to 2023 DOI Creative Commons

Sinan Ai,

Yake Li,

Hui Juan Zheng

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: April 1, 2024

Abstract Background Herbal nanoparticles are made from natural herbs/medicinal plants, their extracts, or a combination with other nanoparticle carriers. Compared to traditional herbs, herbal lead improved bioavailability, enhanced stability, and reduced toxicity. Previous research indicates that medicine nanomaterials rapidly advancing making significant progress; however, bibliometric analysis knowledge mapping for currently lacking. We performed by retrieving publications related the Web of Science Core Collection (WoSCC) database spanning 2004 2023. Data processing was using R package Bibliometrix, VOSviewers, CiteSpace. Results In total, 1876 articles were identified, originating various countries, China being primary contributing country. The number in this field increases annually. Beijing University Chinese Medicine, Shanghai Traditional Saveetha India prominent institutions domain. Journal “International Nanomedicine” has highest publications. authors these reached 8234, Yan Zhao, Yue Zhang, Huihua Qu most prolific Zhao frequently cited author. “Traditional medicine,” “drug delivery,” “green synthesis” main focal points. Themes such as synthesis,” “curcumin,” “wound healing,” “carbon dots” may represent emerging areas. Conclusions Our study findings assist identifying latest frontiers hot topics, providing valuable references scholars investigating role nanotechnology medicine. Graphical

Language: Английский

Citations

10
Mogroside V reduced the excessive endoplasmic reticulum stress and mitigated the Ulcerative colitis induced by dextran sulfate sodium in mice DOI Creative Commons

Yue-Rong Tan,

Si-Yang Shen,

Xinyi Li

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: May 21, 2024

Abstract Ulcerative colitis (UC) is an idiopathic, chronic inflammatory condition of the colon, characterized by repeated attacks, a lack effective treatment options, and significant physical mental health complications for patients. The endoplasmic reticulum (ER) vital intracellular organelle in maintaining cellular homeostasis. Endoplasmic stress (ERS) induced when body exposed to adverse external stimuli. Numerous studies have shown that ERS-induced apoptosis plays role pathogenesis UC. Mogroside V (MV), active ingredient Monk fruit, has demonstrated excellent anti-inflammatory antioxidant effects. In this study, we investigated therapeutic effects MV on dextran sulfate sodium (DSS)-induced UC its potential mechanisms based ERS. results showed exerted protective effect against DSS-induced mice as reflected reduced DAI scores, increased colon length, histological scores levels pro-inflammatory cytokines, well decreased intestinal permeability. addition, expression ERS pathway including BIP, PERK, eIF2α, ATF4, CHOP, apoptosis-related protein Caspase-12, Bcl-2 Bax, was found be elevated However, significantly inhibited reversed inflammation signaling apoptosis. Additionally, addition tunicamycin (Tm), activator, weakened mice. These findings suggest may agent inhibiting activation ERS-apoptosis pathway, provide novel avenue

Language: Английский

Citations

9
Functionalized biomimetic nanoparticles loaded with salvianolic acid B for synergistic targeted triple-negative breast cancer treatment DOI Creative Commons
Nuo Cheng, Qianqian Zhou,

Zongfang Jia

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 30, P. 101441 - 101441

Published: Jan. 1, 2025

The therapeutic effect of immune checkpoint inhibitors (ICIs) in triple-negative breast cancer (TNBC) is unsatisfactory. "cold" microenvironment caused by tumor-associated fibroblasts (TAFs) has an adverse on the antitumor response. Therefore, this study, mixed cell membrane-coated porous magnetic nanoparticles (PMNPs) were constructed to deliver salvianolic acid B (SAB) induce response, facilitating transition from a "hot" tumor and ultimately enhancing efficacy inhibitors. PMNP-SAB, which based coating red blood membrane TAF (named PMNP-SAB@RTM), can simultaneously achieve dual effects "immune escape" "homologous targeting". Under influence external field (MF), SAB be targeted concentrated at site. released tumors effectively inhibit production extracellular matrix (ECM) TAFs, promote T-cell infiltration, responses. Ultimately, combination PMNP-SAB@RTM BMS-1 (PD-1/PD-L1 inhibitor 1) inhibited growth. Finally, study presents precise effective new strategy for TNBC immunotherapy basis differentiation microenvironments.

