Deleted Journal,
Journal Year:
2023,
Volume and Issue:
27, P. 125 - 137
Published: Jan. 1, 2023
Preventing
the
spread
of
disease,
whether
by
viral
or
bacterial
pathogens,
involves
protectingbillions
people
and
subsequent
factors
in
process.
Vaccination
is
undoubtedly
mosteffective
way
to
achieve
this.
Many
countries
prioritize
vaccination
campaigns
for
publichealth
well-being
their
inhabitants.
Vaccine
development
has
been
based
on
4
main
types,whose
response
effective
many
diseases;
however,
some
them
have
shown
havelimitations
certain
clinical
conditions.
Therefore,
identification
new
candidates
forvaccine
attracted
attention
research
groups.
According
thehumoral
cellular
immune
induced
a
vaccine,
its
effectiveness
against
diseaseis
measured.
Microvesicles
(MVs)
are
nanometer-sized
vesicles
that
secreted
into
extracellularspace,
whose
contents
consist
carbohydrates,
proteins,
lipids,
nucleic
acids
(DNAand
RNA)
other
metabolites.
This
conformation
can
be
used
as
vehicle
transport
antigensand
immunogenic
molecules
directly
target
cells.
A
vaccine
multidrug-resistantbacterium
Neisseria
gonorrhoeae
already
developed
using
outer
membrane
vesicles(OMVs),
was
promising.
In
this
review,
we
will
study
participation
ofmicrovesicles
Gram-positive
Gram-negative
bacteria
different
isolates,
thepathogenicity
processes
which
they
participate,
usefulness
immunogenicmolecules
components
multidrug-resistantbacteria.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(10), P. 8542 - 8542
Published: May 10, 2023
Outer
membrane
vesicles
(OMVs)
are
lipid-membrane-bounded
nanoparticles
that
released
from
Gram-negative
bacteria
via
vesiculation
of
the
outer
membrane.
They
have
vital
roles
in
different
biological
processes
and
recently,
they
received
increasing
attention
as
possible
candidates
for
a
broad
variety
biomedical
applications.
In
particular,
OMVs
several
characteristics
enable
them
to
be
promising
immune
modulation
against
pathogens,
such
their
ability
induce
host
responses
given
resemblance
parental
bacterial
cell.
Helicobacter
pylori
(H.
pylori)
is
common
bacterium
infects
half
world's
population
causes
gastrointestinal
diseases
peptic
ulcer,
gastritis,
gastric
lymphoma,
carcinoma.
The
current
H.
treatment/prevention
regimens
poorly
effective
limited
success.
This
review
explores
status
future
prospects
biomedicine
with
special
focus
on
use
potential
candidate
its
associated
diseases.
emerging
strategies
can
used
design
viable
immunogenic
discussed.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(4), P. 1052 - 1052
Published: March 24, 2023
Bacterial
membrane
vesicles
(BMVs)
are
known
to
be
critical
communication
tools
in
several
pathophysiological
processes
between
bacteria
and
host
cells.
Given
this
situation,
BMVs
for
transporting
delivering
exogenous
therapeutic
cargoes
have
been
inspiring
as
promising
platforms
developing
smart
drug
delivery
systems
(SDDSs).
In
the
first
section
of
review
paper,
starting
with
an
introduction
pharmaceutical
technology
nanotechnology,
we
delve
into
design
classification
SDDSs.
We
discuss
characteristics
including
their
size,
shape,
charge,
effective
production
purification
techniques,
different
methods
used
cargo
loading
encapsulation.
also
shed
light
on
release
mechanism,
carriers,
recent
remarkable
findings
potential
anticancer
antimicrobial
therapy.
Furthermore,
covers
safety
challenges
that
need
overcome
clinical
use.
Finally,
advancements
prospects
SDDSs
highlight
revolutionizing
fields
nanomedicine
delivery.
conclusion,
paper
aims
provide
a
comprehensive
overview
state-of-the-art
field
SDDSs,
encompassing
design,
composition,
fabrication,
purification,
characterization,
well
various
strategies
targeted
Considering
information,
aim
is
researchers
understanding
current
state
enabling
them
identify
gaps
formulate
new
hypotheses
accelerate
progress
field.
Pharmedicine journal.,
Journal Year:
2025,
Volume and Issue:
2(1), P. 1 - 7
Published: Feb. 28, 2025
The
misuse
and
overuse
of
antibiotics
have
driven
the
emergence
antibiotic-resistant
bacteria
in
recent
decades.
With
increasing
incidence
resistant
strains
significant
slowdown
new
antibiotic
discoveries,
treating
bacterial
infections
has
become
more
challenging.
Therefore,
there
is
an
urgent
need
to
explore
alternative
treatments,
such
as
using
outer
membrane
vesicles
(OMVs)
for
targeted
delivery.