Language: Английский

Citations

1
Formation of a traditional Chinese medicine self-assembly nanostrategy and its application in cancer: a promising treatment DOI Creative Commons
Ju Huang,

Yu Zhu,

Hang Xiao

et al.

Chinese Medicine, Journal Year: 2023, Volume and Issue: 18(1)

Published: June 6, 2023

Traditional Chinese medicine (TCM) has been used for centuries to prevent and treat a variety of illnesses, its popularity is increasing worldwide. However, the clinical applications natural active components in TCM are hindered by poor solubility low bioavailability these compounds. To address issues, self-assembly nanostrategy (CSAN) being developed. Many possess properties, allowing them form nanoparticles (NPs) through various noncovalent forces. Self-assembled NPs (SANs) also present decoctions, they closely linked therapeutic effects remedies. SAN gaining nano research field due simplicity, eco-friendliness, enhanced biodegradability biocompatibility compared traditional preparation methods. The ingredients from that exhibit antitumour or combined with other drugs generated considerable interest cancer therapeutics. This paper provides review principles forms CSAN, as well an overview recent reports on can be self-assembly. Additionally, application CSAN diseases summarized, finally, concluding summary thoughts proposed. We strongly believe potential offer fresh strategies perspectives modernization TCM.

Language: Английский

Citations

19
Exploiting Nanotechnology for Drug Delivery: Advancing the Anti-Cancer Effects of Autophagy-Modulating Compounds in Traditional Chinese Medicine DOI Creative Commons
Zixian Liu, Tianming Lu,

Ruoning Qian

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 2507 - 2528

Published: March 1, 2024

Background: Cancer continues to be a prominent issue in the field of medicine, as demonstrated by recent studies emphasizing significant role autophagy development cancer. Traditional Chinese Medicine (TCM) provides variety anti-tumor agents capable regulating autophagy. However, clinical application autophagy-modulating compounds derived from TCM is impeded their restricted water solubility and bioavailability. To overcome this challenge, utilization nanotechnology has been suggested potential solution. Nonetheless, current body literature on nanoparticles delivering TCM-derived for cancer treatment limited, lacking comprehensive summaries detailed descriptions. Methods: Up November 2023, research study was conducted gather relevant data using databases, including PubMed, ScienceDirect, Springer Link, Web Science, CNKI. The keywords utilized investigation included "autophagy", "nanoparticles", "traditional medicine" "anticancer". Results: This review analysis overcoming delivery challenges enhancing anti-cancer properties TCM. evaluation based synthesis different classes TCM, mechanisms action treatment, benefits reported various scholarly sources. findings indicate that shows availability thereby opening up plethora therapeutic avenues. Conclusion: Nanotechnology enhance efficacy traditional through regulation Keywords: autophagy, nano-delivery, anti-cancer, medicine

Language: Английский

Citations

7
Nanoliposomes Encapsulated Rapamycin/Resveratrol to Induce Apoptosis and Ferroptosis for Enhanced Colorectal Cancer Therapy DOI
Menglei Jia,

Xiaoxiao Tan,

Zhongwen Yuan

et al.

Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 113(8), P. 2565 - 2574

Published: May 19, 2024

Language: Английский

Citations

7
Unlocking the Medicinal Potential of Plant-Derived Extracellular Vesicles: current Progress and Future Perspectives DOI Creative Commons
Xiaoliang Liu,

Kecheng Lou,

Y.‐H. Percival Zhang

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 4877 - 4892

Published: May 1, 2024

Abstract: Botanical preparations for herbal medicine have received more and attention from drug researchers, the extraction of active ingredients their successful clinical application become an important direction research in major pharmaceutical companies, but complexity extracts, multiple side effects, significant individual differences brought many difficulties to preparations. It is noteworthy that extracellular vesicles as biomolecules extracted medicinal plants are believed be useful treatment a variety diseases, including cancer, inflammation, regenerative-restorative degenerative which may provide new utilization In this review, we sort out recent advances plant discuss potential disease therapeutics. Finally, future challenges directions translation also discussed, expect continued development based on will facilitate Keywords: plant-derived vesicles, Chinese preparation, nanoparticle, delivery nanoplatforms, nanotherapeutics

Language: Английский

Citations

7