OMVs
are
nanoscale,
spherical
structures
originating
from
Gram-negative
bacteria's
membrane.
These
naturally
released
by
almost
all
types
into
their
environment
during
growth
play
crucial
roles
pathogenesis
transporting
specific
biomolecules,
toxins
other
virulence
factors,
host
cells.
Due
unique
ability
encapsulate
transport
various
bioactive
molecules
across
Gram
negative
cell
membrane,
nanosized
hold
potential
a
novel
platform
This
review
discusses
biogenesis,
biofunctions,
antibacterial
applications
OMVs.
Membranes,
Journal Year:
2025,
Volume and Issue:
15(5), P. 141 - 141
Published: May 5, 2025
Outer
membrane
vesicles
(OMVs)
are
extracellular
secreted
by
Gram-negative
bacteria
with
diameters
of
20–250
nm.
OMVs
contain
various
biologically
active
substances
from
their
parent
bacteria,
such
as
proteins,
lipids,
and
nucleic
acids.
Escherichia
coli
Nissle
1917
(EcN)
is
a
probiotic
that
resides
in
the
human
intestine.
EcN-derived
pivotal
modulating
intestinal
immune
responses.
However,
few
studies
have
addressed
heterogeneity
terms
size,
significantly
limiting
research
on
clinical
applications.
Currently,
there
lack
feasible
methods
for
obtaining
different
sizes.
To
address
this
knowledge
gap,
we
developed
filtration
method
to
isolate
varying
In
study,
first
used
gradient
high-purity
conducted
proteomic
analysis.
Subsequently,
separate
size.
We
successfully
obtained
three
specific
sizes:
<50
nm,
50–100
100–300
then
performed
analyses
these
compared
protein
profiles.
Finally,
ability
each
OMV
type
induce
RAW264.7
macrophages
secrete
pro-inflammatory
factor
interleukin
(IL)-1β
anti-inflammatory
IL-10.
The
contained
646
proteins
overall;
those
sizes
types.
Among
them,
nm
group
fewer
(262
types
total)
than
(1603
types)
(1568
groups.
Furthermore,
had
(40)
(215)
(209)
also
found
concentrations
IL-1β
IL-10
following
co-incubation
showed
stronger
effect
inducing
inflammatory
cytokine
secretion
other
two
This
study
provides
direct
experimental
evidence
exhibit
heterogeneous
properties.
Extracellular Vesicles and Circulating Nucleic Acids,
Journal Year:
2023,
Volume and Issue:
4(2), P. 255 - 61
Published: Jan. 1, 2023
Gram-negative
bacteria
naturally
shed
lipid
vesicles,
which
contain
complex
molecular
cargoes,
from
their
outer
membrane.
These
membrane
vesicles
(OMVs)
have
important
biological
functions
relating
to
microbial
stress
responses,
microbiome
regulation,
and
host-pathogen
interactions.
OMVs
are
also
attractive
vehicles
for
delivering
drugs,
vaccines,
other
therapeutic
agents
because
of
ability
interact
with
host
cells
natural
immunogenic
properties.
set
a
positive
impact
on
biotechnological
medical
applications
including
diagnostics,
bioremediation,
metabolic
engineering.
We
envision
that
the
field
synthetic
biology
offers
compelling
opportunity
further
expand
accelerate
foundational
research
downstream
in
range
provision
OMV-based
healthcare
technologies.
In
our
opinion,
we
discuss
how
current
potential
future
synergies
between
OMV
approaches
might
help
real-world
benefit
animal
human
health.
Frontiers in Chemistry,
Journal Year:
2023,
Volume and Issue:
11
Published: Oct. 17, 2023
Photodynamic
Therapy
(PDT)
is
an
effective
tumor
treatment
strategy
that
not
only
induces
photocytotoxicity
to
kill
cells
directly
but
also
activates
the
immune
system
in
body
generate
tumor-specific
immunity,
preventing
cancer
metastasis
and
recurrence.
However,
some
limitations
of
PDT
limit
therapeutic
efficacy
deep
tumors.
Previous
studies
have
used
different
types
nanoparticles
(NPs)
as
drug
carriers
photosensitizers
(PSs)
overcome
shortcomings
improve
efficacy.
Among
them,
bacterial
outer
membrane
vesicles
(OMVs)
natural
advantages
for
PS
delivery.
In
addition
targeted
delivery
PSs
into
cells,
their
unique
immunogenicity
helps
them
serve
adjuvants
enhance
PDT-induced
effect,
providing
new
ideas
photodynamic
anticancer
therapy.
Therefore,
this
review,
we
will
introduce
biogenesis
functions
OMVs
research
on
PDT.
Finally,
discuss
challenges
prospects
a
versatile
carrier
